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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1nceCB3Thymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1nceCB3Thymidylate synthase/1.000
1tduCB3Thymidylate synthase/0.608
1dnaCB3Thymidylate synthase/0.565
1jtqLY3Thymidylate synthase/0.547
2bbqPFGThymidylate synthase/0.525
1dduCB3Thymidylate synthase/0.524
2ftoCB3Thymidylate synthase/0.517
1kziTHGThymidylate synthase/0.515
1an5CB3Thymidylate synthase/0.514
1zprCB3Thymidylate synthase/0.514
3bgxMEFThymidylate synthase/0.511
1fwmCB3Thymidylate synthase/0.504
1kzjCB3Thymidylate synthase/0.504
1f4fTP3Thymidylate synthase/0.503
1jtuLYBThymidylate synthase/0.503
2tscCB3Thymidylate synthase/0.501
1tysDHFThymidylate synthase/0.500
4knzCB3Thymidylate synthase/0.500
1trgCB3Thymidylate synthase/0.495
3bhlTHGThymidylate synthase/0.493
1kceCB3Thymidylate synthase/0.492
4gevCB3Thymidylate synthase/0.491
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.489
4fqsLYAThymidylate synthase ThyA/0.488
1bq1CB3Thymidylate synthase/0.484
1hvyD16Thymidylate synthase2.1.1.450.479
1aiqCB3Thymidylate synthase/0.478
1jutLYDThymidylate synthase/0.477
3bhrTHGThymidylate synthase/0.477
4isk1JYThymidylate synthase/0.470
1axwMTXThymidylate synthase/0.468
1ju6LYAThymidylate synthase2.1.1.450.465
1f4gTP4Thymidylate synthase/0.462
1jujLYAThymidylate synthase2.1.1.450.458
4fogC2FThymidylate synthase ThyA/0.451
2kceD16Thymidylate synthase/0.445
1synF89Thymidylate synthase/0.443