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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ofvFMNFlavodoxin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1ofvFMNFlavodoxin/1.000
1cznFMNFlavodoxin/0.872
2v5uFMNFlavodoxin/0.610
1c7fFMNFlavodoxin/0.601
3hr4FMNNitric oxide synthase, inducible1.14.13.390.586
3ojxFMNNADPH--cytochrome P450 reductase/0.582
1ahnFMNFlavodoxin 1/0.574
4y7cFMNNADPH--cytochrome P450 reductase/0.569
2fcrFMNFlavodoxin/0.568
3f6rFMNFlavodoxin/0.566
1j9gFMNFlavodoxin/0.564
1azlFMNFlavodoxin/0.542
1j9zFMNNADPH--cytochrome P450 reductase/0.542
5xraFMNCannabinoid receptor 1/0.541
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.526
1akuFMNFlavodoxin/0.525
1wsbFMNFlavodoxin/0.524
3busSAHDemethylrebeccamycin-D-glucose O-methyltransferase/0.524
1akwFMNFlavodoxin/0.523
1fx1FMNFlavodoxin/0.523
2mokFMNFlavodoxin 1/0.523
5tgzFMNCannabinoid receptor 1/0.521
1akrFMNFlavodoxin/0.518
1j8qFMNFlavodoxin/0.515
4nv0MG77-methylguanosine phosphate-specific 5'-nucleotidase/0.511
3esyFMNFlavodoxin/0.509
3f6sFMNFlavodoxin/0.509
2v5vFMNFlavodoxin/0.505
4h2dFMNNADPH-dependent diflavin oxidoreductase 1/0.504
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.504
3ojwFMNNADPH--cytochrome P450 reductase/0.502
1afeALZProthrombin3.4.21.50.501
1ja0FMNNADPH--cytochrome P450 reductase/0.498
1kruIPTGalactoside O-acetyltransferase2.3.1.180.498
5xr8FMNCannabinoid receptor 1/0.497
3qfrFMNNADPH--cytochrome P450 reductase/0.496
3kapFMNFlavodoxin/0.495
5fx2FMNFlavodoxin/0.495
2zwaSAHtRNA wybutosine-synthesizing protein 42.1.1.2900.494
3f90FMNFlavodoxin/0.494
4oxxFMNCindoxin/0.494
4fse0VABeta-secretase 13.4.23.460.493
2wu4HBPAcetylcholinesterase3.1.1.70.492
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.492
2piaFMNPhthalate dioxygenase reductase/0.491
1xyyFMNFlavodoxin/0.490
3ex8AIFRiboflavin biosynthesis protein RibD1.1.1.1930.490
4baqM4ZProthrombin3.4.21.50.490
4mubOAQSulfotransferase oxamniquine resistance protein/0.490
1ppl1Z7Penicillopepsin-13.4.23.200.489
2rc6FADFerredoxin--NADP reductase/0.489
1k21IGNProthrombin3.4.21.50.488
2vqbNAPPutative flavin-containing monooxygenase/0.488
3zc3FADFerredoxin--NADP reductase1.18.1.20.488
4oztP1AEcdysone receptor, putative/0.488
3udq09EBeta-secretase 13.4.23.460.487
1d9i00PProthrombin3.4.21.50.486
1e64FADFerredoxin--NADP reductase1.18.1.20.486
3h3qH13Collagen type IV alpha-3-binding protein/0.486
4fx2FMNFlavodoxin/0.486
3nsh957Beta-secretase 13.4.23.460.484
3qto10PProthrombin3.4.21.50.484
4i0i957Beta-secretase 13.4.23.460.484
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.484
2bn4FMNNADPH--cytochrome P450 reductase/0.483
3dv5BAVBeta-secretase 13.4.23.460.483
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.483
2r2mI50Prothrombin3.4.21.50.482
1dx6GNTAcetylcholinesterase3.1.1.70.481
2clmF6FTryptophan synthase alpha chain/0.481
2g226IGRenin3.4.23.150.481
3udn09BBeta-secretase 13.4.23.460.481
4b7zQ4QAcetylcholinesterase3.1.1.70.481
2zc922UProthrombin3.4.21.50.480
3zj7C1KStrictosidine-O-beta-D-glucosidase3.2.1.1050.480
5c3aURMHisto-blood group ABO system transferase/0.480
1e66HUXAcetylcholinesterase3.1.1.70.479
1fueFMNFlavodoxin/0.479
1ta6177Prothrombin3.4.21.50.479
3anlSYC1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.479
3rthRTHBeta-secretase 13.4.23.460.479
1qpl587Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.478
1w76GNTAcetylcholinesterase3.1.1.70.478
2a0yDIHPurine nucleoside phosphorylase2.4.2.10.478
2f2sCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.478
3ekuCY9Actin-5C/0.478
3kaqFMNFlavodoxin/0.478
4g1f0WGDipeptidyl peptidase 4/0.478
1bu5RBFFlavodoxin/0.477
1vzqSHYProthrombin3.4.21.50.477
1yobFMNFlavodoxin 2/0.477
