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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1njaDCMThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1njaDCMThymidylate synthase/1.000
1jmfUMPThymidylate synthase/0.646
1jmiUMPThymidylate synthase/0.637
1tsyUMPThymidylate synthase/0.635
1vzaUMPThymidylate synthase/0.606
1jmgUMPThymidylate synthase/0.599
1jmhUMPThymidylate synthase/0.574
1tsxUMPThymidylate synthase/0.565
1vzbUMPThymidylate synthase/0.561
1njeDCMThymidylate synthase/0.560
1njcDCMThymidylate synthase/0.552
1tsvUMPThymidylate synthase/0.552
1njdUMPThymidylate synthase/0.543
1lcbTMPThymidylate synthase/0.542
2tdmUMPThymidylate synthase/0.541
2g8aUMPThymidylate synthase/0.537
1bp6UMPThymidylate synthase/0.535
1thyUMPThymidylate synthase/0.515
2g86UMPThymidylate synthase/0.513
1bpjUMPThymidylate synthase/0.511
2g89UMPThymidylate synthase/0.503
2vetUMPThymidylate synthase/0.497
1bidUMPThymidylate synthase/0.494
1njbUMPThymidylate synthase/0.494
1bp0UMPThymidylate synthase/0.491
4einNOHThymidylate synthase2.1.1.450.490
1aobDDUThymidylate synthase/0.479
3bgxTMPThymidylate synthase/0.476
1bduDURThymidylate synthase/0.475
1lcbDHFThymidylate synthase/0.470
2g8dUMPThymidylate synthase/0.466
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.460
4iskUMPThymidylate synthase/0.460
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.459
1ci7UMPThymidylate synthase2.1.1.450.457
4eb4UMPThymidylate synthase2.1.1.450.449
1tdcUMPThymidylate synthase/0.446
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442