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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1qd1FONFormimidoyltransferase-cyclodeaminase2.1.2.5

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1qd1FONFormimidoyltransferase-cyclodeaminase2.1.2.51.000
2xlrFADPutative flavin-containing monooxygenase/0.507
1obnASVIsopenicillin N synthase1.21.3.10.492
3gwdFADCyclohexanone monooxygenase/0.484
2iko7IGRenin3.4.23.150.481
1f8fNADBenzyl alcohol dehydrogenase/0.470
1xddAAYIntegrin alpha-L/0.470
3iaaTYDCalG2/0.470
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.470
4s1hADPPyridoxal kinase, putative/0.468
2qjoNADBifunctional NMN adenylyltransferase/Nudix hydrolase2.7.7.10.467
3zkyWT4Isopenicillin N synthase1.21.3.10.466
4b68NAPL-ornithine N(5)-monooxygenase/0.466
1h61PDNPentaerythritol tetranitrate reductase/0.465
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.464
3nxxNDPDihydrofolate reductase1.5.1.30.463
2vbpVB1Isopenicillin N synthase1.21.3.10.462
1pqc444Oxysterols receptor LXR-beta/0.461
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.460
1j1zATPArgininosuccinate synthase/0.459
4twnB96Ephrin type-A receptor 32.7.10.10.459
4ytnFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.459
1i2bNADUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.458
2iviACWIsopenicillin N synthase1.21.3.10.458
2vprTDCTetracycline repressor protein class H/0.457
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.457
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.456
3q9tFAYUncharacterized protein/0.456
5ch7MD1DMSO reductase family type II enzyme, molybdopterin subunit/0.456
1cf3FADGlucose oxidase1.1.3.40.455
1dgmADNAdenosine kinase2.7.1.200.455
2g226IGRenin3.4.23.150.455
2rgoFADAlpha-Glycerophosphate Oxidase/0.455
2g1r3IGRenin3.4.23.150.454
2g1s4IGRenin3.4.23.150.454
2y60M8FIsopenicillin N synthase1.21.3.10.454
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.454
4an4DUDPutative glycosyl transferase/0.454
1hb3SCVIsopenicillin N synthase1.21.3.10.453
1jqiFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial/0.453
4bb3KKAIsopenicillin N synthase1.21.3.10.453
1egdFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.452
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.452
2g8yNADHydroxycarboxylate dehydrogenase B/0.452
2jb4A14Isopenicillin N synthase1.21.3.10.452
3b1dPLSBetaC-S lyase/0.452
4oztP1AEcdysone receptor, putative/0.452
1ozpACOMycothiol acetyltransferase2.3.1.1890.451
2x8gFADThioredoxin glutathione reductase/0.451
4p13FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.451
1mhtSAHModification methylase HhaI2.1.1.370.450
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2fhnBNIAvidin-related protein 4/5/0.450
4euaCOASuccinyl-CoA:acetate CoA-transferase/0.450
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.450
4jx1CAHCamphor 5-monooxygenase1.14.15.10.450
4udqFAD5-(hydroxymethyl)furfural oxidase/0.450
5fm7ADPRuvB-like helicase/0.450
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.449
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.449
2pg0FADAcyl-CoA dehydrogenase/0.449
5ig2NADShort-chain dehydrogenase/reductase SDR/0.449
1bk0ACVIsopenicillin N synthase1.21.3.10.448
4rvgTYDD-mycarose 3-C-methyltransferase/0.448
1knrFADL-aspartate oxidase1.4.3.160.447
2fznFADBifunctional protein PutA1.5.5.20.447
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.447
1hb1OCVIsopenicillin N synthase1.21.3.10.446
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3f63GTXGlutathione transferase GST1-4/0.446
3ivcFG4Pantothenate synthetase6.3.2.10.446
3lsiFADPyranose 2-oxidase/0.446
3o26NDPSalutaridine reductase/0.446
3pndFADFAD:protein FMN transferase/0.446
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.446
4rquNADAlcohol dehydrogenase class-P/0.446
5er0FADUncharacterized NAD(FAD)-dependent dehydrogenase/0.446
1e3lNADAlcohol dehydrogenase 41.1.1.10.445
1il0NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.445
1qorNDPQuinone oxidoreductase 1/0.445
1tehNADAlcohol dehydrogenase class-31.1.1.10.445
1tl7FOKAdenylate cyclase type 2/0.445
1tl7FOKAdenylate cyclase type 5/0.445
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2z52H23Geranylgeranyl pyrophosphate synthase/0.445
3kybFADUDP-galactopyranose mutase5.4.99.90.445
3r9uFADThioredoxin reductase/0.445
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
1kp3ATPArgininosuccinate synthase6.3.4.50.444
1u65CP0Acetylcholinesterase3.1.1.70.444
3b6zCO7Enoyl reductase LovC10.444
4mo2FADUDP-galactopyranose mutase/0.444
4uugPXGBranched-chain amino acid aminotransferase, putative/0.444
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.443
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.443
2x8hFADThioredoxin glutathione reductase/0.443
3iocA5DPantothenate synthetase6.3.2.10.443
4mhtSAHModification methylase HhaI2.1.1.370.443
1g8oU5PN-acetyllactosaminide alpha-1,3-galactosyltransferase/0.442
2fmoFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.442
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.442
4i4z2NE1,4-dihydroxy-2-naphthoyl-CoA synthase/0.442
1d4dFADFumarate reductase flavoprotein subunit1.3.5.40.441
1piwNAPNADP-dependent alcohol dehydrogenase 61.1.1.20.441
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.441
2h2aDNDProbable nicotinate-nucleotide adenylyltransferase/0.441
2qtcTDKPyruvate dehydrogenase E1 component1.2.4.10.441
2xpvMIYTetracycline repressor protein class D/0.441
4ambDUDPutative glycosyl transferase/0.441
4ntcFADThioredoxin reductase gliT/0.441
4o8aFADBifunctional protein PutA1.2.1.880.441
4tvbNADHomospermidine synthase2.5.1.440.441
4y9qC2EUncharacterized protein/0.441
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
5esdTDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.441
1oqmUD2Beta-1,4-galactosyltransferase 1/0.440
2g9rG27Glycogen phosphorylase, muscle form2.4.1.10.440
2y6fM9FIsopenicillin N synthase1.21.3.10.440
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.440
2zevB71Geranylgeranyl pyrophosphate synthase/0.440
3wleNAD(R)-specific carbonyl reductase/0.440