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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1nhhANPDNA mismatch repair protein MutL

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1nhhANPDNA mismatch repair protein MutL/1.000
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.522
2zkjADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.519
2e0aANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.494
1i59ANPChemotaxis protein CheA2.7.13.30.488
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.488
2zdyADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.479
4wudANPDNA gyrase subunit B/0.473
1i5aACPChemotaxis protein CheA2.7.13.30.452
3h4lANPDNA mismatch repair protein PMS1/0.450
4y9qC2EUncharacterized protein/0.450
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.448
4prvADPDNA gyrase subunit B/0.447
1i5bANPChemotaxis protein CheA2.7.13.30.445
1jm6ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.443
3zkdANPDNA gyrase subunit B/0.442
1z5cADPType 2 DNA topoisomerase 6 subunit B/0.440