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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1mraAPGMandelate racemase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1mraAPGMandelate racemase/1.000
1mdrAPGMandelate racemase/0.560
3bsyACOUDP-N-acetylbacillosamine N-acetyltransferase2.3.1.2030.512
1xddAAYIntegrin alpha-L/0.511
3zeiAWHO-acetylserine sulfhydrylase/0.503
3ed1GA3Gibberellin receptor GID1/0.501
1mrqSTRAldo-keto reductase family 1 member C1/0.499
1towCRZFatty acid-binding protein, adipocyte/0.499
4bfxZVXPantothenate kinase2.7.1.330.498
1ndzFR5Adenosine deaminase3.5.4.40.496
1cqp803Integrin alpha-L/0.495
1foaUD1Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase2.4.1.1010.494
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.492
2gouFMNNADH:flavin oxidoreductase Sye1/0.491
3qeoLLTDeoxycytidine kinase2.7.1.740.491
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.491
4tvbNADHomospermidine synthase2.5.1.440.491
1lb9DNQGlutamate receptor 2/0.489
3nmpPYVAbscisic acid receptor PYL2/0.489
4ba5PXGProbable aminotransferase/0.488
4s1iPLPPyridoxal kinase, putative/0.488
1v79FR7Adenosine deaminase3.5.4.40.487
3nr4PYVAbscisic acid receptor PYL2/0.487
4awsFMNNADH:flavin oxidoreductase Sye1/0.487
1hfqMOTDihydrofolate reductase1.5.1.30.486
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.486
1mdlSMNMandelate racemase/0.484
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.484
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.484
4b4w9L9Bifunctional protein FolD/0.484
1qxlFR8Adenosine deaminase3.5.4.40.483
1yw8A75Methionine aminopeptidase 2/0.483
2gv8NDPThiol-specific monooxygenase1.14.130.483
4awtFMNNADH:flavin oxidoreductase Sye1/0.483
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.482
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.482
1upw444Oxysterols receptor LXR-beta/0.482
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.482
4bfsZVSPantothenate kinase2.7.1.330.482
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.481
1jpaANPEphrin type-B receptor 22.7.10.10.481
1pq944BOxysterols receptor LXR-beta/0.481
2ea2F77Methionine aminopeptidase 2/0.481
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.481
1ftlDNQGlutamate receptor 2/0.480
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.479
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.478
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.478
4fevPP1Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.478
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.478
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.478
2w6zL21Biotin carboxylase6.3.4.140.477
1a8rGTPGTP cyclohydrolase 13.5.4.160.476
1kqwRTLCellular retinol-binding protein type II/0.476
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.476
2po7CHDFerrochelatase, mitochondrial4.99.1.10.476
3fr4F8AFatty acid-binding protein, adipocyte/0.476
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.476
4bfq083Soluble acetylcholine receptor/0.476
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.476
4fweFADLysine-specific histone demethylase 1B10.476
4g95OAGDihydrofolate reductase1.5.1.30.476
4itmATPTetraacyldisaccharide 4'-kinase/0.476
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.475
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.475
1cs4FOKAdenylate cyclase type 2/0.474
1cs4FOKAdenylate cyclase type 5/0.474
1wxjIPLTryptophan synthase alpha chain/0.474
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.474
3iktNADRedox-sensing transcriptional repressor Rex/0.474
3nmnPYVAbscisic acid receptor PYL1/0.474
3ojiPYVAbscisic acid receptor PYL3/0.474
4y0kNAPAntE/0.474
4fhf0TTSpore photoproduct lyase/0.473
1m8gNADNicotinamide-nucleotide adenylyltransferase2.7.7.10.472
3hy310F5-formyltetrahydrofolate cyclo-ligase6.3.3.20.472
3lfzADPUncharacterized protein MJ1225/0.472
4xz3COAAcyl-CoA synthetase (NDP forming)/0.472
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
3pm9FADPutative oxidoreductase/0.471
