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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ny3ADPMAP kinase-activated protein kinase 22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ny3ADPMAP kinase-activated protein kinase 22.7.11.11.000
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.558
4l9i8PRRhodopsin kinase/0.558
3c4xATPRhodopsin kinase/0.551
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.544
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.538
3c4wATPRhodopsin kinase/0.536
3t8oATPRhodopsin kinase/0.534
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.530
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.524
2ijmATPFocal adhesion kinase 12.7.10.20.518
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.518
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.514
4j95ACPFibroblast growth factor receptor 2/0.513
2w1fL0FAurora kinase A2.7.11.10.510
3i60E86Mitogen-activated protein kinase 12.7.11.240.510
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.509
4ic7ANPMitogen-activated protein kinase 72.7.11.240.508
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.508
3c4zADPRhodopsin kinase/0.507
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.507
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.505
3a62STURibosomal protein S6 kinase beta-12.7.11.10.503
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.502
3qc9ADPRhodopsin kinase/0.502
2j0lANPFocal adhesion kinase 12.7.10.20.501
3igoANPCalmodulin-domain protein kinase 1, putative/0.501
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.500
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.500
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.495
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.495
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.494
4qmlANPSerine/threonine-protein kinase 242.7.11.10.494
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.493
3sheI85MAP kinase-activated protein kinase 32.7.11.10.492
4c3pACPAurora kinase A2.7.11.10.492
2uzbC75Cyclin-dependent kinase 22.7.11.220.491
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.491
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.491
4dt9GMPAPH(2'')-Id/0.490
2ijmADPFocal adhesion kinase 12.7.10.20.487
2ojj82AMitogen-activated protein kinase 12.7.11.240.487
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.487
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.485
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.485
4eooATPCyclin-dependent kinase 22.7.11.220.484
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.484
4jia1K3Tyrosine-protein kinase JAK2/0.484
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.484
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.484
4ysjADPCalmodulin-like domain protein kinase/0.484
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.483
4j99ACPFibroblast growth factor receptor 2/0.483
2uzdC85Cyclin-dependent kinase 22.7.11.220.482
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.482
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.482
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.481
4aguD15Cyclin-dependent kinase-like 1/0.481
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.481
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.481
1i44ACPInsulin receptor2.7.10.10.479
2j0m4STFocal adhesion kinase 12.7.10.20.479
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.479
4o0wADNAurora kinase A2.7.11.10.479
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
3dfcANPDeath-associated protein kinase 12.7.11.10.478
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.478
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.478
2ozoANPTyrosine-protein kinase ZAP-702.7.10.20.477
2vv9IM9Cyclin-dependent kinase 22.7.11.220.477
3c50ADPRhodopsin kinase/0.477
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.477
4btjADPTau-tubulin kinase 12.7.11.10.477
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.476
3zh8C58Protein kinase C iota type2.7.11.130.476
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.475
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.475
5dnrATPAurora kinase A2.7.11.10.475
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.473
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.473
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.473
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.473
4fv6E57Mitogen-activated protein kinase 12.7.11.240.473
4jqeANPCasein kinase II subunit alpha2.7.11.10.473
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.472
2cchATPCyclin-dependent kinase 22.7.11.220.471
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.471
3lltANPProtein serine/threonine kinase-1/0.471
4ix5ANPUncharacterized protein/0.471
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.471
4o0uADNAurora kinase A2.7.11.10.471
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.470
2hog710Serine/threonine-protein kinase Chk12.7.11.10.470
2x1nX1NCyclin-dependent kinase 22.7.11.220.469
4deeADPAurora kinase A2.7.11.10.469
