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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1p9bIMOAdenylosuccinate synthetase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1p9bIMOAdenylosuccinate synthetase/1.000
1qf4RPDAdenylosuccinate synthetase/0.640
2gcqDOIAdenylosuccinate synthetase/0.609
1cg1IMOAdenylosuccinate synthetase/0.605
1cg4IMOAdenylosuccinate synthetase/0.603
1cg3IMOAdenylosuccinate synthetase/0.601
1cg0IMOAdenylosuccinate synthetase/0.597
1qf5RPLAdenylosuccinate synthetase/0.597
2dgnDOIAdenylosuccinate synthetase isozyme 1/0.597
1nhtPGSAdenylosuccinate synthetase/0.593
1kszPGSAdenylosuccinate synthetase/0.587
1lonIMOAdenylosuccinate synthetase isozyme 1/0.572
3vfqAR6Poly [ADP-ribose] polymerase 142.4.2.300.483
3f3sNADLambda-crystallin homolog/0.475
1bim0QBRenin3.4.23.150.471
2bfqAR6[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.471
3r95ACOMccE protein/0.471
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.470
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.470
4fn4NADShort chain dehydrogenase/0.469
4oztP1AEcdysone receptor, putative/0.467
4bfxZVXPantothenate kinase2.7.1.330.466
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.465
4dpwAGSMevalonate diphosphate decarboxylase/0.465
1xddAAYIntegrin alpha-L/0.464
2uuvFADAlkyldihydroxyacetonephosphate synthase2.5.1.260.464
2y0mACOHistone acetyltransferase KAT8/0.464
1lbcCYZGlutamate receptor 2/0.463
3d3wNAPL-xylulose reductase1.1.1.100.463
3gqvNAPEnoyl reductase LovC10.463
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.463
3k4cFADPyranose 2-oxidase/0.462
3q71AR6Poly [ADP-ribose] polymerase 142.4.2.300.461
4lcjNADC-terminal-binding protein 2/0.461
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.460
1g1aNADdTDP-glucose 4,6-dehydratase/0.459
3pm9FADPutative oxidoreductase/0.459
4bftZVTPantothenate kinase2.7.1.330.459
2c29NAPDihydroflavonol 4-reductase/0.457
4d86ADPPoly [ADP-ribose] polymerase 142.4.2.300.457
4irnFADAnaB/0.457
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.456
1vzaUMPThymidylate synthase/0.456
3qwbNDPProbable quinone oxidoreductase1.6.5.50.456
1aa6MGDFormate dehydrogenase H1.1.99.330.455
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.455
2c20NADUDP-glucose 4-epimerase/0.455
2ebaFADPutative glutaryl-CoA dehydrogenase/0.455
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.455
5hsaFASAlcohol oxidase 11.1.3.130.455
1fy7COAHistone acetyltransferase ESA1/0.454
1qrpHH0Pepsin A-43.4.23.10.454
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.454
3gw9VNILanosterol 14-alpha-demethylase/0.454
1t2cNAIL-lactate dehydrogenase1.1.1.270.453
1yqxNAPSinapyl alcohol dehydrogenase/0.453
3bg7FADPyranose 2-oxidase/0.453
1ma0NADAlcohol dehydrogenase class-31.1.1.10.452
1qorNDPQuinone oxidoreductase 1/0.452
3cosNADAlcohol dehydrogenase 41.1.1.10.452
3fpzAHZThiamine thiazole synthase/0.452
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.451
3tvuB37Acetyl-CoA carboxylase/0.451
4ambDUDPutative glycosyl transferase/0.451
4dxhNAJAlcohol dehydrogenase E chain1.1.1.10.451
1lnyIMOAdenylosuccinate synthetase isozyme 1/0.450
2q4bNAPUncharacterized protein At5g02240/0.450
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.450
3rpeFADPutative modulator of drug activity/0.450
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.449
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.449
1mjbACOHistone acetyltransferase ESA1/0.449
1rwbNADGlucose 1-dehydrogenase1.1.1.470.449
2ejjSAHDiphthine synthase/0.449
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.449
3junAKDPhenazine biosynthesis protein A/B/0.449
3qlrNDPDihydrofolate reductase1.5.1.30.449