2xufTZ4Acetylcholinesterase3.1.1.70.477
3gc4AAQQueuine tRNA-ribosyltransferase2.4.2.290.477
3p1799PProthrombin3.4.21.50.477
4az29MUProthrombin3.4.21.50.477
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
2cleF6FTryptophan synthase alpha chain/0.476
3qe2FMNNADPH--cytochrome P450 reductase/0.476
3qtv06PProthrombin3.4.21.50.476
3veu0GOBeta-secretase 13.4.23.460.476
2whqHI6Acetylcholinesterase3.1.1.70.475
3c36KAIGlutamate receptor ionotropic, kainate 1/0.475
3fhxPLPPyridoxal kinase2.7.1.350.475
3mteSAM16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.475
4c43FADFerredoxin--NADP reductase1.18.1.20.475
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.475
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.474
4yaoFMNNADPH--cytochrome P450 reductase/0.474
1owpFADDeoxyribodipyrimidine photo-lyase4.1.99.30.473
2a4xBLMMitomycin-binding protein/0.473
3c1kT15Prothrombin3.4.21.50.473
3h3r14HCollagen type IV alpha-3-binding protein/0.473
3oqfS51Renin3.4.23.150.473
4exg916Beta-secretase 13.4.23.460.473
4fsl0VBBeta-secretase 13.4.23.460.473
4twnB96Ephrin type-A receptor 32.7.10.10.473
1gjrFADFerredoxin--NADP reductase1.18.1.20.472
1kuxCA3Serotonin N-acetyltransferase/0.472
2g1y5IGRenin3.4.23.150.472
2znk31UProthrombin3.4.21.50.472
3uq9TBNPutative adenosine kinase/0.472
4bamMM9Prothrombin3.4.21.50.472
4da8BG2Purine nucleoside phosphorylase DeoD-type2.4.2.10.472
4qohSTLRibosyldihydronicotinamide dehydrogenase [quinone]/0.472
1h42FADFerredoxin--NADP reductase1.18.1.20.471
3udk095Beta-secretase 13.4.23.460.471
4banM6SProthrombin3.4.21.50.471
4n65FMNFMN-dependent NADH-azoreductase 1/0.471
1ae8AZLProthrombin3.4.21.50.470
1nzq162Prothrombin3.4.21.50.470
1s3vTQDDihydrofolate reductase1.5.1.30.470
2ikuLIYRenin3.4.23.150.470
2zi224UProthrombin3.4.21.50.470
3d91REMRenin3.4.23.150.470
3oqkS52Renin3.4.23.150.470
3zv7NHGAcetylcholinesterase3.1.1.70.470
4araC56Acetylcholinesterase3.1.1.70.470
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.470
1fdrFADFerredoxin--NADP reductase1.18.1.20.469
1gaqFADFerredoxin/0.469
1ve3SAMUncharacterized protein/0.469
3juqAJDPhenazine biosynthesis protein A/B/0.469
3vydVYDRenin3.4.23.150.469
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.469
4obwSAM2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial/0.469
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.468
1krv147Galactoside O-acetyltransferase2.3.1.180.468
1lvu9PPPurine nucleoside phosphorylase2.4.2.10.468
2i4qUA4Renin3.4.23.150.468
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.468
2qmyFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.468
2r8pT6FTransketolase 1/0.468
3junAJDPhenazine biosynthesis protein A/B/0.468
4bakM67Prothrombin3.4.21.50.468
4y3qF02Endothiapepsin3.4.23.220.468
3pblETQD(3) dopamine receptor/0.468
1bjkFADFerredoxin--NADP reductase1.18.1.20.467
1f3eDPZQueuine tRNA-ribosyltransferase2.4.2.290.467
1xs7MMIBeta-secretase 13.4.23.460.467
2iko7IGRenin3.4.23.150.467
2v00V15Endothiapepsin3.4.23.220.467
2xuhTZ4Acetylcholinesterase3.1.1.70.467
2zdv37UProthrombin3.4.21.50.467
3of3DIHPurine nucleoside phosphorylase DeoD-type 1/0.467
3qfsFADNADPH--cytochrome P450 reductase/0.467
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.466
2zfq45UProthrombin3.4.21.50.466
4d2dALA_ALA_ALADi-or tripeptide:H+ symporter/0.466
1d3dBZTProthrombin3.4.21.50.465
1jwtBLIProthrombin3.4.21.50.465
1vbiNADMalate/L-lactate dehydrogenase family protein/0.465
1w29TS06,7-dimethyl-8-ribityllumazine synthase2.5.1.780.465
1xqp8HGN-glycosylase/DNA lyase/0.465
3w5hFADNADH-cytochrome b5 reductase 31.6.2.20.465
4ax9N5NProthrombin3.4.21.50.465
4bfvZVVPantothenate kinase2.7.1.330.465
4isuIKMGlutamate receptor 2/0.465
1bxqPP8Penicillopepsin-13.4.23.200.464
