scPDB - Distribution of Binding site Similarity values of 1pd8 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1pd8	CO4	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	1.000
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.740
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.674
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.615
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.614
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.614
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.602
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.601
1dlr	MXA	Dihydrofolate reductase	1.5.1.3	0.598
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.598
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.594
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.593
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.586
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.585
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.583
4ddr	MMV	Dihydrofolate reductase	1.5.1.3	0.581
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.578
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.572
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.569
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.560
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.559
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.558
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.557
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.556
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.555
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.554
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.552
1s3w	TQT	Dihydrofolate reductase	1.5.1.3	0.551
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.551
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.550
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.548
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.547
3nxo	D2B	Dihydrofolate reductase	1.5.1.3	0.546
3nxy	D2H	Dihydrofolate reductase	1.5.1.3	0.546
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.545
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.543
4qjc	IXE	Dihydrofolate reductase	1.5.1.3	0.543
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.542
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.538
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.534
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.533
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.530
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.528
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.525
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.523
4qa0	SHH	Histone deacetylase 8	3.5.1.98	0.518
3qly	55V	Uncharacterized protein	/	0.515
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.513
3cse	N22	Uncharacterized protein	/	0.505
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.505
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.502
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.501
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.495
4kfj	FOL	Dihydrofolate reductase	1.5.1.3	0.495
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.494
1dr4	HBI	Dihydrofolate reductase	1.5.1.3	0.490
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.482
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.482
1vrq	FON	Subunit alpha of sarocosine oxidase	/	0.481
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.480
3qlx	QLR	Uncharacterized protein	/	0.479
1yho	TRR	Dihydrofolate reductase	1.5.1.3	0.477
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.475
3ezp	B3N	Histone deacetylase 8	3.5.1.98	0.475
3rg9	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.474
1o6q	R17	Squalene--hopene cyclase	4.2.1.129	0.473
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.473
4qa2	SHH	Histone deacetylase 8	3.5.1.98	0.471
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.470
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.469
2f38	15M	Aldo-keto reductase family 1 member C3	/	0.469
4h98	14Q	Uncharacterized protein	/	0.469
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.468
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.468
4qa1	B3N	Histone deacetylase 8	3.5.1.98	0.468
3eej	53R	Uncharacterized protein	/	0.467
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.467
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.466
1ry0	PG2	Aldo-keto reductase family 1 member C3	/	0.465
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.464
1ry8	RUT	Aldo-keto reductase family 1 member C3	/	0.463
3eel	53T	Uncharacterized protein	/	0.461
3uza	T4G	Adenosine receptor A2a	/	0.461
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.460
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.459
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.459
1u70	MTX	Dihydrofolate reductase	1.5.1.3	0.458
3u8h	BHP	Phospholipase A2, membrane associated	/	0.458
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.456
1zq5	E04	Aldo-keto reductase family 1 member C3	/	0.455
4bbh	YBN	Glycylpeptide N-tetradecanoyltransferase	/	0.455
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.455
1zg3	2HI	Isoflavone 4'-O-methyltransferase	/	0.454
3pqb	VGP	Putative oxidoreductase	/	0.454
3t8x	T8X	T-cell surface glycoprotein CD1b	/	0.454
4iar	ERM	5-hydroxytryptamine receptor 1B	/	0.454
3rfm	CFF	Adenosine receptor A2a	/	0.454
1h35	R01	Squalene--hopene cyclase	4.2.1.129	0.453
1pkf	EPD	Epothilone C/D epoxidase	1.14	0.453
1zkn	IBM	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.453
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.453
1ej3	CZH	Aequorin-2	/	0.452
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.452
1w22	NHB	Histone deacetylase 8	3.5.1.98	0.451
2fm5	M99	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.451
3eek	53S	Uncharacterized protein	/	0.450
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.450
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.449
1xom	CIO	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.449
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.448
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.448
3ox3	4X4	Ribosyldihydronicotinamide dehydrogenase [quinone]	/	0.448
3uzw	NAP	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.448
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.448
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.447
1u71	MXA	Dihydrofolate reductase	1.5.1.3	0.446
3qlz	QLZ	Uncharacterized protein	/	0.446
1z4i	UMP	5'(3')-deoxyribonucleotidase, mitochondrial	3.1.3	0.445
3nhf	VVV	Ribosyldihydronicotinamide dehydrogenase [quinone]	/	0.445
1fdu	EST	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.444
1fdw	EST	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.443
4bfu	ZVU	Pantothenate kinase	2.7.1.33	0.443
4j6d	TES	Cytochrome P450 monooxygenase	/	0.443
4iaq	2GM	5-hydroxytryptamine receptor 1B	/	0.442
4b2g	V1N	Uncharacterized protein	/	0.441
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.441
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.441
4hf4	15H	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.441
1frb	ZST	Aldose reductase-related protein 2	/	0.440
2ouy	CMP	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.440
4tti	FMC	Purine nucleoside phosphorylase DeoD-type	/	0.440