4an4DUDPutative glycosyl transferase/0.449
4eb7PLPCysteine desulfurase IscS 2/0.449
4iv6FDAIsovaleryl-CoA dehydrogenase/0.449
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.449
1u3cFADCryptochrome-1/0.448
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.448
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.448
3owaFADAcyl-CoA dehydrogenase/0.448
3vyeVYERenin3.4.23.150.448
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.448
5cdtNAJAlcohol dehydrogenase E chain1.1.1.10.448
2fzwNADAlcohol dehydrogenase class-31.1.1.10.447
2xhd7T9Glutamate receptor 2/0.447
3oibFDAPutative acyl-CoA dehydrogenase/0.447
3pfdFDAAcyl-CoA dehydrogenase FadE25/0.447
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.447
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.447
1f0xFADD-lactate dehydrogenase1.1.1.280.446
1ipeNDPTropinone reductase 21.1.1.2360.446
1ldeNADAlcohol dehydrogenase E chain1.1.1.10.446
1obnASVIsopenicillin N synthase1.21.3.10.446
2g1o2IGRenin3.4.23.150.446
3tneRITCandidapepsin-13.4.23.240.446
3uylTYDProbable NDP-rhamnosyltransferase/0.446
5kjfNAJAlcohol dehydrogenase E chain1.1.1.10.446
1bk0ACVIsopenicillin N synthase1.21.3.10.445
1p0fNAPNADP-dependent alcohol dehydrogenase1.1.1.20.445
1ty8ADPProbable ADP-ribose 1''-phosphate phosphatase YML087W3.1.3.840.445
2zb3NDPProstaglandin reductase 21.3.1.480.445
3b6zCO7Enoyl reductase LovC10.445
3r7kFDAProbable acyl CoA dehydrogenase/0.445
5dp2NAPCurF/0.445
1e3eNAIAlcohol dehydrogenase 41.1.1.10.444
1mg5NAIAlcohol dehydrogenase1.1.1.10.444
1osvCHCBile acid receptor/0.444
4bfsZVSPantothenate kinase2.7.1.330.444
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.444
4q71FADBifunctional protein PutA/0.444
4yagNAIC alpha-dehydrogenase/0.444
4yaiNAIC alpha-dehydrogenase/0.444
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.443
1n7hNDPGDP-mannose 4,6 dehydratase 24.2.1.470.443
2e8rSAHDiphthine synthase/0.443
2ou2ACOHistone acetyltransferase KAT5/0.443
2v13C40Renin3.4.23.150.443
2xx91NFGlutamate receptor 2/0.443
3a3gDLZLumazine protein/0.443
3ieuGDPGTPase Era/0.443
3lqfNADGalactitol dehydrogenase/0.443
3nxxNDPDihydrofolate reductase1.5.1.30.443
4acxS8ZBeta-secretase 13.4.23.460.443
4bb3KKAIsopenicillin N synthase1.21.3.10.443
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.443
4ewo996Beta-secretase 13.4.23.460.443
4gxs0YSGlutamate receptor 2/0.443
4kcfAKMFAD-dependent oxidoreductase/0.443
4kqqVPPPeptidoglycan D,D-transpeptidase FtsI/0.443
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.442
1tqf32PBeta-secretase 13.4.23.460.442
2gjlFMNNitronate monooxygenase1.13.12.160.442
2po7CHDFerrochelatase, mitochondrial4.99.1.10.442
2vbdV10Isopenicillin N synthase1.21.3.10.442
3lpkZ76Beta-secretase 13.4.23.460.442
4b1rITCTetracycline repressor protein class D/0.442
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.442
5dbfNDPIridoid synthase1.3.1.990.442
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.442
1mjaCOAHistone acetyltransferase ESA1/0.441
2j83BATUlilysin3.4.240.441
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.441
3mx5UTPNucleoprotein/0.441
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.441
3r96ACOMccE protein/0.441
3uceNDPDehydrogenase/0.441
4dfg0JVGag-Pol polyprotein3.4.23.160.441
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.441
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.440
1ot7IU5Bile acid receptor/0.440
2bu9HFVIsopenicillin N synthase1.21.3.10.440
2c0cNAPProstaglandin reductase 310.440
2owkSAHDiphthine synthase/0.440
2y3rTRKTamL/0.440
4dshFDAUncharacterized protein/0.440
4f4qFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.440
5jscFADPutative acyl-CoA dehydrogenase/0.440