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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.11.000
5cnoANPEpidermal growth factor receptor2.7.10.10.513
5e8ySTUTGF-beta receptor type-22.7.11.300.508
5e92ANPTGF-beta receptor type-22.7.11.300.507
3bu5ATPInsulin receptor2.7.10.10.506
4k33ACPFibroblast growth factor receptor 32.7.10.10.506
3nieANPMitogen-activated protein kinase/0.497
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.496
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.495
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.495
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.489
4j95ACPFibroblast growth factor receptor 2/0.487
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.485
3gu7ADPDeath-associated protein kinase 12.7.11.10.484
4lfiGNPCasein kinase II subunit alpha2.7.11.10.484
4ysjADPCalmodulin-like domain protein kinase/0.484
4deeADPAurora kinase A2.7.11.10.480
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.479
5cnnANPEpidermal growth factor receptor2.7.10.10.477
1pmn984Mitogen-activated protein kinase 102.7.11.240.476
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.476
4qnyANPMitogen activated protein kinase, putative/0.476
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.475
3i60E86Mitogen-activated protein kinase 12.7.11.240.473
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.473
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.472
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.471
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.469
1u54ACPActivated CDC42 kinase 1/0.469
3oom507Activin receptor type-12.7.11.300.468
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.468
5dosATPAurora kinase A2.7.11.10.468
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.467
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.465
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.464
4j99ACPFibroblast growth factor receptor 2/0.464
5dnrATPAurora kinase A2.7.11.10.464
3gubGUBDeath-associated protein kinase 12.7.11.10.463
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.463
4xlvACPInsulin receptor2.7.10.10.463
4dymIYZActivin receptor type-12.7.11.300.461
4fmqANPMitogen-activated protein kinase 12.7.11.240.461
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.460
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
2w4jADPDeath-associated protein kinase 12.7.11.10.459
3kvxFMYMitogen-activated protein kinase 102.7.11.240.459
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.459
3w32W32Epidermal growth factor receptor2.7.10.10.459
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.459
4h3qANPMitogen-activated protein kinase 12.7.11.240.458
4riyADPEpidermal growth factor receptor2.7.10.10.458
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.457
2b7aIZATyrosine-protein kinase JAK2/0.457
2henADPEphrin type-B receptor 22.7.10.10.457
3oriAGSSerine/threonine protein kinase/0.457
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.455
5av2KMPDeath-associated protein kinase 12.7.11.10.455
2xneASHAurora kinase A2.7.11.10.454
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.454
3hmm855TGF-beta receptor type-12.7.11.300.454
4gmy0X5Tyrosine-protein kinase JAK2/0.454
1b38ATPCyclin-dependent kinase 22.7.11.220.452
1jnkANPMitogen-activated protein kinase 102.7.11.240.452
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.452
4btjADPTau-tubulin kinase 12.7.11.10.452
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.452
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.451
3igoANPCalmodulin-domain protein kinase 1, putative/0.451
3t8oATPRhodopsin kinase/0.451
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.450
5e8wSTUTGF-beta receptor type-12.7.11.300.450
1bygSTUTyrosine-protein kinase CSK/0.449
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
2hog710Serine/threonine-protein kinase Chk12.7.11.10.449
3ttjJBIMitogen-activated protein kinase 102.7.11.240.449
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.449
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
1oitHDTCyclin-dependent kinase 22.7.11.220.448
2j0lANPFocal adhesion kinase 12.7.10.20.448
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.448
3c4zADPRhodopsin kinase/0.448
3k5uPFQAurora kinase A2.7.11.10.448
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.448
4hge15VTyrosine-protein kinase JAK2/0.448
4zseANPEpidermal growth factor receptor2.7.10.10.448
1h0w207Cyclin-dependent kinase 22.7.11.220.447
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3mtfA3FActivin receptor type-12.7.11.300.447
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.447
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.447
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.447
4bgg844Activin receptor type-12.7.11.300.447
4c57FEFCyclin-G-associated kinase2.7.11.10.447
1dawANPCasein kinase II subunit alpha2.7.11.10.446
1qmzATPCyclin-dependent kinase 22.7.11.220.446
2x1nX1NCyclin-dependent kinase 22.7.11.220.446
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
1hckATPCyclin-dependent kinase 22.7.11.220.445
3dfcANPDeath-associated protein kinase 12.7.11.10.445
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.445
4fv6E57Mitogen-activated protein kinase 12.7.11.240.445
1ir3ANPInsulin receptor2.7.10.10.444
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.444
2y9qANPMitogen-activated protein kinase 12.7.11.240.444
4eor4SPCyclin-dependent kinase 22.7.11.220.444
1ol5ADPAurora kinase A2.7.11.10.443
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.443
3lltANPProtein serine/threonine kinase-1/0.443
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.443
5av3KMPDeath-associated protein kinase 12.7.11.10.443
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.442
2qo9ANPEphrin type-A receptor 32.7.10.10.442
2r3iSCFCyclin-dependent kinase 22.7.11.220.442
3c4wATPRhodopsin kinase/0.442
3orkAGSSerine/threonine protein kinase/0.442
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.442
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.442
2ijmATPFocal adhesion kinase 12.7.10.20.441
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.441
4y93746Tyrosine-protein kinase/0.441
3clyACPFibroblast growth factor receptor 2/0.440
3gxlQIGTGF-beta receptor type-12.7.11.300.440
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.440
4o0uADNAurora kinase A2.7.11.10.440
4utdACPAurora kinase A2.7.11.10.440
5dt4ATPAurora kinase A2.7.11.10.440