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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/1.000
1n95HFPProtein farnesyltransferase subunit beta2.5.1.581.000
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.885
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.676
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.606
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.600
1s63778Protein farnesyltransferase subunit beta2.5.1.580.598
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.590
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.581
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.578
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.576
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.572
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.563
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.563
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.555
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.551
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.541
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.540
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.529
1ni12C5Protein farnesyltransferase subunit beta2.5.1.580.523
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.513
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.506
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.505
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.503
4lnbED5CaaX farnesyltransferase beta subunit Ram1/0.498
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.495
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.494
1n4qLYS_CYS_VAL_ILE_LEUGeranylgeranyl transferase type-1 subunit beta2.5.1.590.481
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.480
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.476
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.476
3q7fED2Uncharacterized protein/0.464