1odcA8BAcetylcholinesterase3.1.1.70.464
1pq944BOxysterols receptor LXR-beta/0.464
1qrpHH0Pepsin A-43.4.23.10.464
2a9z26AAdenosine kinase2.7.1.200.464
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.464
2qmzLDPRibosyldihydronicotinamide dehydrogenase [quinone]/0.464
2v16C47Renin3.4.23.150.464
2w6cBM4Acetylcholinesterase3.1.1.70.464
3ohh3HHBeta-secretase 13.4.23.460.464
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.464
4mr72BVGamma-aminobutyric acid type B receptor subunit 1/0.464
1mvsDTMDihydrofolate reductase1.5.1.30.463
1pg0MODMethionine--tRNA ligase6.1.1.100.463
2gyuHI6Acetylcholinesterase3.1.1.70.463
3h0bB35Beta-secretase 13.4.23.460.463
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.463
3qt62P0Mevalonate diphosphate decarboxylase/0.463
3tzaTZGGlutamate receptor 2/0.463
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.463
3vsxR32Renin3.4.23.150.463
4a6aTTPdCTP deaminase3.5.4.130.463
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.463
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.463
4nwiCTN7-methylguanosine phosphate-specific 5'-nucleotidase/0.463
1g6oADPCag alpha/0.462
1p4aPCPPur operon repressor/0.462
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.462
1xagNAD3-dehydroquinate synthase/0.462
2f3eAXQBeta-secretase 13.4.23.460.462
2g1n1IGRenin3.4.23.150.462
2g274LGRenin3.4.23.150.462
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.462
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.462
4wdfA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.462
1fw0KAIGlutamate receptor 2/0.461
1kw0H4BPhenylalanine-4-hydroxylase1.14.16.10.461
1u1gBBBUridine phosphorylase2.4.2.30.461
2wedPP6Penicillopepsin-13.4.23.200.461
2wf3ZY3Beta-secretase 13.4.23.460.461
2zg050UProthrombin3.4.21.50.461
3aosJH2Hemolymph juvenile hormone binding protein/0.461
3c35KAIGlutamate receptor ionotropic, kainate 1/0.461
3qbhQBHBeta-secretase 13.4.23.460.461
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.461
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.461
4rvgTYDD-mycarose 3-C-methyltransferase/0.461
4ytnFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.461
1e81M91Endothiapepsin3.4.23.220.460
1f20FADNitric oxide synthase, brain1.14.13.390.460
1k9sFM1Purine nucleoside phosphorylase DeoD-type/0.460
1nbiSAMGlycine N-methyltransferase2.1.1.200.460
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.460
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.460
2w6pOA4Biotin carboxylase6.3.4.140.460
3g5mFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.460
3nhfVVVRibosyldihydronicotinamide dehydrogenase [quinone]/0.460
3o6o94MHeat shock protein 83/0.460
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.460
4k9h1QUBeta-secretase 13.4.23.460.460
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.460
1nm6L86Prothrombin3.4.21.50.459
1rkwPNTHTH-type transcriptional regulator QacR/0.459
1rneC60Renin3.4.23.150.459
2cv1ATPGlutamate--tRNA ligase6.1.1.170.459
2xvhNAPPutative flavin-containing monooxygenase/0.459
3h3t16HCollagen type IV alpha-3-binding protein/0.459
3krfIPEGeranyl diphosphate synthase large subunit/0.459
4qoeFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.459
1oc1ASVIsopenicillin N synthase1.21.3.10.458
1wopFFOAminomethyltransferase/0.458
1x8lOXRRetinol dehydratase/0.458
2bxtC2DProthrombin3.4.21.50.458
2g247IGRenin3.4.23.150.458
2il2LIXRenin3.4.23.150.458
2webPP4Penicillopepsin-13.4.23.200.458
3bgsDIHPurine nucleoside phosphorylase2.4.2.10.458
3bw2FMNPutative 2-nitropropane dioxygenase/0.458
3klbFMNUncharacterized protein/0.458
3ndjJHZMethyltransferase/0.458
3q43D66M1 family aminopeptidase3.4.110.458
3qfcFADNADPH--cytochrome P450 reductase/0.458
