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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1n2jPAFPantothenate synthetase6.3.2.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1n2jPAFPantothenate synthetase6.3.2.11.000
5hg0SAMPantothenate synthetase/0.601
1n2iPAJPantothenate synthetase6.3.2.10.592
2x3fAPCPantothenate synthetase/0.580
3coy53HPantothenate synthetase6.3.2.10.577
3isjA8DPantothenate synthetase6.3.2.10.576
3ioeA7DPantothenate synthetase6.3.2.10.565
3iocA5DPantothenate synthetase6.3.2.10.562
3iodA6DPantothenate synthetase6.3.2.10.549
3cow52HPantothenate synthetase6.3.2.10.548
3ivxFG6Pantothenate synthetase6.3.2.10.538
3coz54HPantothenate synthetase6.3.2.10.534
1n2bPAFPantothenate synthetase6.3.2.10.531
3ivgFG5Pantothenate synthetase6.3.2.10.527
1n2gAPCPantothenate synthetase6.3.2.10.526
1n2hPAJPantothenate synthetase6.3.2.10.525
3ag6PAJPantothenate synthetase/0.520
3imeBZ2Pantothenate synthetase6.3.2.10.512
5kwvANPPantothenate synthetase/0.507
3imgBZ2Pantothenate synthetase6.3.2.10.504
4de50JDPantothenate synthetase6.3.2.10.500
3iobA4DPantothenate synthetase6.3.2.10.485
3d91REMRenin3.4.23.150.480
3fsuFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.470
1f8wFADNADH peroxidase1.11.1.10.469
3x2eNAIAdenosylhomocysteinase/0.466
1foaUD1Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase2.4.1.1010.459
1rfvADPPyridoxal kinase2.7.1.350.459
3ivcFG4Pantothenate synthetase6.3.2.10.457
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.457
4klaCHDFerrochelatase, mitochondrial4.99.1.10.456
1kp3ATPArgininosuccinate synthase6.3.4.50.453
2fznFADBifunctional protein PutA1.5.5.20.452
1rfuADPPyridoxal kinase2.7.1.350.451
4bfsZVSPantothenate kinase2.7.1.330.450
2v2qNVG4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.449
4ambDUDPutative glycosyl transferase/0.449
4wsoNADProbable nicotinate-nucleotide adenylyltransferase/0.449
2cv2GSUGlutamate--tRNA ligase6.1.1.170.448
1n2eAPCPantothenate synthetase6.3.2.10.446
1zp4FAD5,10-methylenetetrahydrofolate reductase1.5.1.200.446
3h3t16HCollagen type IV alpha-3-binding protein/0.446
2bn4FMNNADPH--cytochrome P450 reductase/0.445
1b5tFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.443
1qpl587Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.443
2iyfERYOleandomycin glycosyltransferase2.4.10.443
3ohh3HHBeta-secretase 13.4.23.460.443
3qe2FMNNADPH--cytochrome P450 reductase/0.443
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3m4p4ADAsparaginyl-tRNA synthetase, putative/0.442
1c9k5GPBifunctional adenosylcobalamin biosynthesis protein CobU/0.441
3u9eCOALmo1369 protein/0.441
1ja1FMNNADPH--cytochrome P450 reductase/0.440
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.440
4a0rDTBBifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial6.3.3.30.440