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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1pq944BOxysterols receptor LXR-beta

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1pq944BOxysterols receptor LXR-beta/1.000
1pqc444Oxysterols receptor LXR-beta/0.725
1upw444Oxysterols receptor LXR-beta/0.586
4dk70KSOxysterols receptor LXR-beta/0.555
1p8dCO1Oxysterols receptor LXR-beta/0.545
2aclL05Oxysterols receptor LXR-alpha/0.517
3ipuO40Oxysterols receptor LXR-alpha/0.513
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.507
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.503
1pq6965Oxysterols receptor LXR-beta/0.494
4bfuZVUPantothenate kinase2.7.1.330.492
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.489
4iaq2GM5-hydroxytryptamine receptor 1B/0.487
3ipq965Oxysterols receptor LXR-alpha/0.485
3gkjHC3Niemann-Pick C1 protein/0.483
5dozNDPJamJ/0.483
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.481
3eksCY9Actin-5C/0.480
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.479
2xviFADPutative flavin-containing monooxygenase/0.477
3fhxPXLPyridoxal kinase2.7.1.350.476
5dp2NAPCurF/0.475
4bfxZVXPantothenate kinase2.7.1.330.474
4iarERM5-hydroxytryptamine receptor 1B/0.472
1ygjRMCPyridoxal kinase2.7.1.350.471
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.468
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.467
1vyrFMNPentaerythritol tetranitrate reductase/0.467
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
2vkeTACTetracycline repressor protein class D/0.467
3zkyWT4Isopenicillin N synthase1.21.3.10.467
1d6w00RProthrombin3.4.21.50.466
1x8lOXRRetinol dehydratase/0.466
2f3815MAldo-keto reductase family 1 member C3/0.466
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.466
5k2bZMAAdenosine receptor A2a/0.466
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.465
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.464
1d3pBT3Prothrombin3.4.21.50.464
1obnASVIsopenicillin N synthase1.21.3.10.464
1s7gNADNAD-dependent protein deacylase 2/0.464
2uuk897Prothrombin3.4.21.50.464
4jqh1MFAlr2278 protein/0.464
1xdsDRAAclacinomycin 10-hydroxylase RdmB4.1.10.463
3q7fED2Uncharacterized protein/0.463
4phlPILPhosphodiesterase/0.463
5jy1NADPutative short-chain dehydrogenase/reductase/0.463
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.462
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.462
2pg0FADAcyl-CoA dehydrogenase/0.462
3pm9FADPutative oxidoreductase/0.462
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.461
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.461
1knpFADL-aspartate oxidase1.4.3.160.461
4v2gITCTetracycline repressor protein class D/0.461
3emlZMAAdenosine receptor A2a/0.461
1bk0ACVIsopenicillin N synthase1.21.3.10.460
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.460
4glx0XSDNA ligase6.5.1.20.460
4bfwZVWPantothenate kinase2.7.1.330.459
1nhkCMPNucleoside diphosphate kinase2.7.4.60.458
3cr0809Wee1-like protein kinase2.7.10.20.458
3slkNDPPolyketide synthase extender module 2/0.458
1blzACVIsopenicillin N synthase1.21.3.10.457
1kkq471Peroxisome proliferator-activated receptor alpha/0.457
1xf0ASDAldo-keto reductase family 1 member C3/0.457
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.457
3gkiCLRNiemann-Pick C1 protein/0.457
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.457
4gxs0YSGlutamate receptor 2/0.457
4l5b1UXDeoxycytidine kinase2.7.1.740.457
4rn615UProthrombin3.4.21.50.457
2y60M8FIsopenicillin N synthase1.21.3.10.456
4g7gVFVLanosterol 14-alpha-demethylase/0.456
4n3l2FNProthrombin3.4.21.50.456
1odcA8BAcetylcholinesterase3.1.1.70.455
1z71L17Prothrombin3.4.21.50.455
2bu9HFVIsopenicillin N synthase1.21.3.10.455
2getCOKPantothenate kinase2.7.1.330.455
2vbdV10Isopenicillin N synthase1.21.3.10.455
2vbpVB1Isopenicillin N synthase1.21.3.10.455
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.455
1h50FMNPentaerythritol tetranitrate reductase/0.454
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
1d3dBZTProthrombin3.4.21.50.453
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.453
2zhw12UProthrombin3.4.21.50.453
4g3jVNTLanosterol 14-alpha-demethylase/0.453
4nieNBHNuclear receptor ROR-gamma/0.453
1knrFADL-aspartate oxidase1.4.3.160.452
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.452
1yc2NADNAD-dependent protein deacylase 2/0.452
2fjdSFDAdenylylsulfate reductase, subunit A (AprA)/0.452
2iviACWIsopenicillin N synthase1.21.3.10.452
2x6o2TCTetracycline repressor protein class D/0.452
2y6fM9FIsopenicillin N synthase1.21.3.10.452
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.452
4bb3KKAIsopenicillin N synthase1.21.3.10.452
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.452
4u8iFDAUDP-galactopyranose mutase/0.452
1oc1ASVIsopenicillin N synthase1.21.3.10.451
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.451
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.451
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.451
3hl0NADMaleylacetate reductase/0.451
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.451
3qm4PN0Cytochrome P450 2D6/0.451
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
4jjiNADAlcohol dehydrogenase class-3/0.451
5iu86DZAdenosine receptor A2a/0.451
5k2cZMAAdenosine receptor A2a/0.451
1hb1OCVIsopenicillin N synthase1.21.3.10.450
1xddAAYIntegrin alpha-L/0.450
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
2jb4A14Isopenicillin N synthase1.21.3.10.450
2rr1W8RGenome polyprotein/0.450
2zc922UProthrombin3.4.21.50.450
3d91REMRenin3.4.23.150.450
