Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1nasASESepiapterin reductase1.1.1.153

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1nasASESepiapterin reductase1.1.1.1531.000
1sepBIOSepiapterin reductase1.1.1.1530.723
4hwkSFYSepiapterin reductase1.1.1.1530.595
4j7uYTZSepiapterin reductase1.1.1.1530.584
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.517
4j7xSASSepiapterin reductase1.1.1.1530.515
3jpuTY4Transcriptional activator protein LasR/0.511
1ppjANYCytochrome b/0.505
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.503
4rrxLURProstaglandin G/H synthase 21.14.99.10.503
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.499
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.499
3bk2U5PRibonuclease J/0.498
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.497
3h3t16HCollagen type IV alpha-3-binding protein/0.497
3h3qH13Collagen type IV alpha-3-binding protein/0.496
2hl2SSAThreonine--tRNA ligase6.1.1.30.494
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.491
2on6IMHPurine nucleoside phosphorylase2.4.2.10.489
2rkiTT1Gag-Pol polyprotein2.7.7.490.488
1cq7PY5Aspartate aminotransferase2.6.1.10.487
3w78CBDFMN-dependent NADH-azoreductase/0.487
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.485
2w6oOA3Biotin carboxylase6.3.4.140.484
1pxxDIFProstaglandin G/H synthase 21.14.99.10.483
2bfmTOPPteridine reductase 11.5.1.330.483
2qimZEAClass 10 plant pathogenesis-related protein/0.483
1fmlRTLRetinol dehydratase/0.482
1x8lOXRRetinol dehydratase/0.482
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.482
2xvw9NRSerum albumin/0.482
3b9lAZZSerum albumin/0.482
1v79FR7Adenosine deaminase3.5.4.40.481
1xmmM7Gm7GpppX diphosphatase3.6.1.590.481
3djfBC3Purine nucleoside phosphorylase/0.481
4lvg20ONicotinamide phosphoribosyltransferase2.4.2.120.481
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.480
4a83DXCMajor pollen allergen Bet v 1-A/0.480
4bfvZVVPantothenate kinase2.7.1.330.480
1umlFR4Adenosine deaminase3.5.4.40.479
5cb3APRO-acetyl-ADP-ribose deacetylase/0.479
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.478
1nw6SFGModification methylase RsrI2.1.1.720.478
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.478
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.478
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.478
3gy9COAGCN5-related N-acetyltransferase/0.478
3jzfJZKBiotin carboxylase6.3.4.140.478
3nmpPYVAbscisic acid receptor PYL2/0.478
4rrgA3TThreonine--tRNA ligase6.1.1.30.478
1h9zRWFSerum albumin/0.477
4jlm1NNDeoxycytidine kinase2.7.1.740.477
3p8zSAHGenome polyprotein2.1.1.560.475
5d7pOCZNAD-dependent protein deacetylase sirtuin-23.5.10.475
2bf7HBIPteridine reductase 11.5.1.330.474
3vtdTKDVitamin D3 receptor/0.474
3zs7ATPPyridoxine/pyridoxal/pyridoxamine kinase/0.474
4hy6FJ1Heat shock protein HSP 90-alpha/0.474
1i24UPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.473
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.473
3w5p4OAVitamin D3 receptor/0.473
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.473
1i2cUPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.472
1uyhPU0Heat shock protein HSP 90-alpha/0.472
2lzg13QE3 ubiquitin-protein ligase Mdm26.3.20.472
2po7CHDFerrochelatase, mitochondrial4.99.1.10.472
3h3r14HCollagen type IV alpha-3-binding protein/0.472
4gg70J8Hepatocyte growth factor receptor2.7.10.10.472
