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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1nv8SAMRelease factor glutamine methyltransferase2.1.1.297

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1nv8SAMRelease factor glutamine methyltransferase2.1.1.2971.000
1nv9SAHRelease factor glutamine methyltransferase2.1.1.2970.651
1sg9SAMRelease factor glutamine methyltransferase2.1.1.2970.620
1vq1SAMRelease factor glutamine methyltransferase2.1.1.2970.602
1ve3SAMUncharacterized protein/0.457
4kvzSAHPtnL protein/0.457
3grrSAHProbable ribosomal RNA small subunit methyltransferase A/0.453
2np7NEAModification methylase TaqI2.1.1.720.447
3sr4TT8Histone-lysine N-methyltransferase, H3 lysine-79 specific2.1.1.430.446
1njeDCMThymidylate synthase/0.445
1nw3SAMHistone-lysine N-methyltransferase, H3 lysine-79 specific2.1.1.430.445
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
5bxySAHPutative RNA methylase family UPF0020/0.443
1jmiUMPThymidylate synthase/0.442