4dbw511Aldo-keto reductase family 1 member C3/0.458
4iilRBFMembrane lipoprotein TpN38(b)/0.458
4j0t6T9Beta-secretase 13.4.23.460.458
4lxb7R9Prothrombin3.4.21.50.458
1bduDURThymidylate synthase/0.457
1h22E10Acetylcholinesterase3.1.1.70.457
1qtiGNTAcetylcholinesterase3.1.1.70.457
1w6rGNTAcetylcholinesterase3.1.1.70.457
1yw9A84Methionine aminopeptidase 2/0.457
2b01TUDPhospholipase A2, major isoenzyme3.1.1.40.457
2jh5895Prothrombin3.4.21.50.457
2qs4LY5Glutamate receptor ionotropic, kainate 1/0.457
3k5c0BIBeta-secretase 13.4.23.460.457
5a4vQUEGlutathione S-transferase F22.5.1.180.457
5icfSAH(S)-norcoclaurine 6-O-methyltransferase/0.457
4u140HKMuscarinic acetylcholine receptor M3/0.457
1fvpFMANon-fluorescent flavoprotein/0.456
1gvv0GMEndothiapepsin3.4.23.220.456
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.456
2bf4FADNADPH--cytochrome P450 reductase/0.456
3ai0PNWBeta-glucosidase/0.456
3n39FMNProtein NrdI/0.456
3t6iNC8Endothiapepsin3.4.23.220.456
3t7x4SHEndothiapepsin3.4.23.220.456
4frkDWDBeta-secretase 13.4.23.460.456
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.456
4j0v1H7Beta-secretase 13.4.23.460.456
4n9qFMNFMN-dependent NADH-azoreductase 1/0.456
4qofFMNRibosyldihydronicotinamide dehydrogenase [quinone]/0.456
5ctoNTD4-hydroxyphenylpyruvate dioxygenase1.13.11.270.456
1dljUGAUDP-glucose 6-dehydrogenase/0.455
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.455
1sm4FADFerredoxin--NADP reductase/0.455
1swpBTQStreptavidin/0.455
1xyvFMNFlavodoxin/0.455
2bvs2CEProthrombin3.4.21.50.455
2g263LGRenin3.4.23.150.455
2vr0HQOCytochrome c-type protein/0.455
3biu10UProthrombin3.4.21.50.455
3n3aFMNProtein NrdI/0.455
3udj092Beta-secretase 13.4.23.460.455
3wqtANPCell division protein FtsA/0.455
4baoMVFProthrombin3.4.21.50.455
4bis8HQLysine-specific demethylase 4A1.14.110.455
4qzuRTLRetinol-binding protein 2/0.455
7kmeACE_0BN_CHG_PRRProthrombin3.4.21.50.455
1bim0QBRenin3.4.23.150.454
1me6IVSPlasmepsin-23.4.23.390.454
2aovC2MHistamine N-methyltransferase2.1.1.80.454
2ejzSAHDiphthine synthase/0.454
2iyaZIOOleandomycin glycosyltransferase/0.454
2ok8FADFerredoxin--NADP reductase, apicoplast/0.454
2xuoTZ4Acetylcholinesterase3.1.1.70.454
3ix8TX3Transcriptional activator protein LasR/0.454
3p2kSAM16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.454
3pwwROCEndothiapepsin3.4.23.220.454
3uxvGUNNADPH-dependent 7-cyano-7-deazaguanine reductase/0.454
4bb3KKAIsopenicillin N synthase1.21.3.10.454
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.454
4c717RD3-oxoacyl-ACP synthase/0.454
4du6GTPGTP cyclohydrolase 1/0.454
4e7r0NWProthrombin3.4.21.50.454
4ey6GNTAcetylcholinesterase3.1.1.70.454
4g95OAGDihydrofolate reductase1.5.1.30.454
5d4uSAMUncharacterized protein MJ0489/0.454
1u65CP0Acetylcholinesterase3.1.1.70.453
2pb1NFGGlucan 1,3-beta-glucosidase/0.453
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.453
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.453
2wjoQUDBeta-secretase 13.4.23.460.453
2yeiXQIHeat shock protein HSP 90-alpha/0.453
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.453
3bw4FMNPutative 2-nitropropane dioxygenase/0.453
3r2fPB0Beta-secretase 13.4.23.460.453
3rsv3RSBeta-secretase 13.4.23.460.453
3u8n09SAcetylcholine-binding protein/0.453
4bfxZVXPantothenate kinase2.7.1.330.453
4dxlC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.453
4s1iPLPPyridoxal kinase, putative/0.453
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.453
1ib1COTSerotonin N-acetyltransferase/0.452
1k9sFM2Purine nucleoside phosphorylase DeoD-type/0.452
1n08ADPRiboflavin kinase2.7.1.260.452
1w1vALJChitinase/0.452
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.452
2cjpVPREpoxide hydrolase/0.452