2bfpH4BPteridine reductase 11.5.1.330.471
2uxoTACHTH-type transcriptional regulator TtgR/0.471
3i587NA2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase/0.471
3v2uATPProtein GAL3/0.471
4h9506UDihydrofolate reductase1.5.1.30.471
4otyLURProstaglandin G/H synthase 21.14.99.10.471
1kphSAHCyclopropane mycolic acid synthase 12.1.1.790.470
1ndyFR3Adenosine deaminase3.5.4.40.470
1nw5SAMModification methylase RsrI2.1.1.720.470
1qjgEQUSteroid Delta-isomerase5.3.3.10.470
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.470
2w6nOA2Biotin carboxylase6.3.4.140.470
3elbC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.470
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.470
3sn6P0GBeta-2 adrenergic receptor/0.470
1l8qADPChromosomal replication initiator protein DnaA/0.469
2ydoADNAdenosine receptor A2a/0.469
3r5yF42Uncharacterized protein/0.469
4prxADPDNA gyrase subunit B/0.469
1lkeDOGBilin-binding protein/0.468
1srjNABStreptavidin/0.468
3dr1C5DVitamin D3 receptor A/0.468
3n8yDIFProstaglandin G/H synthase 11.14.99.10.468
3vtcTK3Vitamin D3 receptor/0.468
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.468
4bfuZVUPantothenate kinase2.7.1.330.468
5eghPCEctonucleotide pyrophosphatase/phosphodiesterase family member 6/0.468
1fmjRTLRetinol dehydratase/0.467
1swtBTNStreptavidin/0.467
3ix3OHNTranscriptional activator protein LasR/0.467
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.467
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.467
1e3rANDSteroid Delta-isomerase5.3.3.10.466
3dd0EZLCarbonic anhydrase 24.2.1.10.466
4rrwLURProstaglandin G/H synthase 21.14.99.10.466
4rrzLURProstaglandin G/H synthase 21.14.99.10.466
1n0uSO1Elongation factor 2/0.465
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.465
5cuqNSCGenome polyprotein/0.465
4zj8SUVOrexin receptor type 1/0.465
1al8DHPPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.464
1gvv0GMEndothiapepsin3.4.23.220.464
1kqwRTLCellular retinol-binding protein type II/0.464
2bfaCB3Pteridine reductase 11.5.1.330.464
3d5qT30Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.464
3h3sH15Collagen type IV alpha-3-binding protein/0.464
4cf23GMIntegrase/0.464
4rrrA3TThreonine--tRNA ligase6.1.1.30.464
1hb1OCVIsopenicillin N synthase1.21.3.10.463
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.463
1s1vTNKGag-Pol polyprotein2.7.7.490.463
2w6mOA1Biotin carboxylase6.3.4.140.463
2zi63D1Deoxycytidine kinase2.7.1.740.463
3gyaCOAGCN5-related N-acetyltransferase/0.463
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.463
4a31MYAGlycylpeptide N-tetradecanoyltransferase/0.463
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.463
4jnm1LJNicotinamide phosphoribosyltransferase2.4.2.120.463
1cqp803Integrin alpha-L/0.462
1v7aFRCAdenosine deaminase3.5.4.40.462
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.462
4iah1DXAlr2278 protein/0.462
4pkl1GHUncharacterized protein/0.462
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.462
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.461
1l0lFMXCytochrome b/0.461
1o6rR19Squalene--hopene cyclase4.2.1.1290.461
2izfBTNStreptavidin/0.461
2rqfJH3Hemolymph juvenile hormone binding protein/0.461
2uywBTNAvd protein/0.461
4bfzZVZPantothenate kinase2.7.1.330.461
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.461
5dcyNAPIridoid synthase1.3.1.990.461