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.469
5av2KMPDeath-associated protein kinase 12.7.11.10.469
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.468
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.468
4eor4SPCyclin-dependent kinase 22.7.11.220.468
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.468
3pxkPXKFocal adhesion kinase 12.7.10.20.467
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.467
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.467
5e8ySTUTGF-beta receptor type-22.7.11.300.467
2xngA0HAurora kinase A2.7.11.10.466
3my5RFZCyclin-dependent kinase 22.7.11.220.466
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.466
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.466
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.465
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.465
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.465
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
4fod0UVALK tyrosine kinase receptor2.7.10.10.465
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.465
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.464
3kvxFMYMitogen-activated protein kinase 102.7.11.240.464
3ormAGSSerine/threonine protein kinase/0.464
4y93746Tyrosine-protein kinase/0.464
4y95746Tyrosine-protein kinase/0.464
3hmm855TGF-beta receptor type-12.7.11.300.463
3nieANPMitogen-activated protein kinase/0.463
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.463
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.462
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.462
3a8wATPProtein kinase C iota type2.7.11.130.462
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.462
4dtaADNAPH(2'')-Id/0.462
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.462
4ix6ADPUncharacterized protein/0.462
1p4fDRGDeath-associated protein kinase 12.7.11.10.461
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.461
2r3iSCFCyclin-dependent kinase 22.7.11.220.461
3r7yZ04Cyclin-dependent kinase 22.7.11.220.461
1zrzBI1Protein kinase C iota type2.7.11.130.460
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.460
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.460
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4k33ACPFibroblast growth factor receptor 32.7.10.10.460
5cnnANPEpidermal growth factor receptor2.7.10.10.460
2pwlACPFibroblast growth factor receptor 2/0.459
2qoqANPEphrin type-A receptor 32.7.10.10.459
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.459
4bcmT7ZCyclin-dependent kinase 22.7.11.220.459
4qnyANPMitogen activated protein kinase, putative/0.459
5cnoANPEpidermal growth factor receptor2.7.10.10.459
1fvv107Cyclin-dependent kinase 22.7.11.220.458
2c6iDT1Cyclin-dependent kinase 22.7.11.220.458
2v7a627Tyrosine-protein kinase ABL12.7.10.20.458
3a7hATPSerine/threonine-protein kinase 242.7.11.10.458
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.458
4b99R4LMitogen-activated protein kinase 72.7.11.240.458
4lrjANPUncharacterized protein/0.458
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.458
5dosATPAurora kinase A2.7.11.10.458
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.457
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.457
3s2pPMUCyclin-dependent kinase 22.7.11.220.457
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.456
2pvmP29Casein kinase II subunit alpha2.7.11.10.456
3r73X87Cyclin-dependent kinase 22.7.11.220.456
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.455
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.455
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.455
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.455
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.455
4fob0USALK tyrosine kinase receptor2.7.10.10.455
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.455
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.455
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.455
1g5sI17Cyclin-dependent kinase 22.7.11.220.454
1h0w207Cyclin-dependent kinase 22.7.11.220.454
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.454
2w05FRTCyclin-dependent kinase 22.7.11.220.454
3orpAGSSerine/threonine protein kinase/0.454
4gk2L66Ephrin type-A receptor 32.7.10.10.454
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.454
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.453
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.453
2c6lDT4Cyclin-dependent kinase 22.7.11.220.453
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.453
2yaaATPDeath-associated protein kinase 2/0.453
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.453
3zewSTUEphrin type-B receptor 42.7.10.10.453
4btjATPTau-tubulin kinase 12.7.11.10.453
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.452
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.452
3gubGUBDeath-associated protein kinase 12.7.11.10.452
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.452
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.451
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.451
