sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1rbz | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1rbz | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 1.000 | |
| 1rbm | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.624 | |
| 1njs | KEU | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.612 | |
| 1rbq | KEU | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.608 | |
| 1rc0 | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.602 | |
| 1c3e | NHR | Phosphoribosylglycinamide formyltransferase | / | 0.561 | |
| 1c2t | NHS | Phosphoribosylglycinamide formyltransferase | / | 0.551 | |
| 1jkx | 138 | Phosphoribosylglycinamide formyltransferase | / | 0.503 | |
| 1rby | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.496 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.491 | |
| 5hsa | FAS | Alcohol oxidase 1 | 1.1.3.13 | 0.491 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.489 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.489 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.488 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.487 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.487 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.486 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.486 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.486 | |
| 1c2t | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.483 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.482 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 5c77 | SAH | Protein arginine N-methyltransferase SFM1 | / | 0.479 | |
| 3e5r | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic | 1.2.1.12 | 0.478 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.475 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.475 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.475 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.475 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.474 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.473 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.473 | |
| 1uum | AFI | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.472 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.471 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.471 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.470 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.470 | |
| 2oor | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.470 | |
| 3cif | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.470 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.470 | |
| 4h3q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.470 | |
| 4jay | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.470 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.469 | |
| 3vob | 9PC | Cell division protein FtsZ | / | 0.469 | |
| 4nak | PBQ | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic | 2.7.7.60 | 0.469 | |
| 1cde | DZF | Phosphoribosylglycinamide formyltransferase | / | 0.468 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.468 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.468 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.467 | |
| 3gc8 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.467 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.467 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.466 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.466 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.466 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.466 | |
| 4ew2 | DXY | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.466 | |
| 4ew3 | DXZ | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.466 | |
| 4o59 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.466 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3syi | FAD | Sulfide-quinone reductase | / | 0.465 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.465 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.465 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.465 | |
| 1opm | IYG | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.464 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.464 | |
| 3pcr | GTP | ADP-ribosylation factor 6 | / | 0.464 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.464 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.464 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.464 | |
| 1c3e | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.463 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.463 | |
| 3g7j | GTX | Glutathione transferase GST1-4 | / | 0.463 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.463 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.463 | |
| 4i2q | 1BT | Gag-Pol polyprotein | 2.7.7.49 | 0.463 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.463 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.463 | |
| 1ori | SAH | Protein arginine N-methyltransferase 1 | / | 0.462 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.462 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.462 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.462 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.462 | |
| 1dss | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.461 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.461 | |
| 2uzt | SS3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.461 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.461 | |
| 4l4x | NDP | AmphI | / | 0.461 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.460 | |
| 1vdc | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.460 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.460 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.460 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.460 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.460 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.460 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.460 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.460 | |
| 4jwh | SAH | tRNA (guanine(9)-N1)-methyltransferase | / | 0.460 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.460 | |
| 1sbg | IM1 | Gag-Pol polyprotein | / | 0.459 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.459 | |
| 2vyn | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.459 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.459 | |
| 3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 0.459 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.459 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.459 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.459 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.458 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.458 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 3zdi | UGJ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.458 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.458 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.458 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.458 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.458 | |
| 2zfn | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.457 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.457 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.457 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.457 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.457 | |
| 4hfm | NAP | 2-alkenal reductase (NADP(+)-dependent) | / | 0.457 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.457 | |
| 5a3b | APR | SIR2 family protein | / | 0.457 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.456 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1hnc | GDN | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.456 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.456 | |
| 1ndi | COA | Carnitine O-acetyltransferase | 2.3.1.7 | 0.456 | |
| 2gu8 | 796 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.456 | |