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.452
2ph6712Beta-secretase 13.4.23.460.452
3bl7DD1m7GpppX diphosphatase3.6.1.590.452
3ce0P34Poly [ADP-ribose] polymerase 32.4.2.300.452
3ix4TX1Transcriptional activator protein LasR/0.452
3lkhLT6Genome polyprotein2.7.7.480.452
3wquATPCell division protein FtsA/0.452
4a86H35Major pollen allergen Bet v 1-A/0.452
4arbC57Acetylcholinesterase3.1.1.70.452
4at0FADPossible succinate dehydrogenase/0.452
4bftZVTPantothenate kinase2.7.1.330.452
4ts7ADPPurine phosphoribosyltransferase (GpT-1)/0.452
1dduDDUThymidylate synthase/0.451
1k22MELProthrombin3.4.21.50.451
1od10QSEndothiapepsin3.4.23.220.451
1ppkIVVPenicillopepsin-13.4.23.200.451
2a2dANPN-acetylgalactosamine kinase2.7.1.1570.451
2bpoFADNADPH--cytochrome P450 reductase/0.451
2vq7NAPPutative flavin-containing monooxygenase/0.451
2wecPP5Penicillopepsin-13.4.23.200.451
2xluNA7Putative flavin-containing monooxygenase/0.451
3duyAFJBeta-secretase 13.4.23.460.451
3pmy41LEndothiapepsin3.4.23.220.451
4e32DWNMethyltransferase/0.451
4eilUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.451
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.451
4k88HFGBifunctional glutamate/proline--tRNA ligase6.1.1.150.451
4ts9FMCPurine nucleoside phosphorylase DeoD-type/0.451
5cmx0G6Prothrombin3.4.21.50.451
1hb3SCVIsopenicillin N synthase1.21.3.10.450
1ja0NAPNADPH--cytochrome P450 reductase/0.450
1kkq471Peroxisome proliferator-activated receptor alpha/0.450
1knpFADL-aspartate oxidase1.4.3.160.450
1nmq160Caspase-33.4.22.560.450
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.450
1ypmRA4Prothrombin3.4.21.50.450
1zgcA2EAcetylcholinesterase3.1.1.70.450
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.450
2ha6SCKAcetylcholinesterase3.1.1.70.450
2v3hI25Prothrombin3.4.21.50.450
2vetUMPThymidylate synthase/0.450
2xugTZ4Acetylcholinesterase3.1.1.70.450
2y60M8FIsopenicillin N synthase1.21.3.10.450
2zhw12UProthrombin3.4.21.50.450
3fsjD7KBenzoylformate decarboxylase4.1.1.70.450
3ihgVAKAklavinone 12-hydroxylase RdmE/0.450
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.450
3kmxG00Beta-secretase 13.4.23.460.450
3kn03TOBeta-secretase 13.4.23.460.450
3l7gM44Xaa-Pro dipeptidase3.4.13.90.450
3nn6HNK6-hydroxy-L-nicotine oxidase/0.450
3rdqDTBStreptavidin/0.450
3v0o4GWHisto-blood group ABO system transferase/0.450
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.450
3zovWZVBeta-secretase 13.4.23.460.450
4bfwZVWPantothenate kinase2.7.1.330.450
4bprFADFerredoxin--NADP reductase1.18.1.20.450
4id9NADPutative UDP-glucose 4-epimerase/0.450
5bv3M7Gm7GpppX diphosphatase3.6.1.590.450
5choFADFlavin reductase/0.450
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.449
1c7oPPGHemolysin/0.449
1h66RH1NAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1j8uH4BPhenylalanine-4-hydroxylase1.14.16.10.449
1v453DGPurine nucleoside phosphorylase2.4.2.10.449
1w87FADFerredoxin--NADP reductase1.18.1.20.449
2cmfF11Acetylcholinesterase3.1.1.70.449
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.449
2pncCLUPrimary amine oxidase, liver isozyme/0.449
2qzlIXSBeta-secretase 13.4.23.460.449
2weaPP6Penicillopepsin-13.4.23.200.449
3apwDP0Alpha-1-acid glycoprotein 2/0.449
3junAKDPhenazine biosynthesis protein A/B/0.449
3vyeVYERenin3.4.23.150.449
3vyfVYFRenin3.4.23.150.449
4bvhOCZNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.449
4dldTZGGlutamate receptor ionotropic, kainate 1/0.449
4y3zF41Endothiapepsin3.4.23.220.449
5ah5LSSLeucine--tRNA ligase/0.449
3sn6P0GBeta-2 adrenergic receptor/0.449
1eveE20Acetylcholinesterase3.1.1.70.448
2xlpNAPPutative flavin-containing monooxygenase/0.448
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3eq02TSProthrombin3.4.21.50.448
3gwdFADCyclohexanone monooxygenase/0.448
