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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1pu9COAHAT A1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1pu9COAHAT A1/1.000
1qsnCOAHAT A1/0.608
1puaCOAHAT A1/0.570
1cm0COAHistone acetyltransferase KAT2B2.3.1.480.528
1z4rACOHistone acetyltransferase KAT2A2.3.1.480.505
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.502
4bfxZVXPantothenate kinase2.7.1.330.498
4bb3KKAIsopenicillin N synthase1.21.3.10.497
5kf2ACOPredicted acetyltransferase/0.489
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.487
1mewXMPInosine-5'-monophosphate dehydrogenase/0.485
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.485
3eksCY9Actin-5C/0.485
2g1n1IGRenin3.4.23.150.482
3ekuCY9Actin-5C/0.480
2g247IGRenin3.4.23.150.479
1obnASVIsopenicillin N synthase1.21.3.10.478
3tfyCOAN-alpha-acetyltransferase 502.3.10.478
1b2lNDCAlcohol dehydrogenase1.1.1.10.477
4oztP1AEcdysone receptor, putative/0.477
1pqc444Oxysterols receptor LXR-beta/0.474
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.474
2g21L1BRenin3.4.23.150.473
1pq944BOxysterols receptor LXR-beta/0.471
2g1r3IGRenin3.4.23.150.471
4bftZVTPantothenate kinase2.7.1.330.471
2zsdCOAPantothenate kinase2.7.1.330.470
5cc9DDFDihydrofolate reductase1.5.1.30.469
1qiqACCIsopenicillin N synthase1.21.3.10.468
1x1bSAHC-20 methyltransferase/0.468
2cjfRP43-dehydroquinate dehydratase4.2.1.100.468
2g1y5IGRenin3.4.23.150.468
1x1dSAHC-20 methyltransferase/0.467
4uugPXGBranched-chain amino acid aminotransferase, putative/0.467
2ikuLIYRenin3.4.23.150.466
3fr5I4AFatty acid-binding protein, adipocyte/0.465
1xs7MMIBeta-secretase 13.4.23.460.464
1hb3SCVIsopenicillin N synthase1.21.3.10.463
2iviACWIsopenicillin N synthase1.21.3.10.463
2g1s4IGRenin3.4.23.150.462
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.462
4bfvZVVPantothenate kinase2.7.1.330.462
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.461
4n4v2GYTankyrase-12.4.2.300.461
5kgjACOPredicted acetyltransferase/0.461
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.460
2il2LIXRenin3.4.23.150.460
3d2mCOAAmino-acid acetyltransferase/0.460
3fktSIIBeta-secretase 13.4.23.460.460
3nn6HNK6-hydroxy-L-nicotine oxidase/0.460
5irnADPNucleotide binding oligomerization domain containing 2/0.460
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.459
2g226IGRenin3.4.23.150.459
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.459
2vjmCOAFormyl-CoA:oxalate CoA-transferase/0.459
3bgxMEFThymidylate synthase/0.459
3wleNAD(R)-specific carbonyl reductase/0.459
4y1bNAPAntE/0.459
1u1gBBBUridine phosphorylase2.4.2.30.458
3h2sNDPPutative NADH-flavin reductase/0.458
3rbqGLY_ALA_GLY_ALA_DAOProtein unc-119 homolog A/0.458
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.458
3zkyWT4Isopenicillin N synthase1.21.3.10.458
5kf8ACOPredicted acetyltransferase/0.458
1z7yAA5Cysteine synthase 12.5.1.470.457
2ed4NAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.457
2y60M8FIsopenicillin N synthase1.21.3.10.457
3ohh3HHBeta-secretase 13.4.23.460.457
3udq09EBeta-secretase 13.4.23.460.457
1trgCB3Thymidylate synthase/0.456
2vbpVB1Isopenicillin N synthase1.21.3.10.456
3udn09BBeta-secretase 13.4.23.460.456
4j0v1H7Beta-secretase 13.4.23.460.456
5c1mCLRMu-type opioid receptor/0.456
1blzACVIsopenicillin N synthase1.21.3.10.455
1hb1OCVIsopenicillin N synthase1.21.3.10.455
1hfqMOTDihydrofolate reductase1.5.1.30.455
1qjfACSIsopenicillin N synthase1.21.3.10.455
1txtCAAHMG-CoA synthase/0.455
1wuaAP8Actin, alpha skeletal muscle/0.455
2xy93ESAngiotensin-converting enzyme3.2.10.455
3rsv3RSBeta-secretase 13.4.23.460.455
3zoiM2WIsopenicillin N synthase1.21.3.10.455
