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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.59

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.591.000
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.653
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.494
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.493
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.489
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.487
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.479
1n4qLYS_CYS_VAL_ILE_LEUGeranylgeranyl transferase type-1 subunit beta2.5.1.590.464
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.461
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.459
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.459
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.453
1s63778Protein farnesyltransferase subunit beta2.5.1.580.453
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.453
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.445
3q7fED2Uncharacterized protein/0.441