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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.610
1xh9R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.599
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.597
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.580
1xh8R55cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.573
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.565
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.562
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.552
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.551
1xh4R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.550
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.548
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.536
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.529
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.529
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.528
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.528
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.519
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.515
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.512
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.505
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.503
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.501
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.494
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.493
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.471
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.463
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.458
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
3v5w8PRBeta-adrenergic receptor kinase 12.7.11.150.451
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
4qnyANPMitogen activated protein kinase, putative/0.450
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
1jklANPDeath-associated protein kinase 12.7.11.10.442
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.441
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3x2wATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.441
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
4ysjADPCalmodulin-like domain protein kinase/0.440