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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1o1t2NHProtein farnesyltransferase subunit beta2.5.1.58

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1o1t2NHProtein farnesyltransferase subunit beta2.5.1.581.000
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.801
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.684
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.634
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.631
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.627
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.625
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.625
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.614
2f0y3MNProtein farnesyltransferase subunit beta2.5.1.580.610
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.607
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.602
3sfy3FYUncharacterized protein/0.602
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.601
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.600
1s63778Protein farnesyltransferase subunit beta2.5.1.580.593
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.584
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.583
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.581
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.573
3q7fED2Uncharacterized protein/0.568
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.503
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.461
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.445
3g70A5TRenin3.4.23.150.443