scPDB - Distribution of Binding site Similarity values of 1mvs entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1mvs	DTM	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	1.000
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.737
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.667
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.628
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.624
1u71	MXA	Dihydrofolate reductase	1.5.1.3	0.623
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.612
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.607
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.599
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.598
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.594
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.585
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.577
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.561
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.548
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.524
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.508
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.504
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.502
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.498
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.490
2jb4	A14	Isopenicillin N synthase	1.21.3.1	0.489
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.488
2y6f	M9F	Isopenicillin N synthase	1.21.3.1	0.487
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.483
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.482
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.482
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.479
1bk0	ACV	Isopenicillin N synthase	1.21.3.1	0.475
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.474
1w06	W05	Isopenicillin N synthase	1.21.3.1	0.470
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.467
2cig	1DG	Dihydrofolate reductase	1.5.1.3	0.467
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.467
2ivi	ACW	Isopenicillin N synthase	1.21.3.1	0.466
2vbd	V10	Isopenicillin N synthase	1.21.3.1	0.466
2y60	M8F	Isopenicillin N synthase	1.21.3.1	0.466
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.464
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.464
2vbp	VB1	Isopenicillin N synthase	1.21.3.1	0.463
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.463
3zoi	M2W	Isopenicillin N synthase	1.21.3.1	0.463
2wo7	ASV	Isopenicillin N synthase	1.21.3.1	0.462
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.462
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.460
1hb1	OCV	Isopenicillin N synthase	1.21.3.1	0.460
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.460
1dr2	TAP	Dihydrofolate reductase	1.5.1.3	0.459
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.459
2uag	UMA	UDP-N-acetylmuramoylalanine--D-glutamate ligase	6.3.2.9	0.459
2vcm	M11	Isopenicillin N synthase	1.21.3.1	0.458
1oc1	ASV	Isopenicillin N synthase	1.21.3.1	0.457
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.457
1qiq	ACC	Isopenicillin N synthase	1.21.3.1	0.456
1ia3	TQ5	Dihydrofolate reductase	1.5.1.3	0.455
1hb3	SCV	Isopenicillin N synthase	1.21.3.1	0.454
1bzf	TMQ	Dihydrofolate reductase	1.5.1.3	0.453
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.453
1uzw	CDH	Isopenicillin N synthase	1.21.3.1	0.453
4anx	534	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.453
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.453
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.452
2e98	B29	Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	2.5.1.31	0.452
4bbh	YBN	Glycylpeptide N-tetradecanoyltransferase	/	0.450
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.449
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.449
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.448
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.448
2abj	CBC	Branched-chain-amino-acid aminotransferase, cytosolic	2.6.1.42	0.447
1qjf	ACS	Isopenicillin N synthase	1.21.3.1	0.445
2ktd	PUC	Prostaglandin-H2 D-isomerase	5.3.99.2	0.445
3ada	NAD	Subunit alpha of sarocosine oxidase	/	0.445
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.444
3p3z	P3Z	Putative cytochrome P450	/	0.444
4ej1	FOL	Dihydrofolate reductase	1.5.1.3	0.444
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.443
1uho	VDN	cGMP-specific 3',5'-cyclic phosphodiesterase	/	0.443
4jib	1L6	cGMP-dependent 3',5'-cyclic phosphodiesterase	3.1.4.17	0.443
1dis	BDM	Dihydrofolate reductase	1.5.1.3	0.442
3is9	AC7	Gag-Pol polyprotein	2.7.7.49	0.442
1rx6	DDF	Dihydrofolate reductase	1.5.1.3	0.441
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.441
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.441
3vt7	VDX	Vitamin D3 receptor	/	0.441
4at0	FAD	Possible succinate dehydrogenase	/	0.441
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.440
1x8l	OXR	Retinol dehydratase	/	0.440
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.440
4x5j	FOL	Dihydrofolate reductase	1.5.1.3	0.440