2k1qGLU_LEU_IBU_OBF_FE3Polyprotein/0.460
3owuEQUSteroid Delta-isomerase5.3.3.10.460
3tm5SFGUncharacterized protein/0.460
4a81DXCMajor pollen allergen Bet v 1-A/0.460
4na4A1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.460
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.459
1b87ACOAac(6')-Ii protein/0.459
1bnnAL1Carbonic anhydrase 24.2.1.10.459
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.459
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.459
2i4qUA4Renin3.4.23.150.459
2impNAILactaldehyde dehydrogenase1.2.1.220.459
2uxpCLMHTH-type transcriptional regulator TtgR/0.459
3qizQI2Botulinum neurotoxin type A3.4.24.690.459
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.459
5ikqJMSProstaglandin G/H synthase 21.14.99.10.459
1bwlFMNNADPH dehydrogenase 11.6.99.10.458
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.458
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.458
3cseN22Uncharacterized protein/0.458
3d0bSNXHeat shock protein HSP 90-alpha/0.458
3ed1GA3Gibberellin receptor GID1/0.458
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
3pgiF41Endothiapepsin3.4.23.220.458
3r7cFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.458
3vgnFNNSteroid Delta-isomerase5.3.3.10.458
4azwATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.458
4dymIYZActivin receptor type-12.7.11.300.458
4ure1PSCyclohexanol dehydrogenase/0.458
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.457
2cy0NAPShikimate dehydrogenase (NADP(+))/0.457
2qhxFE1Pteridine reductase 11.5.1.330.457
2zymACXPeriplasmic binding protein/0.457
3a4pDFQHepatocyte growth factor receptor2.7.10.10.457
4ead0NPThymidine phosphorylase2.4.2.40.457
4mv1ADPBiotin carboxylase6.3.4.140.457
5eccNAPDehydrofolate reductase type I/0.457
1ay0TPPTransketolase 12.2.1.10.456
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
1r2jFADFkbI/0.456
1ve3SAMUncharacterized protein/0.456
2bxoOPBSerum albumin/0.456
2vb8TLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.456
2wi72KLHeat shock protein HSP 90-alpha/0.456
3csdEMOPutative ketoacyl reductase1.3.10.456
3eblGA4Gibberellin receptor GID1/0.456
3lzwNAPFerredoxin--NADP reductase 21.18.1.20.456
3opdHIEHeat shock protein 83/0.456
4a84DXCMajor pollen allergen Bet v 1-A/0.456
4ceqQCHIntegrase/0.456
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.455
1f4gTP4Thymidylate synthase/0.455
1ogxEQUSteroid Delta-isomerase5.3.3.10.455
1qxlFR8Adenosine deaminase3.5.4.40.455
2b0qADPAminoglycoside 3'-phosphotransferase2.7.1.950.455
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
2v58LZJBiotin carboxylase6.3.4.140.455
2w2vGTPRas-related C3 botulinum toxin substrate 2/0.455
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
3junAKDPhenazine biosynthesis protein A/B/0.455
3s1dZIRCytokinin dehydrogenase 11.5.99.120.455
4ax8SAMO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.455
4i6gFADCryptochrome-2/0.455
4jzr4JREgl nine homolog 1/0.455
1aquESTEstrogen sulfotransferase, testis isoform2.8.2.40.454
1ove358Mitogen-activated protein kinase 14/0.454
1s1rNAPAldo-keto reductase family 1 member C3/0.454
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
1zeoC01Peroxisome proliferator-activated receptor gamma/0.454
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.454
2rtnIMIStreptavidin/0.454
2x7hPFNProstaglandin reductase 310.454
2xvv9DNSerum albumin/0.454
