sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1qmf | KEF | Penicillin-binding protein 2x |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1qmf | KEF | Penicillin-binding protein 2x | / | 1.000 | |
| 3u9e | COA | Lmo1369 protein | / | 0.470 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.466 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.466 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.465 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.456 | |
| 4fr4 | STU | Serine/threonine-protein kinase 32A | 2.7.11.1 | 0.456 | |
| 4idv | 13V | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.454 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.454 | |
| 1ie4 | T44 | Transthyretin | / | 0.452 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.452 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.451 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.450 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.449 | |
| 2voj | NAD | Alanine dehydrogenase | 1.4.1.1 | 0.448 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 2daa | DCS | D-alanine aminotransferase | 2.6.1.21 | 0.447 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.447 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 3lpf | Z77 | Beta-glucuronidase | 3.2.1.31 | 0.447 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.447 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.446 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.445 | |
| 3crz | FAD | Ferredoxin--NADP+ reductase | / | 0.444 | |
| 3ddq | RRC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3w0p | ADP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.444 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.442 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.441 | |
| 2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3ogq | AB1 | Pol polyprotein | / | 0.441 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.441 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.440 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.440 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.440 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.440 |