4dk70KSOxysterols receptor LXR-beta/0.455
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.455
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.454
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.454
3emlZMAAdenosine receptor A2a/0.454
1bk0ACVIsopenicillin N synthase1.21.3.10.453
1lkeDOGBilin-binding protein/0.453
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.453
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.453
1nm6L86Prothrombin3.4.21.50.453
1svmATPLarge T antigen3.6.40.453
2ou2ACOHistone acetyltransferase KAT5/0.453
2pswCOAN-alpha-acetyltransferase 50/0.453
3nmpPYVAbscisic acid receptor PYL2/0.453
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.453
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.453
4k4fK4FTankyrase-12.4.2.300.453
1a9cGTPGTP cyclohydrolase 13.5.4.160.452
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.452
1yhjR6CPyridoxal kinase2.7.1.350.452
2hizLIJBeta-secretase 13.4.23.460.452
4dbs0HVAldo-keto reductase family 1 member C3/0.452
4zj8SUVOrexin receptor type 1/0.452
2g1o2IGRenin3.4.23.150.451
2hxzH7JCathepsin S3.4.22.270.451
2jb4A14Isopenicillin N synthase1.21.3.10.451
4b4w9L9Bifunctional protein FolD/0.451
4eb7PLPCysteine desulfurase IscS 2/0.451
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
4n1gCEIObelin/0.451
4q0kGA3Phytohormone-binding protein/0.451
2c9dPHR6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
2geuCOKPantothenate kinase2.7.1.330.450
2gv8NDPThiol-specific monooxygenase1.14.130.450
2qw034Z4-chlorobenzoyl CoA ligase/0.450
3wagTYDGlycosyltransferase/0.450
4dvi2IWTankyrase-12.4.2.300.450
5dw60T1Succinyl-CoA:acetate CoA-transferase/0.450
1e7qNAPGDP-L-fucose synthase/0.449
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.449
2p83MR0Beta-secretase 13.4.23.460.449
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.449
2vcmM11Isopenicillin N synthase1.21.3.10.449
3ndcSAHPrecorrin-4 C(11)-methyltransferase2.1.1.1330.449
3slkNDPPolyketide synthase extender module 2/0.449
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.449
5kf9ACOPredicted acetyltransferase/0.449
1s20NAD2,3-diketo-L-gulonate reductase1.1.1.1300.448
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.448
2gjnFMNNitronate monooxygenase1.13.12.160.448
2vbdV10Isopenicillin N synthase1.21.3.10.448
3a3yOBNSodium/potassium-transporting ATPase subunit alpha/0.448
3c3xNAPEugenol synthase 11.1.1.3180.448
3gw9VNILanosterol 14-alpha-demethylase/0.448
4g3jVNTLanosterol 14-alpha-demethylase/0.448
1n5vNOMActVA 6 protein/0.447
1o2g696Prothrombin3.4.21.50.447
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.447
2xvq9DSSerum albumin/0.447
3adaNADSubunit alpha of sarocosine oxidase/0.447
3oqkS52Renin3.4.23.150.447
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.447
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.447
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.447
1gvhFADFlavohemoprotein/0.446
1mj9COAHistone acetyltransferase ESA1/0.446
1x1cSAHC-20 methyltransferase/0.446
2ejzSAHDiphthine synthase/0.446
2givACOHistone acetyltransferase KAT8/0.446
2hm1LIQBeta-secretase 13.4.23.460.446
2zxgS23Aminopeptidase N3.4.11.20.446
3b1dPLSBetaC-S lyase/0.446
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3fhxPXLPyridoxal kinase2.7.1.350.446
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.446
3q9bB3NAcetylpolyamine amidohydrolase/0.446
3vf60H6Glucokinase2.7.1.20.446
4cf6CBDNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
4d89BXDBeta-secretase 13.4.23.460.446
4k38SAMAnaerobic sulfatase-maturating enzyme1.8.980.446
4ktl1CQCytochrome P450/0.446
2j3qTFLAcetylcholinesterase3.1.1.70.445
