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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.520
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.518
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.515
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.515
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.514
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.513
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.507
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.505
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.501
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.501
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.499
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.498
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.498
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.498
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.497
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.496
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.493
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.492
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.491
2hog710Serine/threonine-protein kinase Chk12.7.11.10.490
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.490
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.489
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.489
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.487
1zys199Serine/threonine-protein kinase Chk12.7.11.10.486
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.486
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.485
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.485
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.484
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.483
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.483
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.482
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.482
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.481
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.481
2wipP49Cyclin-dependent kinase 22.7.11.220.481
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.481
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.481
3zh8C58Protein kinase C iota type2.7.11.130.480
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.480
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.479
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.478
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.478
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.477
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.476
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.475
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.475
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.473
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.472
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.471
1aq1STUCyclin-dependent kinase 22.7.11.220.470
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.470
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.470
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.470
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.470
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.470
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.470
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.469
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.469
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.469
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.469
3gubGUBDeath-associated protein kinase 12.7.11.10.468
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.468
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.468
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.467
2i40BLZCyclin-dependent kinase 22.7.11.220.466
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.466
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.466
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.466
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.466
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.466
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.465
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.464
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.464
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.464
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.464
3r9dX6BCyclin-dependent kinase 22.7.11.220.463
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.463
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.462
3a62STURibosomal protein S6 kinase beta-12.7.11.10.462
1xjdSTUProtein kinase C theta type2.7.11.130.461
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.461
2wtjWTJSerine/threonine-protein kinase Chk22.7.11.10.461
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.461
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.461
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.460
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.460
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.459
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.459
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.459
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.457
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.457
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.456
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.456
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.455
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.455
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.454
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.454
3sheI85MAP kinase-activated protein kinase 32.7.11.10.454
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.453
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.452
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.451
4fto3HKSerine/threonine-protein kinase Chk12.7.11.10.451
4hvh19RTyrosine-protein kinase JAK32.7.10.20.451
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.450
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.450
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.449
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.449
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
1wvxBD4Death-associated protein kinase 12.7.11.10.448
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.448
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.447
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.447
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.447
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.447
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.447
4cztCPSCBL-interacting serine/threonine-protein kinase 232.7.11.10.447
2b7aIZATyrosine-protein kinase JAK2/0.446
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.446
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.445
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3ztxZTXAurora kinase B-A2.7.11.10.444
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.444
4nk92K5Fibroblast growth factor receptor 1/0.444
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.443
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.443
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.443
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.443
2bkzSBCCyclin-dependent kinase 22.7.11.220.442
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.442
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.442
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.441
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
1pkdUCNCyclin-dependent kinase 22.7.11.220.440
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.440
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.440
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.440
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.440
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.440
4brxKGWFocal adhesion kinase 12.7.10.20.440
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.440
4qnaX11Serine/threonine-protein kinase 242.7.11.10.440