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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1r6uTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1r6uTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.21.000
1r6tTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.601
3kt3TYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.550
3jxeTYMTryptophan--tRNA ligase/0.542
4j75TYMTryptophan--tRNA ligase/0.538
2qujTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.522
1vbmYSATyrosine--tRNA ligase6.1.1.10.481
3zxiTYATyrosine--tRNA ligase, mitochondrial6.1.1.10.467
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.458
4wsoNADProbable nicotinate-nucleotide adenylyltransferase/0.454
2iko7IGRenin3.4.23.150.450
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.448
1i6kTYMTryptophan--tRNA ligase6.1.1.20.442
2pidYSATyrosine--tRNA ligase, mitochondrial6.1.1.10.441