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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1onpFOM1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.267

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1onpFOM1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2671.000
1x1rGDPRas-related protein M-Ras/0.499
2db3ANPATP-dependent RNA helicase vasa, isoform A3.6.4.130.482
1kf6FADFumarate reductase flavoprotein subunit1.3.5.40.478
3wv9FEGHmd co-occurring protein HcgE/0.475
1wc5APCAdenylate cyclase/0.473
2w9hTOPDihydrofolate reductase1.5.1.30.467
5c2tFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.467
1n08ADPRiboflavin kinase2.7.1.260.466
3zkbANPDNA gyrase subunit B/0.466
1obnASVIsopenicillin N synthase1.21.3.10.462
1wc6TATAdenylate cyclase/0.461
2v3aFADRubredoxin-NAD(+) reductase1.18.1.10.461
3c36KAIGlutamate receptor ionotropic, kainate 1/0.461
3s3tATPUniversal stress protein/0.461
3zhzFM71-deoxy-D-xylulose 5-phosphate reductoisomerase/0.460
3p62FMNPentaerythritol tetranitrate reductase/0.459
4a84DXCMajor pollen allergen Bet v 1-A/0.458
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4kx6FADFumarate reductase flavoprotein subunit1.3.5.40.458
1kp3ATPArgininosuccinate synthase6.3.4.50.457
1obbNADAlpha-glucosidase3.2.1.200.457
2y85137Phosphoribosyl isomerase A5.3.1.160.457
4nu5NADPhosphonate dehydrogenase1.20.1.10.457
2v59LZKBiotin carboxylase6.3.4.140.456
1n06ADPRiboflavin kinase2.7.1.260.455
2du2FMNLactate oxidase/0.455
2oapANPType II secretion system protein (GspE-2)/0.455
4b1uLABActin, alpha skeletal muscle/0.455
2b0qADPAminoglycoside 3'-phosphotransferase2.7.1.950.454
4fqsLYAThymidylate synthase ThyA/0.454
1vikBAYGag-Pol polyprotein/0.453
3ae4FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.453
3zhxFM61-deoxy-D-xylulose 5-phosphate reductoisomerase/0.453
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.453
1j21ATPArgininosuccinate synthase/0.452
4ii5ADPCyclin-dependent kinase 22.7.11.220.452
1kvsUPGUDP-glucose 4-epimerase5.1.3.20.451
1y52BTNAvidin-related protein 4/5/0.451
2od7A1RNAD-dependent protein deacetylase HST23.5.10.451
4ytnFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.451
1h74AGSHomoserine kinase2.7.1.390.450
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.450
3zeiAWHO-acetylserine sulfhydrylase/0.450
1hb1OCVIsopenicillin N synthase1.21.3.10.449
2ckeIQUDeath-associated protein kinase 2/0.449
2e77FMNLactate oxidase/0.449
4q15HFGProline--tRNA ligase6.1.1.150.449
3whaWHAHeat shock protein HSP 90-alpha/0.448
4a6nFADTetX family tetracycline inactivation enzyme/0.448
4fxfATPPyruvate kinase PKM2.7.1.400.448
4nesUD1UDP-N-acetylglucosamine 2-epimerase5.1.3.140.448
4zlaBESCytosol aminopeptidase3.4.11.10.448
1j1zATPArgininosuccinate synthase/0.447
1udaUFGUDP-glucose 4-epimerase5.1.3.20.447
2tohHBITyrosine 3-monooxygenase1.14.16.20.447
3junAKDPhenazine biosynthesis protein A/B/0.447
4dfg0JVGag-Pol polyprotein3.4.23.160.447
1goxFMNPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.446
1rpnNDPGDP-mannose 4,6-dehydratase/0.446
1udcUFMUDP-glucose 4-epimerase5.1.3.20.446
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.446
2vbpVB1Isopenicillin N synthase1.21.3.10.446
2w6qOA5Biotin carboxylase6.3.4.140.446
2wi5ZZ5Heat shock protein HSP 90-alpha/0.446
2wo7ASVIsopenicillin N synthase1.21.3.10.446
3tzaTZGGlutamate receptor 2/0.446
4a83DXCMajor pollen allergen Bet v 1-A/0.446
4fevPP1Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.446
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.446
1e2nRCAThymidine kinase/0.445
1skmSAHModification methylase HhaI2.1.1.370.445
2f3rG5PGuanylate kinase2.7.4.80.445
2jb4A14Isopenicillin N synthase1.21.3.10.445
3fnlSHALactoperoxidase/0.445
3mx5UTPNucleoprotein/0.445
4e2bFMNDehydrogenase/0.445
4ipw1G7Mycocyclosin synthase1.14.21.90.445
3f3sNADLambda-crystallin homolog/0.444
3okfNAD3-dehydroquinate synthase4.2.3.40.444
4x81MVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.444
1db48INPhospholipase A2, membrane associated/0.443
1ow3GDPTransforming protein RhoA/0.443
2g9uG27Glycogen phosphorylase, muscle form2.4.1.10.443
3gstGPRGlutathione S-transferase Mu 12.5.1.180.443
3k4yIPEIsopentenyl phosphate kinase2.7.4.260.443
4j5rA1RO-acetyl-ADP-ribose deacetylase 13.5.10.443
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.443
4rjeFNRLactate oxidase/0.443
4xr9NADCalS8/0.443
1g93UPGN-acetyllactosaminide alpha-1,3-galactosyltransferase/0.442
1hb3SCVIsopenicillin N synthase1.21.3.10.442
1mraAPGMandelate racemase/0.442
1rd4L08Integrin alpha-L/0.442
2pamTYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.442
2vbdV10Isopenicillin N synthase1.21.3.10.442
2xkaGSPCell division protein FtsZ/0.442
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.442
3nl6TPSUncharacterized protein/0.442
4hy6FJ1Heat shock protein HSP 90-alpha/0.442
4ol0GTPGTP-binding nuclear protein Ran/0.442
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
1akcPPEAspartate aminotransferase, mitochondrial2.6.1.10.441
1hzjUD1UDP-glucose 4-epimerase/0.441
1j7lADPAminoglycoside 3'-phosphotransferase2.7.1.950.441
1vyrFMNPentaerythritol tetranitrate reductase/0.441
2yw2ATPPhosphoribosylamine--glycine ligase/0.441
2z1mNDPGDP-mannose 4,6-dehydratase/0.441
3buzLARActin, alpha skeletal muscle/0.441
3enkUPGUDP-glucose 4-epimerase/0.441
3o3jBB4Peptide deformylase 1B, chloroplastic/mitochondrial3.5.1.880.441
3t8wDGZM17 leucyl aminopeptidase/0.441
4ge1TSSBiogenic amine-binding protein/0.441
1d5cGDPGTPase (Rab6)/0.440
2anb5GPGuanylate kinase2.7.4.80.440
2nnqT4BFatty acid-binding protein, adipocyte/0.440
2pbzATPUncharacterized protein/0.440
2qa2FADPolyketide oxygenase CabE/0.440
2vwhNAPGlucose 1-dehydrogenase/0.440
2w6oOA3Biotin carboxylase6.3.4.140.440
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.440
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.440
3ujlA8SAbscisic acid receptor PYL2/0.440
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440