Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.53

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.531.000
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.651
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.552
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.552
5jlaNADPutative short-chain dehydrogenase/reductase/0.551
3sx2NADUncharacterized protein/0.542
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.539
3ak4NADNADH-dependent quinuclidinone reductase/0.538
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.536
1ipeNDPTropinone reductase 21.1.1.2360.534
3wdsNADNADH-dependent quinuclidinone reductase/0.532
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.532
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.528
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.525
3s55NADPutative short-chain dehydrogenase/reductase/0.522
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.522
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.520
2wsbNADGalactitol dehydrogenase/0.520
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.519
4gh5NADShort-chain dehydrogenase/reductase SDR/0.519
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.518
1mg5NAIAlcohol dehydrogenase1.1.1.10.517
2dteNAIGlucose 1-dehydrogenase related protein/0.514
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.513
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.513
1iy8NADLevodione reductase/0.511
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.510
4fn4NADShort chain dehydrogenase/0.510
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.509
5idwNAPShort-chain dehydrogenase/reductase SDR/0.506
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.505
1snyNAPLD36273p/0.503
2wdzNADGalactitol dehydrogenase/0.503
3tscNADUncharacterized protein/0.501
5ig2NADShort-chain dehydrogenase/reductase SDR/0.500
3uxyNADShort-chain dehydrogenase/reductase SDR/0.499
1sbyNADAlcohol dehydrogenase1.1.1.10.495
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.495
4hwkNAPSepiapterin reductase1.1.1.1530.494
4j7uNAPSepiapterin reductase1.1.1.1530.494
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.493
3sjuNDPKeto reductase/0.493
1b15NAEAlcohol dehydrogenase1.1.1.10.492
5lc1NADL-threonine 3-dehydrogenase/0.492
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.491
3rj5NADAlcohol dehydrogenase1.1.1.10.491
1ae1NAPTropinone reductase 1/0.490
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.490
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.488
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.488
2yy7NADL-threonine dehydrogenase/0.487
3rj9NADAlcohol dehydrogenase1.1.1.10.484
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.484
4dc1NDPPutative ketoacyl reductase1.3.10.483
1b16NAQAlcohol dehydrogenase1.1.1.10.482
1w4zNAPPutative ketoacyl reductase1.3.10.482
4nbwNADShort-chain dehydrogenase/reductase SDR/0.482
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.481
3qrwNDPPutative ketoacyl reductase1.3.10.481
1xg5NAPDehydrogenase/reductase SDR family member 11/0.479
4j7xNAPSepiapterin reductase1.1.1.1530.479
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.479
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.479
1wntNAPL-xylulose reductase1.1.1.100.478
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.478
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.477
1x7gNAPPutative ketoacyl reductase1.3.10.477
1zemNADXylitol dehydrogenase/0.476
3d3wNAPL-xylulose reductase1.1.1.100.475
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.474
3p19NDPPutative blue fluorescent protein/0.474
1n5dNDPCarbonyl reductase [NADPH] 1/0.473
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.473
4qecNAPElxO/0.473
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.471
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.471
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.471
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.470
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.470
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.469
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.469
1x7hNDPPutative ketoacyl reductase1.3.10.468
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.468
4bmvNAPShort-chain dehydrogenase/0.468
4idgNADPutative UDP-glucose 4-epimerase/0.468
3lqfNADGalactitol dehydrogenase/0.466
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.466
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.466
3w8eNAD3-hydroxybutyrate dehydrogenase/0.464
3gy0NAPNAD(P)-dependent oxidoreductase/0.463
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.463
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
4yaiNAIC alpha-dehydrogenase/0.462
5jydNADShort chain dehydrogenase/0.462
3r3sNADPutative oxidoreductase/0.461
1b14NADAlcohol dehydrogenase1.1.1.10.460
1pr9NAPL-xylulose reductase1.1.1.100.460
2bd0NAPSepiapterin reductase/0.460
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.460
3a4vNADNDP-sugar epimerase/0.460
3wmxNADNAD dependent epimerase/dehydratase/0.460
4yagNAIC alpha-dehydrogenase/0.459
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
1xkqNDPUncharacterized protein/0.455
2yutNAPPutative short-chain oxidoreductase/0.453
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.453
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.452
3toxNAPPutative oxidoreductase/0.451
2gn8NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.450
1geeNADGlucose 1-dehydrogenase1.1.1.470.449
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.448
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.447
1oaaNAPSepiapterin reductase1.1.1.1530.446
4b8wNAPGDP-L-fucose synthase1.1.1.2710.443
1mgoNADAlcohol dehydrogenase E chain1.1.1.10.442
5jy1NADPutative short-chain dehydrogenase/reductase/0.442
1gcoNADGlucose 1-dehydrogenase1.1.1.470.441
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.441
2p5uNADUDP-glucose 4-epimerase/0.440
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.440
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.440
3ajrNADNDP-sugar epimerase/0.440
3tn7NJPShort-chain alcohol dehydrogenase/0.440