3p67FMNPentaerythritol tetranitrate reductase/0.448
3qwc98PProthrombin3.4.21.50.448
3tifADPUncharacterized ABC transporter ATP-binding protein MJ0796/0.448
3vilSA0Beta-glucosidase/0.448
3vo2FADFerredoxin--NADP reductase/0.448
3wthIM4Acetylcholine-binding protein/0.448
4a802ANMajor pollen allergen Bet v 1-A/0.448
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.448
4awsFMNNADH:flavin oxidoreductase Sye1/0.448
4f1yCNIGlutamate receptor 3/0.448
4iraFAD4-hydroxyphenylacetate 3-monooxygenase/0.448
4rn615UProthrombin3.4.21.50.448
4uy6SAHHistidine N-alpha-methyltransferase/0.448
5p2pDHGPhospholipase A2, major isoenzyme3.1.1.40.448
4gbrCAUBeta-2 adrenergic receptor/0.448
1e62FADFerredoxin--NADP reductase1.18.1.20.447
1ix1BB2Peptide deformylase/0.447
1lb9DNQGlutamate receptor 2/0.447
1pj6FOLDimethylglycine oxidase1.5.3.100.447
1pwyAC2Purine nucleoside phosphorylase2.4.2.10.447
1r5gAO1Methionine aminopeptidase 2/0.447
1s3uTQDDihydrofolate reductase1.5.1.30.447
1w7h3IPMitogen-activated protein kinase 14/0.447
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.447
2avxHTFRegulatory protein SdiA/0.447
2cv2GSUGlutamate--tRNA ligase6.1.1.170.447
2j62GSZO-GlcNAcase NagJ/0.447
2v34CTN4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.447
2wf2ZY2Beta-secretase 13.4.23.460.447
2xi4AFTAcetylcholinesterase3.1.1.70.447
3ensENSCoagulation factor X3.4.21.60.447
3ho2N323-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.447
3own3OWRenin3.4.23.150.447
3qgf46FGenome polyprotein2.7.7.480.447
3t7qRB4Endothiapepsin3.4.23.220.447
3wtkTH4Acetylcholine-binding protein/0.447
4mk828QGenome polyprotein2.7.7.480.447
4yaoFADNADPH--cytochrome P450 reductase/0.447
4yau2AMNADPH--cytochrome P450 reductase/0.447
5agyGTBTau class glutathione S-transferase/0.447
3uonQNBMuscarinic acetylcholine receptor M2/0.447
1ycgFMNNitric oxide reductase10.446
2cftPLPPyridoxal phosphate phosphatase/0.446
2pksG44Prothrombin3.4.21.50.446
2zr9DTPProtein RecA/0.446
3cobADPKinesin heavy chain-like protein/0.446
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.446
3hyg099A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.446
3kozZ97D-ornithine 4,5-aminomutase subunit beta/0.446
3pn1IVHDNA ligase/0.446
3skgPB8Beta-secretase 13.4.23.460.446
4b63NAPL-ornithine N(5)-monooxygenase/0.446
4b68NAPL-ornithine N(5)-monooxygenase/0.446
4eb7PLPCysteine desulfurase IscS 2/0.446
4hmz18TdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.446
4j1e1HMBeta-secretase 13.4.23.460.446
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.446
1c4yIH3Prothrombin3.4.21.50.445
1eirBPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.445
1kw8BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.445
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.445
1swtBTNStreptavidin/0.445
1votHUPAcetylcholinesterase3.1.1.70.445
1xzqFONtRNA modification GTPase MnmE3.6.50.445
1yqzCOACoenzyme A disulfide reductase/0.445
1zx1CB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.445
2a9y26AAdenosine kinase2.7.1.200.445
2anmCDOProthrombin3.4.21.50.445
2bktRPFRenin3.4.23.150.445
2geuCOKPantothenate kinase2.7.1.330.445
2j0sANPEukaryotic initiation factor 4A-III3.6.4.130.445
2nm2NEUDihydroneopterin aldolase/0.445
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.445
2oazI96Methionine aminopeptidase 2/0.445
2wn6NDPADP-ribosyltransferase enzymatic component/0.445
2y882ERPhosphoribosyl isomerase A5.3.1.160.445
3b7dCNIGlutamate receptor 2/0.445
3ixk929Beta-secretase 13.4.23.460.445
3psyRB9Endothiapepsin3.4.23.220.445
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.445
4azmT4BFatty acid-binding protein, epidermal/0.445
4rrrA3TThreonine--tRNA ligase6.1.1.30.445
