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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1rbyGARTrifunctional purine biosynthetic protein adenosine-32.1.2.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1rbyGARTrifunctional purine biosynthetic protein adenosine-32.1.2.21.000
1c2tGARPhosphoribosylglycinamide formyltransferase/0.588
1c3eGARPhosphoribosylglycinamide formyltransferase/0.574
1menGARTrifunctional purine biosynthetic protein adenosine-32.1.2.20.569
1cdeGARPhosphoribosylglycinamide formyltransferase/0.555
1njsKEUTrifunctional purine biosynthetic protein adenosine-32.1.2.20.482
1jkx138Phosphoribosylglycinamide formyltransferase/0.477
1kzjCB3Thymidylate synthase/0.475
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.472
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.465
1rbqKEUTrifunctional purine biosynthetic protein adenosine-32.1.2.20.464
1rbzKT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.464
2g8yNADHydroxycarboxylate dehydrogenase B/0.460
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
2p5uNADUDP-glucose 4-epimerase/0.456
2xynVX6Abelson tyrosine-protein kinase 22.7.10.20.454
1y0s331Peroxisome proliferator-activated receptor delta/0.451
3oquA8SAbscisic acid receptor PYL9/0.451
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
2b7aIZATyrosine-protein kinase JAK2/0.450
2zjmF1MBeta-secretase 13.4.23.460.450
2vxoXMPGMP synthase [glutamine-hydrolyzing]6.3.5.20.449
3tvuB37Acetyl-CoA carboxylase/0.449
3umoATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.449
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1rc0KT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.447
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.445
1mewXMPInosine-5'-monophosphate dehydrogenase/0.444
4egbNADdTDP-glucose 4,6-dehydratase/0.442
2p33J07Mitogen-activated protein kinase 102.7.11.240.441
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.441
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
2vmyFFOSerine hydroxymethyltransferase/0.440
3cgcCOACoenzyme A disulfide reductase/0.440