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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1q3wATUGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1q3wATUGlycogen synthase kinase-3 beta2.7.11.261.000
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.569
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.561
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.549
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.547
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.540
3eb0DRKUncharacterized protein/0.533
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.527
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.525
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.524
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.523
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.522
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.518
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.516
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.515
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.515
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.509
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.509
2vu3LZECyclin-dependent kinase 22.7.11.220.503
4aguD15Cyclin-dependent kinase-like 1/0.502
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.501
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.499
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.496
4ez50RSCyclin-dependent kinase 62.7.11.220.496
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.495
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.495
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.495
4bcmT7ZCyclin-dependent kinase 22.7.11.220.494
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.493
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.492
4gmy0X5Tyrosine-protein kinase JAK2/0.490
4ix6ADPUncharacterized protein/0.490
1fvv107Cyclin-dependent kinase 22.7.11.220.489
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.489
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.488
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.487
3zep1NXTyrosine-protein kinase JAK32.7.10.20.487
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.486
2hog710Serine/threonine-protein kinase Chk12.7.11.10.486
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.486
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.486
3nux3NVCyclin-dependent kinase 62.7.11.220.485
2vd5BI8Myotonin-protein kinase2.7.11.10.483
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.482
1yvj4STTyrosine-protein kinase JAK32.7.10.20.482
2fvdLIACyclin-dependent kinase 22.7.11.220.482
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.482
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.482
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.482
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.481
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.481
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.480
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.480
3zh8C58Protein kinase C iota type2.7.11.130.480
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.480
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.480
4nka2K7Fibroblast growth factor receptor 1/0.480
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.479
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.479
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.479
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.479
2ckeIQUDeath-associated protein kinase 2/0.478
4f640S8Fibroblast growth factor receptor 1/0.478
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.477
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.477
1pkdUCNCyclin-dependent kinase 22.7.11.220.476
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.476
4jia1K3Tyrosine-protein kinase JAK2/0.476
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.475
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.475
4o0wADNAurora kinase A2.7.11.10.475
1wvxBD4Death-associated protein kinase 12.7.11.10.474
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.474
3q9xEMOCasein kinase II subunit alpha2.7.11.10.474
3u4uLNHCasein kinase II subunit alpha2.7.11.10.474
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.474
5e8ySTUTGF-beta receptor type-22.7.11.300.474
3a62STURibosomal protein S6 kinase beta-12.7.11.10.473
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.473
4hvi19STyrosine-protein kinase JAK32.7.10.20.473
4ic7ANPMitogen-activated protein kinase 72.7.11.240.473
2pmoHMDProtein kinase 7/0.472
3at4CCKCasein kinase II subunit alpha2.7.11.10.472
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.471
3nup3NUCyclin-dependent kinase 62.7.11.220.471
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.470
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.470
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.470
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.469
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.468
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.468
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.467
3du8553Glycogen synthase kinase-3 beta2.7.11.260.467
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.467
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.467
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.466
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.466
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.466
4cd0AWJALK tyrosine kinase receptor2.7.10.10.466
4g1wG1WMitogen-activated protein kinase 82.7.11.240.466
2pvhP19Casein kinase II subunit alpha2.7.11.10.465
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.465
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.465
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.464
2pvnP63Casein kinase II subunit alpha2.7.11.10.464
4aqc88ATyrosine-protein kinase JAK2/0.464
4bbfO19Tyrosine-protein kinase JAK2/0.464
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.464
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.464
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.463
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.463
4hvh19RTyrosine-protein kinase JAK32.7.10.20.463
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
2x6dX6DAurora kinase A2.7.11.10.462
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.462
3w2sW2REpidermal growth factor receptor2.7.10.10.462
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.462
1zrzBI1Protein kinase C iota type2.7.11.130.461
3r7iX9ICyclin-dependent kinase 22.7.11.220.461
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.461
4j97ACPFibroblast growth factor receptor 2/0.461
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.461
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.461
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.460
2j0m4STFocal adhesion kinase 12.7.10.20.460
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.460
3i60E86Mitogen-activated protein kinase 12.7.11.240.460
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.460
1finATPCyclin-dependent kinase 22.7.11.220.459
1k6tXN1Gag-Pol polyprotein3.4.23.160.459
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.458
3lpbNVBTyrosine-protein kinase JAK2/0.458
3zewSTUEphrin type-B receptor 42.7.10.10.458
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.458
4grb0XGCasein kinase II subunit alpha2.7.11.10.458
1m2pHNACasein kinase II subunit alpha2.7.11.10.457
2h96893Mitogen-activated protein kinase 82.7.11.240.457
2i40BLZCyclin-dependent kinase 22.7.11.220.457
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.457
4dtaADNAPH(2'')-Id/0.457
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.457
4wsqKSAAP2-associated protein kinase 12.7.11.10.457
