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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1n4qLYS_CYS_VAL_ILE_LEUGeranylgeranyl transferase type-1 subunit beta2.5.1.59

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1n4qLYS_CYS_VAL_ILE_LEUGeranylgeranyl transferase type-1 subunit beta2.5.1.591.000
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.600
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.580
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.534
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.530
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.529
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.529
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.529
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.511
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.511
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.501
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.500
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.500
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.499
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.495
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.495
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.493
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.485
1s63778Protein farnesyltransferase subunit beta2.5.1.580.474
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.471
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.466
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.464
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.464
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.455
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.450
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.444