3p62FMNPentaerythritol tetranitrate reductase/0.450
3vsxR32Renin3.4.23.150.450
4jbtASDCytochrome P450 monooxygenase/0.450
1qiqACCIsopenicillin N synthase1.21.3.10.449
1v35NAIEnoyl-ACP reductase/0.449
1xzqFONtRNA modification GTPase MnmE3.6.50.449
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.449
2po7CHDFerrochelatase, mitochondrial4.99.1.10.449
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3ey4352Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3q9bB3NAcetylpolyamine amidohydrolase/0.449
4d03NAPPhenylacetone monooxygenase1.14.13.920.449
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.449
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2ikuLIYRenin3.4.23.150.448
3gw9VNILanosterol 14-alpha-demethylase/0.448
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.448
3ol5SAWCamphor 5-monooxygenase1.14.15.10.448
3sf6FDAGlutaryl-CoA dehydrogenase/0.448
3vtbTKAVitamin D3 receptor/0.448
1cjtFOKAdenylate cyclase type 2/0.447
1cjtFOKAdenylate cyclase type 5/0.447
1hb3SCVIsopenicillin N synthase1.21.3.10.447
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2cf9348Prothrombin3.4.21.50.447
2iyaZIOOleandomycin glycosyltransferase/0.447
3biz61EWee1-like protein kinase2.7.10.20.447
3coz54HPantothenate synthetase6.3.2.10.447
3oafOAGDihydrofolate reductase1.5.1.30.447
3zeiAWHO-acetylserine sulfhydrylase/0.447
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
4c5oFADPutative monooxygenase/0.447
4kbyC2EStimulator of interferon genes protein/0.447
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.446
1zgbA1EAcetylcholinesterase3.1.1.70.446
1zq5E04Aldo-keto reductase family 1 member C3/0.446
2g1o2IGRenin3.4.23.150.446
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3tdaPN0Cytochrome P450 2D6/0.446
3vf60H6Glucokinase2.7.1.20.446
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.446
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4yfy0FXVioF/0.446
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.446
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.445
1yhjR6CPyridoxal kinase2.7.1.350.445
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.445
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.445
2gevCOKPantothenate kinase2.7.1.330.445
2hdjNDPAldo-keto reductase family 1 member C2/0.445
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3f1kNAPUncharacterized oxidoreductase YciK10.445
3ha7B32Hydroxymycolate synthase MmaA42.1.10.445
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.445
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.445
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
4oztP1AEcdysone receptor, putative/0.445
1b2lNDCAlcohol dehydrogenase1.1.1.10.444
1fmlRTLRetinol dehydratase/0.444
1oj4CDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.444
1qjfACSIsopenicillin N synthase1.21.3.10.444
1w4lGL8Acetylcholinesterase3.1.1.70.444
1z6tADPApoptotic protease-activating factor 1/0.444
2jh6894Prothrombin3.4.21.50.444
2r0pK2CPutative FAD-monooxygenase/0.444
2v13C40Renin3.4.23.150.444
2zb8IMNProstaglandin reductase 21.3.1.480.444
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.444
4bj9UHBTankyrase-22.4.2.300.444
4iah1DXAlr2278 protein/0.444
1qorNDPQuinone oxidoreductase 1/0.443
1x1cSAHC-20 methyltransferase/0.443
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.443
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.443
3c3xNAPEugenol synthase 11.1.1.3180.443
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.443
4g1z0VPVitamin D3 receptor A/0.443
4j6cSTRCytochrome P450 monooxygenase/0.443
1c4yIH3Prothrombin3.4.21.50.442
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.442
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.442
1t2cNAIL-lactate dehydrogenase1.1.1.270.442
1ta6177Prothrombin3.4.21.50.442
1xu9CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
1ypjUIBProthrombin3.4.21.50.442
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.442
2r6jNDPEugenol synthase 11.1.1.3180.442
3a783EVVitamin D3 receptor/0.442
3q44D50M1 family aminopeptidase3.4.110.442
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.442
4bftZVTPantothenate kinase2.7.1.330.442
4bfvZVVPantothenate kinase2.7.1.330.442
4g95OAGDihydrofolate reductase1.5.1.30.442
1eioGCHGastrotropin/0.441
1h36R88Squalene--hopene cyclase4.2.1.1290.441
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
1tl7FOKAdenylate cyclase type 2/0.441
1tl7FOKAdenylate cyclase type 5/0.441
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2i4qUA4Renin3.4.23.150.441
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.441
2uxoTACHTH-type transcriptional regulator TtgR/0.441
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.441
3atzFMNProstaglandin F2a synthase/0.441
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.441
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.441
4j6bPLOCytochrome P450 monooxygenase/0.441
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.441
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1yplRA8Prothrombin3.4.21.50.440
2hejNDPAldo-keto reductase family 1 member C211.1.10.440
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3ekuCY9Actin-5C/0.440
3nx4NAPPutative oxidoreductase/0.440
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.440
3up3XCAaceDAF-12/0.440
3utfFDAUDP-galactopyranose mutase/0.440
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.440
4h1q0XXMatrix metalloproteinase-93.4.24.350.440
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.440
4psbGA3Cytokinin-specific binding protein/0.440