3ho9N3A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.454
3iqhTYR_ASP_ILECysteine synthase2.5.1.470.454
3n61XFJNitric oxide synthase, brain1.14.13.390.454
3qlxQLRUncharacterized protein/0.454
4at4T6EBDNF/NT-3 growth factors receptor2.7.10.10.454
4bfwZVWPantothenate kinase2.7.1.330.454
4bwaN0BPyrrolysine--tRNA ligase/0.454
4dz7D02Carbonic anhydrase 24.2.1.10.454
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.454
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.454
4k0tD9ZCarbonic anhydrase 24.2.1.10.454
4pnmNU1Tankyrase-22.4.2.300.454
4xwtU5PRibonuclease J/0.454
4ys22BAUncharacterized protein/0.454
4z4pSAHHistone-lysine N-methyltransferase 2D2.1.1.430.454
5jr3SAHCarminomycin 4-O-methyltransferase DnrK2.1.1.2920.454
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.453
2pvkP45Casein kinase II subunit alpha2.7.11.10.453
2r4uADPGlycogen synthase2.4.1.210.453
2tscCB3Thymidylate synthase/0.453
2zb45OPProstaglandin reductase 21.3.1.480.453
3bgxMEFThymidylate synthase/0.453
3ew2BTNHypothetical conserved protein/0.453
3owsEQUSteroid Delta-isomerase5.3.3.10.453
3pd4A3GThreonine--tRNA ligase6.1.1.30.453
3pqbVGPPutative oxidoreductase/0.453
3zkyWT4Isopenicillin N synthase1.21.3.10.453
4bfxZVXPantothenate kinase2.7.1.330.453
4bhw01KHistone acetyltransferase p300/0.453
4du82P0Mevalonate diphosphate decarboxylase/0.453
4ho8THMGlucose-1-phosphate thymidylyltransferase/0.453
4o71CPBBromodomain-containing protein 4/0.453
4qzuRTLRetinol-binding protein 2/0.453
4relKMPGlycosyltransferase/0.453
4rr7A3SProbable threonine--tRNA ligase 26.1.1.30.453
3emlZMAAdenosine receptor A2a/0.453
1h35R01Squalene--hopene cyclase4.2.1.1290.452
1mczRMNBenzoylformate decarboxylase4.1.1.70.452
1u2rSO1Elongation factor 2/0.452
2uxuNARHTH-type transcriptional regulator TtgR/0.452
2ydbNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.452
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.452
3dleGFAGag-Pol polyprotein2.7.7.490.452
3eem53VUncharacterized protein/0.452
3exnACOProbable acetyltransferase/0.452
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
3fznD7KBenzoylformate decarboxylase4.1.1.70.452
3zbzOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.452
4askK0ILysine-specific demethylase 6B1.14.110.452
4j3mAJ8Tankyrase-22.4.2.300.452
4lva20MNicotinamide phosphoribosyltransferase2.4.2.120.452
4nieNBHNuclear receptor ROR-gamma/0.452
5cwa0GAAnthranilate synthase component 14.1.3.270.452
1e92HBIPteridine reductase 11.5.1.330.451
1fm4DXCMajor pollen allergen Bet v 1-L/0.451
1g3mPCQEstrogen sulfotransferase2.8.2.40.451
1lp4ANPCasein kinase II subunit alpha2.7.11.10.451
1qrrUPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.451
1z6tADPApoptotic protease-activating factor 1/0.451
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.451
2zbaZBATrichothecene 3-O-acetyltransferase/0.451
2zcvNDPQuinone oxidoreductase 21.6.5.20.451
3vt8YI3Vitamin D3 receptor/0.451
4a6eASEAcetylserotonin O-methyltransferase2.1.1.40.451
4iae1DXAlr2278 protein/0.451
4psbGA3Cytokinin-specific binding protein/0.451
4rrcA3TProbable threonine--tRNA ligase 26.1.1.30.451
5c1mCLRMu-type opioid receptor/0.451
1dduCB3Thymidylate synthase/0.450
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.450
1f0qEMOCasein kinase II subunit alpha2.7.11.10.450
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.450
1kqoDNDNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.450
2vo4GTB2,4-D inducible glutathione S-transferase/0.450
2wggTLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.450
2xvfFADPutative flavin-containing monooxygenase/0.450
3hub469Mitogen-activated protein kinase 14/0.450
3oom507Activin receptor type-12.7.11.300.450
3qeoLLTDeoxycytidine kinase2.7.1.740.450
3up3XCAaceDAF-12/0.450
3vt7VDXVitamin D3 receptor/0.450
3w5q3KLVitamin D3 receptor/0.450
1h36R88Squalene--hopene cyclase4.2.1.1290.449
1i05LTLMajor urinary protein 6/0.449
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.449
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.449
2imfTOM2-hydroxychromene-2-carboxylate isomerase5.99.1.40.449
2rtgBTNStreptavidin/0.449
2v59LZKBiotin carboxylase6.3.4.140.449
2vqqTFGHistone deacetylase 43.5.1.980.449
2xlrFADPutative flavin-containing monooxygenase/0.449
2xveFADPutative flavin-containing monooxygenase/0.449
3c3dFO12-phospho-L-lactate transferase/0.449
3eej53RUncharacterized protein/0.449
3p8iFMNPentaerythritol tetranitrate reductase/0.449
4as76LXKinesin-like protein KIF11/0.449
4c2jCOA3-ketoacyl-CoA thiolase, mitochondrial2.3.1.160.449
4f3i0S6Bromodomain-containing protein 4/0.449
4l0qNADAlcohol dehydrogenase class-3/0.449
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.449
1dajMOTDihydrofolate reductase1.5.1.30.448
1dggNDPCatalase1.11.1.60.448
2ea2F77Methionine aminopeptidase 2/0.448
2ea4F79Methionine aminopeptidase 2/0.448
2vkeTACTetracycline repressor protein class D/0.448
3adaNADSubunit alpha of sarocosine oxidase/0.448
3ln052BProstaglandin G/H synthase 21.14.99.10.448
3q2jCKIAminoglycoside 3'-phosphotransferase2.7.1.950.448
3q9zTXQCasein kinase II subunit alpha2.7.11.10.448
3tm4SAMUncharacterized protein/0.448
4awo99BHeat shock protein HSP 90-alpha/0.448
4jvr1MTE3 ubiquitin-protein ligase Mdm26.3.20.448
4xcxSAHSmall RNA 2'-O-methyltransferase/0.448
1cnyEG3Carbonic anhydrase 24.2.1.10.447
1i9hBNIStreptavidin/0.447
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.447
1opbRETRetinol-binding protein 2/0.447
1rj6AZMCarbonic anhydrase 144.2.1.10.447
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2brlPOOGenome polyprotein2.7.7.480.447
2cduADPNADH oxidase/0.447
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
2dxsJTPGenome polyprotein2.7.7.480.447
2gpvOHTEstrogen-related receptor gamma/0.447
2npfMOUElongation factor 2/0.447
2qzsADPGlycogen synthase2.4.1.210.447
2z4w749Geranylgeranyl pyrophosphate synthase/0.447
3eek53SUncharacterized protein/0.447
4cdmFO1Deoxyribodipyrimidine photolyase/0.447
4cjsL0YIntegrase/0.447
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.447
4mv8ACPBiotin carboxylase6.3.4.140.447
4xoqF42Coenzyme F420:L-glutamate ligase/0.447
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.447
1dgbNDPCatalase1.11.1.60.446
1f20FADNitric oxide synthase, brain1.14.13.390.446
1hb3SCVIsopenicillin N synthase1.21.3.10.446
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.446
1rx8FOLDihydrofolate reductase1.5.1.30.446
1wdkACO3-ketoacyl-CoA thiolase/0.446
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.446
2r0pK2CPutative FAD-monooxygenase/0.446
2vqoTFGHistone deacetylase 43.5.1.980.446
2xwyIB8Genome polyprotein2.7.7.480.446
2y60M8FIsopenicillin N synthase1.21.3.10.446
2yneNHWGlycylpeptide N-tetradecanoyltransferase/0.446