2w17I19Cyclin-dependent kinase 22.7.11.220.451
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.451
2xvdAS6Ephrin type-B receptor 42.7.10.10.451
3ncz3NCRho-associated protein kinase 12.7.11.10.451
4fuxE75Mitogen-activated protein kinase 12.7.11.240.451
4gk3L87Ephrin type-A receptor 32.7.10.10.451
4jboWPHAurora kinase A2.7.11.10.451
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.450
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.450
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.450
2izsBRQCasein kinase I isoform gamma-32.7.11.10.450
2vu3LZECyclin-dependent kinase 22.7.11.220.450
2wqeADPAurora kinase A2.7.11.10.450
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.450
3hkoANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands/0.450
3nynSGVG protein-coupled receptor kinase 62.7.11.160.450
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.450
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.450
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.450
5ap7SVEDual specificity protein kinase TTK2.7.12.10.450
2yn8STUEphrin type-B receptor 42.7.10.10.449
3k5uPFQAurora kinase A2.7.11.10.449
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.449
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.449
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.449
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.449
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.449
4zseANPEpidermal growth factor receptor2.7.10.10.449
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.448
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.448
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.448
2vd5BI8Myotonin-protein kinase2.7.11.10.448
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.448
4k2rANPTyrosine-protein kinase ZAP-702.7.10.20.448
4qo9627Serine/threonine-protein kinase 242.7.11.10.448
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.447
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.447
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.447
3gu7ADPDeath-associated protein kinase 12.7.11.10.447
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.447
1pmn984Mitogen-activated protein kinase 102.7.11.240.446
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.446
2xrwANPMitogen-activated protein kinase 82.7.11.240.446
4im2BX7Serine/threonine-protein kinase TBK12.7.11.10.446
5l8lADPAurora kinase A2.7.11.10.446
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.445
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.445
1unlRRCCyclin-dependent-like kinase 52.7.11.10.445
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.445
2xp2VGHALK tyrosine kinase receptor2.7.10.10.445
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.445
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.445
1e3eNAIAlcohol dehydrogenase 41.1.1.10.444
1u54ACPActivated CDC42 kinase 1/0.444
2acxANPG protein-coupled receptor kinase 62.7.11.160.444
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.444
2b53D23Cyclin-dependent kinase 22.7.11.220.444
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.444
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.444
4foc0UUALK tyrosine kinase receptor2.7.10.10.444
4ji91M3Tyrosine-protein kinase JAK2/0.444
1eh4IC1Casein kinase I homolog 12.7.11.10.443
1eioGCHGastrotropin/0.443
1oitHDTCyclin-dependent kinase 22.7.11.220.443
1pyePM1Cyclin-dependent kinase 22.7.11.220.443
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.443
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2xs0ANPMitogen-activated protein kinase 82.7.11.240.443
2zjwREFCasein kinase II subunit alpha2.7.11.10.443
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.442
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.442
2henADPEphrin type-B receptor 22.7.10.10.442
3vpcADPGlutamate--LysW ligase ArgX6.3.20.442
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
5av3KMPDeath-associated protein kinase 12.7.11.10.442
1aq1STUCyclin-dependent kinase 22.7.11.220.441
1pkdUCNCyclin-dependent kinase 22.7.11.220.441
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.441
1w8cN69Cyclin-dependent kinase 22.7.11.220.441
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.441
2qo7ANPEphrin type-A receptor 32.7.10.10.441
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3a7jADPSerine/threonine-protein kinase 242.7.11.10.441
3eyhIZATyrosine-protein kinase JAK1/0.441
4ehzJAKTyrosine-protein kinase JAK1/0.441
4gub0Y4Casein kinase II subunit alpha2.7.11.10.441
5auwQUEDeath-associated protein kinase 12.7.11.10.441
5dn3ATPAurora kinase A2.7.11.10.441
2bmcMPYAurora kinase A2.7.11.10.440
2xneASHAurora kinase A2.7.11.10.440
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.440
3d5wADPSerine/threonine-protein kinase PLK/0.440
3iok1P6Tyrosine-protein kinase JAK2/0.440
3nwxKVSGag-Pol polyprotein3.4.23.160.440
3r71X86Cyclin-dependent kinase 22.7.11.220.440
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4erwSTUCyclin-dependent kinase 22.7.11.220.440
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.440