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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1r1jOIRNeprilysin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1r1jOIRNeprilysin/1.000
4zr5RDFNeprilysin/0.603
1r1iTI1Neprilysin/0.542
3zukRDFEndopeptidase, peptidase family M13/0.530
4cthRDFNeprilysin/0.491
3dwbRDFEndothelin-converting enzyme 13.4.24.710.488
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.462
2rd2QSIGlutamine--tRNA ligase6.1.1.180.442
4driRAPSerine/threonine-protein kinase mTOR2.7.11.10.442
4driRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.442