3dokGWJPol protein/0.446
3dyaPZLGag-Pol polyprotein2.7.7.490.446
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3ho2N323-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.446
3ix4TX1Transcriptional activator protein LasR/0.446
3n0nP9BCarbonic anhydrase 24.2.1.10.446
3vt9YI4Vitamin D3 receptor/0.446
3zv64HBCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.446
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.446
4a51DQ8Kinesin-like protein KIF11/0.446
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.446
4b4dFADFerredoxin-NADP reductase/0.446
4dpy2P0Mevalonate diphosphate decarboxylase/0.446
4fal0T0Aldo-keto reductase family 1 member C3/0.446
4fi1ATPCasein kinase II subunit alpha2.7.11.10.446
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.446
4y7cFADNADPH--cytochrome P450 reductase/0.446
5k2bZMAAdenosine receptor A2a/0.446
1b2lNDCAlcohol dehydrogenase1.1.1.10.445
1cjwCOTSerotonin N-acetyltransferase/0.445
1cq8PY6Aspartate aminotransferase2.6.1.10.445
1f5fDHTSex hormone-binding globulin/0.445
1kl2FONSerine hydroxymethyltransferase/0.445
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
1s7gNADNAD-dependent protein deacylase 2/0.445
1thnADPAnti-sigma F factor/0.445
1tvrTB9Gag-Pol polyprotein2.7.7.490.445
1w06W05Isopenicillin N synthase1.21.3.10.445
2acwUPGGlycosyltransferase/0.445
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.445
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
2c4iBTNAvidin/0.445
2g1n1IGRenin3.4.23.150.445
3busSAHDemethylrebeccamycin-D-glucose O-methyltransferase/0.445
3ey4352Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
3gf4UPGUDP-galactopyranose mutase5.4.99.90.445
3i2834NBifunctional epoxide hydrolase 23.3.2.100.445
3mtfA3FActivin receptor type-12.7.11.300.445
3w0uHPWLactoylglutathione lyase4.4.1.50.445
4bftZVTPantothenate kinase2.7.1.330.445
4bfyZVYPantothenate kinase2.7.1.330.445
4cgiNZLIntegrase/0.445
4kw51W6Decaprenylphosphoryl-beta-D-ribose oxidase/0.445
4qa0SHHHistone deacetylase 83.5.1.980.445
4rraA3TProbable threonine--tRNA ligase 26.1.1.30.445
4xivACPChemotaxis protein CheA2.7.13.30.445
1ddtAPUDiphtheria toxin/0.444
1e7qNAPGDP-L-fucose synthase/0.444
1ndzFR5Adenosine deaminase3.5.4.40.444
1oc1ASVIsopenicillin N synthase1.21.3.10.444
1oyaFMNNADPH dehydrogenase 11.6.99.10.444
1pd8CO4Dihydrofolate reductase1.5.1.30.444
1tg2H2BPhenylalanine-4-hydroxylase1.14.16.10.444
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2gzl2AA2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.444
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
2hl1A3SThreonine--tRNA ligase6.1.1.30.444
2j5sKTAAlr4455 protein/0.444
2p1t3TNRetinoic acid receptor RXR-alpha/0.444
2w4qCBWProstaglandin reductase 21.3.1.480.444
2yelWSHBromodomain-containing protein 4/0.444
2ywvADPPhosphoribosylaminoimidazole-succinocarboxamide synthase/0.444
3af1GDPPantothenate kinase2.7.1.330.444
3c14FOKAdenylate cyclase type 2/0.444
3c14FOKAdenylate cyclase type 5/0.444
3dlgGWEGag-Pol polyprotein2.7.7.490.444
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3fzwEQUSteroid Delta-isomerase5.3.3.10.444
3nmhPYVAbscisic acid receptor PYL2/0.444
3pd3A3TThreonine--tRNA ligase6.1.1.30.444
3q7dNPXProstaglandin G/H synthase 21.14.99.10.444
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.444
3t6iNC9Endothiapepsin3.4.23.220.444
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.444