4to1DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.445
1aqv0HGGlutathione S-transferase P2.5.1.180.444
1gvt2ZSEndothiapepsin3.4.23.220.444
1hvyD16Thymidylate synthase2.1.1.450.444
1lv89PPPurine nucleoside phosphorylase2.4.2.10.444
1pqc444Oxysterols receptor LXR-beta/0.444
2a2cADPN-acetylgalactosamine kinase2.7.1.1570.444
2bdyUNBProthrombin3.4.21.50.444
2bzsCB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.444
2dpmSAMModification methylase DpnIIA2.1.1.720.444
2g8yNADHydroxycarboxylate dehydrogenase B/0.444
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.444
2pbzATPUncharacterized protein/0.444
2rc5FADFerredoxin--NADP reductase/0.444
2vrjNCWBeta-glucosidase A3.2.1.210.444
2zfp19UProthrombin3.4.21.50.444
3b5iSAHIndole-3-acetate O-methyltransferase 1/0.444
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.444
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.444
3ho9N3A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.444
3q7jFBOTricorn protease-interacting factor F33.4.110.444
3qbwADPAnhydro-N-acetylmuramic acid kinase/0.444
3uptTPPTransketolase/0.444
3vswR31Renin3.4.23.150.444
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.444
4bj9UHBTankyrase-22.4.2.300.444
4bz7B3NHistone deacetylase/0.444
4e2yJHZMethyltransferase/0.444
5ig2NADShort-chain dehydrogenase/reductase SDR/0.444
5d5bCAUBeta-2 adrenergic receptor/0.444
1d3pBT3Prothrombin3.4.21.50.443
1gawFADFerredoxin/0.443
1j9zFADNADPH--cytochrome P450 reductase/0.443
1ja1FADNADPH--cytochrome P450 reductase/0.443
1jdvADNPurine nucleoside phosphorylase/0.443
1jtuLYBThymidylate synthase/0.443
1nhkCMPNucleoside diphosphate kinase2.7.4.60.443
1qh0FADFerredoxin--NADP reductase1.18.1.20.443
1wooTHGAminomethyltransferase/0.443
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.443
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.443
2fs4PZ1Renin3.4.23.150.443
2g94ZPQBeta-secretase 13.4.23.460.443
2iqgF2IBeta-secretase 13.4.23.460.443
2jji0QSEndothiapepsin3.4.23.220.443
2ntrL00Beta-secretase 13.4.23.460.443
2oc4IMHPurine nucleoside phosphorylase2.4.2.10.443
2vt4P32Beta-1 adrenergic receptor/0.443
2ztsADPUncharacterized protein/0.443
3eszFMNFlavodoxin/0.443
3gwfFADCyclohexanone monooxygenase/0.443
3i6qNDPPutative leucoanthocyanidin reductase 1/0.443
3ojxFADNADPH--cytochrome P450 reductase/0.443
3qviK95HAP protein/0.443
3rtnRTNBeta-secretase 13.4.23.460.443
4fs4H24Beta-secretase 13.4.23.460.443
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
4ieiADPGene 2 protein/0.443
4iwnGEKCarboxy-S-adenosyl-L-methionine synthase/0.443
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.443
1amoFADNADPH--cytochrome P450 reductase/0.442
1jqdSAHHistamine N-methyltransferase2.1.1.80.442
1k7fIAVTryptophan synthase alpha chain/0.442
1ndzFR5Adenosine deaminase3.5.4.40.442
1ogiFADFerredoxin--NADP reductase1.18.1.20.442
1rfgGMPPurine nucleoside phosphorylase2.4.2.10.442
1tllFADNitric oxide synthase, brain1.14.13.390.442
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.442
1w19T1P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
1w19T5P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
1xmmM7Gm7GpppX diphosphatase3.6.1.590.442
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.442
1ypeUIPProthrombin3.4.21.50.442
1zgv501Prothrombin3.4.21.50.442
2fdpFRPBeta-secretase 13.4.23.460.442
2g1o2IGRenin3.4.23.150.442
2i62SAHNicotinamide N-methyltransferase2.1.1.10.442
2jh6894Prothrombin3.4.21.50.442
2rlcCHDCholoylglycine hydrolase3.5.1.240.442
2wwjY28Lysine-specific demethylase 4A/0.442
2zgx29UProthrombin3.4.21.50.442
3g70A5TRenin3.4.23.150.442
3v0p4GWHisto-blood group ABO system transferase/0.442
3wagTYDGlycosyltransferase/0.442
4f0e0RUPoly [ADP-ribose] polymerase 152.4.2.300.442