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.456
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.456
3ncz3NCRho-associated protein kinase 12.7.11.10.456
3nwxKVSGag-Pol polyprotein3.4.23.160.456
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2eb3ANPEpidermal growth factor receptor2.7.10.10.455
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.455
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.455
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.455
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.454
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.454
3c4xATPRhodopsin kinase/0.454
4bbe3O4Tyrosine-protein kinase JAK2/0.454
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.454
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.454
1oecAA2Fibroblast growth factor receptor 2/0.453
2j7t274Serine/threonine-protein kinase 102.7.11.10.453
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.453
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4nks2M2Fibroblast growth factor receptor 1/0.453
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.452
2i0ePDSProtein kinase C beta type2.7.11.130.452
2pvmP29Casein kinase II subunit alpha2.7.11.10.452
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.452
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.452
3s4qNK0Mitogen-activated protein kinase 14/0.452
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.452
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.452
4c62XWWTyrosine-protein kinase JAK2/0.452
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.452
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.452
4qnaX11Serine/threonine-protein kinase 242.7.11.10.452
5aaaVGHALK tyrosine kinase receptor2.7.10.10.452
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.451
2wouZZFTGF-beta receptor type-12.7.11.300.451
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.451
3a7hATPSerine/threonine-protein kinase 242.7.11.10.451
3juhANPCasein kinase II subunit alpha2.7.11.10.451
3uvp048Mitogen-activated protein kinase 14/0.451
4f081RSTyrosine-protein kinase JAK2/0.451
4fob0USALK tyrosine kinase receptor2.7.10.10.451
4hge15VTyrosine-protein kinase JAK2/0.451
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.451
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.450
3c1y2BADNA integrity scanning protein DisA/0.450
3ezrEZRCyclin-dependent kinase 22.7.11.220.450
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.450
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.450
4l9i8PRRhodopsin kinase/0.450
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.449
5av2KMPDeath-associated protein kinase 12.7.11.10.449
1bygSTUTyrosine-protein kinase CSK/0.448
2bujSTUSerine/threonine-protein kinase 16/0.448
2cchATPCyclin-dependent kinase 22.7.11.220.448
2itqITQEpidermal growth factor receptor2.7.10.10.448
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.448
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.448
4c61LMMTyrosine-protein kinase JAK2/0.448
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.448
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.448
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.447
2uzbC75Cyclin-dependent kinase 22.7.11.220.447
2z2w770Wee1-like protein kinase2.7.10.20.447
3igoANPCalmodulin-domain protein kinase 1, putative/0.447
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.447
4dgmAGICasein kinase II subunit alpha2.7.11.10.447
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.447
4j98ACPFibroblast growth factor receptor 2/0.447
5cvfATPCasein kinase II subunit alpha2.7.11.10.447
1gii1PUCyclin-dependent kinase 22.7.11.220.446
2ijmADPFocal adhesion kinase 12.7.10.20.446
2io6330Wee1-like protein kinase2.7.10.20.446
3ezvEZVCyclin-dependent kinase 22.7.11.220.446
3lltANPProtein serine/threonine kinase-1/0.446
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
3wowANPCasein kinase II subunit alpha2.7.11.10.446
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.446
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.446
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.446
4jrvKJVEpidermal growth factor receptor2.7.10.10.446
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.446
1k6cMK1Gag-Pol polyprotein3.4.23.160.445
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.445
1xl2189Gag-Pol polyprotein3.4.23.160.445
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.445
2in6839Wee1-like protein kinase2.7.10.20.445
2izsBRQCasein kinase I isoform gamma-32.7.11.10.445
2yn8STUEphrin type-B receptor 42.7.10.10.445
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.445
3s1h56ZCyclin-dependent kinase 22.7.11.220.445
4b99R4LMitogen-activated protein kinase 72.7.11.240.445
4ccbOFGALK tyrosine kinase receptor2.7.10.10.445
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.445
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.445
4yaoFMNNADPH--cytochrome P450 reductase/0.445
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.444
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.444
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.444
3emg685Tyrosine-protein kinase SYK2.7.10.20.444
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.444
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.444
3w2rW2REpidermal growth factor receptor2.7.10.10.444
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.444
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.444
5cu6ATPCasein kinase II subunit alpha2.7.11.10.444
5e8xSTUTGF-beta receptor type-12.7.11.300.444
4z34ON7Lysophosphatidic acid receptor 1/0.444
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.443
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.443
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.443
2ojj82AMitogen-activated protein kinase 12.7.11.240.443
2pwlACPFibroblast growth factor receptor 2/0.443
3at3ATKCasein kinase II subunit alpha2.7.11.10.443
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.443
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.443
3tnwF18Cyclin-dependent kinase 22.7.11.220.443
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4fx360KCyclin-dependent kinase 22.7.11.220.443
4hyu1BKMitogen-activated protein kinase 82.7.11.240.443
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.442
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.442
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.442
4gk4L90Ephrin type-A receptor 32.7.10.10.442
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.442
4otiMI1Serine/threonine-protein kinase N1/0.442
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.441
3rak03ZCyclin-dependent kinase 22.7.11.220.441
4dgnLU2Casein kinase II subunit alpha2.7.11.10.441
4fv6E57Mitogen-activated protein kinase 12.7.11.240.441
4jbpYPHAurora kinase A2.7.11.10.441
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.441
4wboANWRhodopsin kinase/0.441
1u54ACPActivated CDC42 kinase 1/0.440
1vjy460TGF-beta receptor type-12.7.11.300.440
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.440
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2uxpCLMHTH-type transcriptional regulator TtgR/0.440
2vtqLZACyclin-dependent kinase 22.7.11.220.440
2xa4AZ5Tyrosine-protein kinase JAK2/0.440
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3be9P04Casein kinase II subunit alpha2.7.11.10.440
3js2VM1Fibroblast growth factor receptor 1/0.440
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.440
3vjoANPEpidermal growth factor receptor2.7.10.10.440
4bchT7ZCyclin-dependent kinase 92.7.11.220.440
4bgg844Activin receptor type-12.7.11.300.440
4hvg19QTyrosine-protein kinase JAK32.7.10.20.440
4jqeANPCasein kinase II subunit alpha2.7.11.10.440
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.440