4bz7B3NHistone deacetylase/0.444
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.444
4dru0LNGenome polyprotein2.7.7.480.444
4em9TCEPeroxisome proliferator-activated receptor gamma/0.444
4iraFAD4-hydroxyphenylacetate 3-monooxygenase/0.444
4ng2OHNTranscriptional activator protein LasR/0.444
4odoFK5Peptidyl-prolyl cis-trans isomerase/0.444
4trj665Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4wudANPDNA gyrase subunit B/0.444
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1dr3TAPDihydrofolate reductase1.5.1.30.443
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.443
1ly4COQDihydrofolate reductase1.5.1.30.443
1n3rGTPGTP cyclohydrolase 13.5.4.160.443
1s0xC3SNuclear receptor ROR-alpha/0.443
1wsvTHHAminomethyltransferase, mitochondrial/0.443
2bxqIMNSerum albumin/0.443
2fpcSCGStrictosidine synthase4.3.3.20.443
2g1s4IGRenin3.4.23.150.443
2hc4VDXVitamin D3 receptor A/0.443
2izhBTNStreptavidin/0.443
2jji0QSEndothiapepsin3.4.23.220.443
2pogWSTEstrogen receptor/0.443
3c3xNAPEugenol synthase 11.1.1.3180.443
3ddw055Glycogen phosphorylase, liver form2.4.1.10.443
3ekuCY9Actin-5C/0.443
3h0a9RARetinoic acid receptor RXR-alpha/0.443
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3kdiA8SAbscisic acid receptor PYL2/0.443
3mb601ICasein kinase II subunit alpha2.7.11.10.443
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.443
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.443
4aknS5BBromodomain-containing protein 2/0.443
4bcsBTNAvidin-related protein 4/5/0.443
4c67L5SBromodomain-containing protein 4/0.443
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.443
4qa2SHHHistone deacetylase 83.5.1.980.443
5g53NECAdenosine receptor A2a/0.443
1c7oPPGHemolysin/0.442
1h65GDPTranslocase of chloroplast 343.6.50.442
1vkgCRIHistone deacetylase 83.5.1.980.442
1wxyFRKAdenosine deaminase3.5.4.40.442
1zdwFLVPrenyltransferase/0.442
1zprCB3Thymidylate synthase/0.442
2fhnBNIAvidin-related protein 4/5/0.442
2v5aLZLBiotin carboxylase6.3.4.140.442
2w6zL21Biotin carboxylase6.3.4.140.442
2z7gEH9Adenosine deaminase3.5.4.40.442
2zjwREFCasein kinase II subunit alpha2.7.11.10.442
2zlcVDXVitamin D3 receptor/0.442
3dolGWIPol protein/0.442
3gdpFAD(R)-mandelonitrile lyase 24.1.2.100.442
3gwfNAPCyclohexanone monooxygenase/0.442
3ha3SAHHydroxymycolate synthase MmaA42.1.10.442
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3rvhHQ2Lysine-specific demethylase 4A1.14.110.442
3uvvREARetinoic acid receptor RXR-alpha/0.442
3vspEK8Peroxisome proliferator-activated receptor gamma/0.442
4cfaWOPIntegrase/0.442
4dbs0HVAldo-keto reductase family 1 member C3/0.442
4g67SAHUncharacterized ACR, COG1565 superfamily/0.442
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
4m9aFDAAcyl-CoA dehydrogenase/0.442
4o7uTHFThymidylate synthase/0.442
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
4rujVDXVitamin D3 receptor A/0.442
4y7cNAPNADPH--cytochrome P450 reductase/0.442
5il2SAHN6-adenosine-methyltransferase 70 kDa subunit/0.442
1bn1AL5Carbonic anhydrase 24.2.1.10.441
1d3dBZTProthrombin3.4.21.50.441
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.441
1l0cCOTSerotonin N-acetyltransferase/0.441
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.441
1r58AO5Methionine aminopeptidase 2/0.441
1uogP1CDeacetoxycephalosporin C synthase1.14.20.10.441
2a5yATPCell death protein 4/0.441