2lfoGCHFatty acid-binding protein, liver/0.445
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.445
3cb2GDPTubulin gamma-1 chain/0.445
3lpiZ74Beta-secretase 13.4.23.460.445
3skgPB8Beta-secretase 13.4.23.460.445
3zbzOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.445
4y0kNAPAntE/0.445
5dp2NAPCurF/0.445
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1p5rCOAFormyl-CoA:oxalate CoA-transferase/0.444
1tehNADAlcohol dehydrogenase class-31.1.1.10.444
2hp2KE4Glutamate-1-semialdehyde 2,1-aminomutase5.4.3.80.444
2iko7IGRenin3.4.23.150.444
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.444
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.444
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.444
3p0fBAUUridine phosphorylase 22.4.2.30.444
1bil0IURenin3.4.23.150.443
1bwsNDPGDP-L-fucose synthase/0.443
1mjaCOAHistone acetyltransferase ESA1/0.443
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2x7hPFNProstaglandin reductase 310.443
3br9DEYGenome polyprotein2.7.7.480.443
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.443
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
3iktNADRedox-sensing transcriptional repressor Rex/0.443
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.443
3lpkZ76Beta-secretase 13.4.23.460.443
3udk095Beta-secretase 13.4.23.460.443
4ejmNAPPutative zinc-binding dehydrogenase/0.443
4u0mGTPCyclic GMP-AMP synthase/0.443
2e0nSAHPrecorrin-2 C20-methyltransferase/0.442
2ob0ACON-alpha-acetyltransferase 50/0.442
2q1uNADPutative nucleotide sugar epimerase/ dehydratase/0.442
2wo7ASVIsopenicillin N synthase1.21.3.10.442
3l0lHC3Nuclear receptor ROR-gamma/0.442
3qt62P0Mevalonate diphosphate decarboxylase/0.442
3rdqDTBStreptavidin/0.442
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.442
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.442
4b68FADL-ornithine N(5)-monooxygenase/0.442
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.442
4ge90L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
4j1f1HLBeta-secretase 13.4.23.460.442
4jjiNADAlcohol dehydrogenase class-3/0.442
4nv10FXFormyl transferase/0.442
1mczRMNBenzoylformate decarboxylase4.1.1.70.441
1mjbACOHistone acetyltransferase ESA1/0.441
1w0kADPATP synthase subunit alpha, mitochondrial/0.441
1w0kADPATP synthase subunit beta, mitochondrial3.6.3.140.441
2c9bPUG6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
2ibwCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.441
2v16C47Renin3.4.23.150.441
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.441
3c1kT15Prothrombin3.4.21.50.441
3drcMTXDihydrofolate reductase1.5.1.30.441
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3q43D66M1 family aminopeptidase3.4.110.441
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.441
4fse0VABeta-secretase 13.4.23.460.441
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.441
5d4uSAMUncharacterized protein MJ0489/0.441
5ej4TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.441
1fy7COAHistone acetyltransferase ESA1/0.440
1lb9DNQGlutamate receptor 2/0.440
1qorNDPQuinone oxidoreductase 1/0.440
1xp8AGSProtein RecA/0.440
2cftPLPPyridoxal phosphate phosphatase/0.440
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.440
3fsjD7KBenzoylformate decarboxylase4.1.1.70.440
3hhu819Heat shock protein HSP 90-alpha/0.440
3v2uATPProtein GAL3/0.440
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.440
4b65FADL-ornithine N(5)-monooxygenase/0.440
4ips1G4Mycocyclosin synthase1.14.21.90.440
4k36SAMAnaerobic sulfatase-maturating enzyme1.8.980.440
4ktkKTKCytochrome P450/0.440
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.440
4s0vSUVOrexin receptor type 2/0.440