| 2hfp | NSI | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.456 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.456 | |
| 3e8n | VRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.456 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4dsg | FAD | Uncharacterized protein | / | 0.456 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.455 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1xkk | FMM | Epidermal growth factor receptor | 2.7.10.1 | 0.455 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.455 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.455 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.455 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.455 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.455 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.455 | |
| 3kgc | LY7 | Glutamate receptor 2 | / | 0.455 | |
| 3lzs | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3pvz | NAD | UDP-N-acetylglucosamine 4,6-dehydratase | / | 0.455 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3sfe | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.455 | |
| 4a4q | UX9 | Pol protein | / | 0.455 | |
| 4f9m | FCM | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 4zoh | FAD | Putative oxidoreductase FAD-binding subunit | / | 0.455 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.454 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.454 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.454 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.454 | |
| 3mwu | BK3 | Calmodulin-domain protein kinase 1, putative | / | 0.454 | |
| 3v5l | 0G1 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.454 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.454 | |
| 4o8a | FAD | Bifunctional protein PutA | 1.2.1.88 | 0.454 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.454 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 1mez | GDP | Adenylosuccinate synthetase isozyme 1 | / | 0.453 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.453 | |
| 1w2x | RCP | Acetyl-CoA carboxylase | / | 0.453 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.453 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.453 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.453 | |
| 3i4b | Z48 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.453 | |
| 3u4c | NDP | NADPH-dependent reductase BacG | / | 0.453 | |
| 3vs5 | VSG | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.453 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.453 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.453 | |
| 1ha3 | MAU | Elongation factor Tu-A | / | 0.452 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.452 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.452 | |
| 2q4w | FAD | Cytokinin dehydrogenase 7 | 1.5.99.12 | 0.452 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.452 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.452 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.452 | |
| 5dp2 | NAP | CurF | / | 0.452 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.451 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.451 | |
| 1vik | BAY | Gag-Pol polyprotein | / | 0.451 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.451 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.451 | |
| 2ylr | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.451 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.451 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.451 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.451 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.451 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.451 | |
| 4nif | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.451 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.451 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.451 | |
| 1a8p | FAD | Ferredoxin--NADP reductase | / | 0.450 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.450 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.450 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.450 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.450 | |
| 2gd2 | CAA | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.450 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.450 | |
| 2p2j | PRX | Acetyl-coenzyme A synthetase | / | 0.450 | |
| 3haz | FAD | Bifunctional protein PutA | / | 0.450 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.450 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.450 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.450 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.450 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.450 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.450 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.450 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.450 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.450 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 1f0x | FAD | D-lactate dehydrogenase | 1.1.1.28 | 0.449 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.449 | |
| 2ign | FAD | Pyranose 2-oxidase | / | 0.449 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.449 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 3ffi | 3OB | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.449 | |
| 3umo | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.449 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 4iah | 1DX | Alr2278 protein | / | 0.449 | |
| 4qec | NAP | ElxO | / | 0.449 | |
| 1cbo | FAD | Cholesterol oxidase | 1.1.3.6 | 0.448 | |
| 1f12 | 3HC | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.448 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.448 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.448 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.448 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.448 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.448 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 2wbd | RO5 | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 0.448 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.448 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 3eku | CY9 | Actin-5C | / | 0.448 | |
| 3pjt | C2E | Diguanylate cyclase/phosphodiesterase | / | 0.448 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.448 | |
| 3suf | SUE | Polyprotein | / | 0.448 | |
| 4a61 | ANP | Plasmid segregation protein ParM | / | 0.448 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 4jk3 | NAD | Uncharacterized protein | / | 0.448 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.448 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.448 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.448 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 2uzu | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.447 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.447 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.447 | |
| 4a4v | YFD | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.447 | |
| 4k2x | FAD | Polyketide oxygenase/hydroxylase | / | 0.447 | |
| 5eb5 | FAD | (R)-mandelonitrile lyase 1 | 4.1.2.10 | 0.447 | |
| 1gd1 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.446 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.446 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.446 | |
| 2gtk | 208 | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.446 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.446 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.446 | |
| 3ogq | AB1 | Pol polyprotein | / | 0.446 | |
| 3r5z | F42 | Uncharacterized protein | / | 0.446 | |
| 3toh | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4fk8 | FAD | Ferredoxin--NADP reductase | / | 0.446 | |
| 4fsq | HK3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 1cde | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.445 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.445 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1zmd | NAI | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.445 | |