4j0z1H5Beta-secretase 13.4.23.460.442
4j1k1HGBeta-secretase 13.4.23.460.442
4jlm1NNDeoxycytidine kinase2.7.1.740.442
4jtrIZPAldo-keto reductase family 1 member C2/0.442
4rtjSFGDNA adenine methylase2.1.1.720.442
1db48INPhospholipase A2, membrane associated/0.441
1e82M90Endothiapepsin3.4.23.220.441
1gaxVAAValine--tRNA ligase6.1.1.90.441
1ivsVAAValine--tRNA ligase6.1.1.90.441
1ja0FADNADPH--cytochrome P450 reductase/0.441
1qk35GPHypoxanthine-guanine-xanthine phosphoribosyltransferase2.4.2.220.441
1qvtPRLHTH-type transcriptional regulator QacR/0.441
1rvvINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
1thz326Bifunctional purine biosynthesis protein PURH2.1.2.30.441
1vf2GTXGlutathione S-transferase 32.5.1.180.441
1zgi382Prothrombin3.4.21.50.441
2ckmAA7Acetylcholinesterase3.1.1.70.441
2dxiATPGlutamate--tRNA ligase6.1.1.170.441
2hp2KE4Glutamate-1-semialdehyde 2,1-aminomutase5.4.3.80.441
2p83MR0Beta-secretase 13.4.23.460.441
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.441
2v3oI26Prothrombin3.4.21.50.441
2zff53UProthrombin3.4.21.50.441
3b4p3B4Phenazine biosynthesis protein A/B/0.441
3cow52HPantothenate synthetase6.3.2.10.441
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3irhDTPHD domain protein/0.441
3k5dXLIBeta-secretase 13.4.23.460.441
3occDIHPurine nucleoside phosphorylase DeoD-type/0.441
3tpr5HABeta-secretase 13.4.23.460.441
3vqsJT1Genome polyprotein/0.441
3w5uFADFerredoxin/0.441
4ao4PLKBeta-transaminase/0.441
4c49HCYCorticosteroid-binding globulin/0.441
4dbs0HVAldo-keto reductase family 1 member C3/0.441
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.441
4k5o1OTM1 family aminopeptidase3.4.110.441
4mv8ACPBiotin carboxylase6.3.4.140.441
4uugPXGBranched-chain amino acid aminotransferase, putative/0.441
4wx2F6FTryptophan synthase alpha chain/0.441
4wx2F6FTryptophan synthase beta chain4.2.1.200.441
5dstSAHProtein arginine N-methyltransferase 82.1.10.441
1gvhFADFlavohemoprotein/0.440
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1ihiIU5Aldo-keto reductase family 1 member C2/0.440
1mueCDDProthrombin3.4.21.50.440
1qu2MRCIsoleucine--tRNA ligase6.1.1.50.440
1queFADFerredoxin--NADP reductase1.18.1.20.440
1r2jFADFkbI/0.440
1ry0PG2Aldo-keto reductase family 1 member C3/0.440
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.440
1z6tADPApoptotic protease-activating factor 1/0.440
2g21L1BRenin3.4.23.150.440
2onfCOAUncharacterized protein/0.440
2qs1UB1Glutamate receptor ionotropic, kainate 1/0.440
2vteIK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
2wf1ZY1Beta-secretase 13.4.23.460.440
2yp0OVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.440
2zhq27UProthrombin3.4.21.50.440
3c34KAIGlutamate receptor ionotropic, kainate 1/0.440
3djjFADGlutathione reductase, mitochondrial1.8.1.70.440
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.440
3exo5MSBeta-secretase 13.4.23.460.440
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.440
3ju8NADN-succinylglutamate 5-semialdehyde dehydrogenase1.2.1.710.440
3ohf3HFBeta-secretase 13.4.23.460.440
3rykTYDdTDP-4-dehydrorhamnose 3,5-epimerase/0.440
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.440
4azy7F3Beta-secretase 13.4.23.460.440
4bahMELProthrombin3.4.21.50.440
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.440
4h3j10WBeta-secretase 13.4.23.460.440
4jtqFLPAldo-keto reductase family 1 member C2/0.440
4l17DNQGlutamate receptor 2/0.440
4l8u9AZSerum albumin/0.440
4lfgIPEPutative geranyltranstransferase/0.440
4nieNBHNuclear receptor ROR-gamma/0.440
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.440
4r5wXAVPoly [ADP-ribose] polymerase 12.4.2.300.440
4zzjCNANAD-dependent protein deacetylase sirtuin-13.5.10.440