2g97DGBNicotinamide phosphoribosyltransferase2.4.2.120.441
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.441
2ociTYCValacyclovir hydrolase3.10.441
2uz2BTNAvd protein/0.441
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.441
2zwvSAHProbable ribosomal RNA small subunit methyltransferase/0.441
3cvkN34Genome polyprotein2.7.7.480.441
3f90FMNFlavodoxin/0.441
3inwJZBHeat shock protein HSP 90-alpha/0.441
3lz6A0DCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
3mknDNBPyrimidine-specific ribonucleoside hydrolase RihB/0.441
3mzcS6ICarbonic anhydrase 24.2.1.10.441
3nxtD2EDihydrofolate reductase1.5.1.30.441
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.441
3zeiAWHO-acetylserine sulfhydrylase/0.441
3zhsTD6Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.441
4bb3KKAIsopenicillin N synthase1.21.3.10.441
4l1xSTRAldo-keto reductase family 1 member C2/0.441
4n1gCEIObelin/0.441
4olfHFGProline--tRNA ligase6.1.1.150.441
4rjeFNRLactate oxidase/0.441
4rnxFMNNADPH dehydrogenase 11.6.99.10.441
4wdfA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.441
4xba5GPAprataxin-like protein30.441
5agyGTBTau class glutathione S-transferase/0.441
5jr34MUCarminomycin 4-O-methyltransferase DnrK2.1.1.2920.441
5uviZMAAdenosine receptor A2a/0.441
1d4pBPPProthrombin3.4.21.50.440
1eioGCHGastrotropin/0.440
1nenDNTSuccinate dehydrogenase iron-sulfur subunit1.3.5.10.440
1nenDNTSuccinate dehydrogenase cytochrome b556 subunit/0.440
1rk3VDXVitamin D3 receptor/0.440
1rszDIHPurine nucleoside phosphorylase2.4.2.10.440
1vyrFMNPentaerythritol tetranitrate reductase/0.440
1y0s331Peroxisome proliferator-activated receptor delta/0.440
2aylFLPProstaglandin G/H synthase 11.14.99.10.440
2c0cNAPProstaglandin reductase 310.440
2f8pCEIObelin/0.440
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.440
2iko7IGRenin3.4.23.150.440
2jb4A14Isopenicillin N synthase1.21.3.10.440
2p1v5TNRetinoic acid receptor RXR-alpha/0.440
2wleCOAPolysialic acid O-acetyltransferase/0.440
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.440
2ym1FADPhenylacetone monooxygenase1.14.13.920.440
3b6pTMPThree-prime repair exonuclease 13.1.11.20.440
3bhrTHGThymidylate synthase/0.440
3dhcCYKN-acyl homoserine lactonase AiiA3.1.1.810.440
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3ewkFADSensory box histidine kinase/response regulator/0.440
3ielU5PRibonuclease TTHA02523.10.440
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.470.440
3ix8TX3Transcriptional activator protein LasR/0.440
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3ldfSAHUncharacterized protein/0.440
3mytEQUSteroid Delta-isomerase5.3.3.10.440
3oysOYSCarbonic anhydrase 24.2.1.10.440
3vt65YIVitamin D3 receptor/0.440
4a2jAS0Progesterone receptor/0.440
4bis8HQLysine-specific demethylase 4A1.14.110.440
4c6zTLE3-oxoacyl-ACP synthase/0.440
4eh9IRGMitogen-activated protein kinase 14/0.440
4f3gKAIGlutamate receptor 3/0.440
4hu1V13Carbonic anhydrase 134.2.1.10.440
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4jazSTLPeroxisome proliferator-activated receptor gamma/0.440
4mihFADPyranose 2-oxidase1.1.3.100.440
4tvbNADHomospermidine synthase2.5.1.440.440
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.440
5jy1NADPutative short-chain dehydrogenase/reductase/0.440
4k5y1Q5Corticotropin-releasing factor receptor 1/0.440
4s0vSUVOrexin receptor type 2/0.440