| 2cdu | FAD | NADH oxidase | / | 0.445 | |
| 2fsv | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.445 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.445 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.445 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.445 | |
| 2y3r | TIR | TamL | / | 0.445 | |
| 2z54 | AB1 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.445 | |
| 2zu8 | GDD | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.445 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.445 | |
| 3fpz | AHZ | Thiamine thiazole synthase | / | 0.445 | |
| 3h0a | D30 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.445 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.445 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.445 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.445 | |
| 3tvu | B37 | Acetyl-CoA carboxylase | / | 0.445 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.445 | |
| 4bib | IEO | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.445 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.445 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.445 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 1cbr | REA | Cellular retinoic acid-binding protein 1 | / | 0.444 | |
| 1eio | GCH | Gastrotropin | / | 0.444 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.444 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.444 | |
| 2pob | GW4 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.444 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.444 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.444 | |
| 3q33 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.444 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.444 | |
| 3t11 | 3T1 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.444 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.444 | |
| 4dxd | 9PC | Cell division protein FtsZ | / | 0.444 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.443 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.443 | |
| 1hwz | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.443 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.443 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 1q0q | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.443 | |
| 1tj2 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.443 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.443 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.443 | |
| 1xl5 | 190 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.443 | |
| 2izs | BRQ | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.443 | |
| 2j3k | NAP | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.443 | |
| 2owk | SAH | Diphthine synthase | / | 0.443 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.443 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3f8r | NAP | NADH oxidase/thioredoxin reductase | / | 0.443 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.443 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.443 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.443 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 3vqu | O22 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.443 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.443 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.443 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.443 | |
| 4mq1 | 2C3 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.443 | |
| 4n1g | CEI | Obelin | / | 0.443 | |
| 4qi7 | FAD | Cellobiose dehydrogenase | / | 0.443 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.442 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.442 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.442 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.442 | |
| 1nlm | UD1 | UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | / | 0.442 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.442 | |
| 2ylx | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.442 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.442 | |
| 3da1 | FAD | Glycerol-3-phosphate dehydrogenase | / | 0.442 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.442 | |
| 3fcj | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.442 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.442 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.442 | |
| 3ndu | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3tz3 | B36 | Acetyl-CoA carboxylase | / | 0.442 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.442 | |
| 3vey | 0H5 | Glucokinase | 2.7.1.2 | 0.442 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.442 | |
| 4aic | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.442 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.442 | |
| 4h3y | SAH | tRNA (guanine-N(1)-)-methyltransferase | / | 0.442 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 4kip | 1R9 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 4zp0 | DXC | Multidrug transporter MdfA | / | 0.442 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1c1d | NAI | Phenylalanine dehydrogenase | / | 0.441 | |
| 1cc2 | FAD | Cholesterol oxidase | 1.1.3.6 | 0.441 | |
| 1gth | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.441 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.441 | |
| 2ic3 | HBY | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.441 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.441 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.441 | |
| 2xfy | ACX | Beta-amylase | 3.2.1.2 | 0.441 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.441 | |
| 2zgz | GNP | Plasmid segregation protein ParM | / | 0.441 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.441 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.441 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.441 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.441 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3spt | UD1 | Bifunctional protein GlmU | / | 0.441 | |
| 3u9e | COA | Lmo1369 protein | / | 0.441 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4eet | FMN | Phototropin-2 | 2.7.11.1 | 0.441 | |
| 4ft0 | HK9 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.441 | |
| 4qi4 | FAD | Cellobiose dehydrogenase | / | 0.441 | |
| 4udq | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.441 | |
| 4wri | OKA | Okadaic acid binding protein 2-alpha | / | 0.441 | |
| 4yfy | 1YJ | VioF | / | 0.441 | |
| 5ez7 | FAD | Probable FAD-dependent oxidoreductase PA4991 | / | 0.441 | |
| 1qf5 | RPL | Adenylosuccinate synthetase | / | 0.440 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1uxj | NAD | Malate dehydrogenase | / | 0.440 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.440 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2ooy | ATP | 5'-AMP-activated protein kinase subunit gamma | / | 0.440 | |
| 2p3b | 3TL | V-1 PROTEASE protein | / | 0.440 | |
| 2p3b | 3TL | V-1 protease | / | 0.440 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.440 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.440 | |
| 3iob | A4D | Pantothenate synthetase | 6.3.2.1 | 0.440 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 3sw1 | FMN | Sensory box protein | / | 0.440 | |
| 3tog | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3vvp | BNU | Uncharacterized protein | / | 0.440 | |
| 3zxs | FAD | Deoxyribodipyrimidine photolyase-related protein | / | 0.440 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4e73 | 0NR | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.440 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.440 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.440 | |
| 4fko | 20K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.440 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.440 | |
| 4pao | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.440 | |
| 5cno | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.440 |