4m4922YL-lactate dehydrogenase A chain1.1.1.270.471
3ba6AN2Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.470
3nmvPYVAbscisic acid receptor PYL2/0.470
3rbqGLY_ALA_GLY_ALA_DAOProtein unc-119 homolog A/0.470
3tm5SFGUncharacterized protein/0.470
4dz5NAPAldo-keto reductase family 1 member C3/0.470
4fhd0TTSpore photoproduct lyase/0.470
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.470
2xviFADPutative flavin-containing monooxygenase/0.469
3qvrFADGlucose oxidase1.1.3.40.469
3uyk0CXProbable NDP-rhamnosyltransferase/0.469
3v1s0LHStrictosidine synthase4.3.3.20.469
4bis8HQLysine-specific demethylase 4A1.14.110.469
4g3jVNTLanosterol 14-alpha-demethylase/0.469
4v12POGMaoC like domain protein/0.469
5kgjACOPredicted acetyltransferase/0.469
1udaUFGUDP-glucose 4-epimerase5.1.3.20.468
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.468
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.468
3p62FMNPentaerythritol tetranitrate reductase/0.468
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.468
4rraA3TProbable threonine--tRNA ligase 26.1.1.30.468
2hdjNDPAldo-keto reductase family 1 member C2/0.467
2w6qOA5Biotin carboxylase6.3.4.140.467
2z7gEH9Adenosine deaminase3.5.4.40.467
3gncQQQGlutaryl-CoA dehydrogenase/0.467
4qzuRTLRetinol-binding protein 2/0.467
5c1mCLRMu-type opioid receptor/0.467
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.466
1knpFADL-aspartate oxidase1.4.3.160.466
1n2iPAJPantothenate synthetase6.3.2.10.466
2ab8MTPAdenosine kinase2.7.1.200.466
2dvlFADAcyl-CoA dehydrogenase/0.466
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.466
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.466
3p8iFMNPentaerythritol tetranitrate reductase/0.466
3p9tTCLRepressor/0.466
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.466
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.466
1fw0KAIGlutamate receptor 2/0.465
1ne6SP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.465
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.465
2d81RB3Poly(3-hydroxybutyrate) depolymerase/0.465
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.465
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
3v94WYQPhosphodiesterase/0.465
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
4xfjANPArgininosuccinate synthase/0.465
1ppjANYCytochrome b/0.464
2rjp886A disintegrin and metalloproteinase with thrombospondin motifs 43.4.24.820.464
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.464
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.464
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.464
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.464
1c7oPPGHemolysin/0.463
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.463
2hl2SSAThreonine--tRNA ligase6.1.1.30.463
2w6pOA4Biotin carboxylase6.3.4.140.463
3ddw055Glycogen phosphorylase, liver form2.4.1.10.463
3elbC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.463
4g090VDHistidinol dehydrogenase/0.463
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.463
4oicA8SBet v I allergen-like/0.463
4tx9AMZPhosphoribosyl isomerase A/0.463
1eirBPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.462
1jnzFADAdenylylsulfate reductase, subunit A (AprA)/0.462
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
1ygkRRCPyridoxal kinase2.7.1.350.462
1yqsBSAD-alanyl-D-alanine carboxypeptidase3.4.16.40.462
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.462
2v59LZKBiotin carboxylase6.3.4.140.462
3gwfFADCyclohexanone monooxygenase/0.462
3h3qH13Collagen type IV alpha-3-binding protein/0.462
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.10.462
4bewACPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.462
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.462
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.462
1afsTES3-alpha-hydroxysteroid dehydrogenase1.1.1.500.461
1b2lNDCAlcohol dehydrogenase1.1.1.10.461
1diuBDMDihydrofolate reductase1.5.1.30.461
1kdmDHTSex hormone-binding globulin/0.461
1qsnCOAHAT A1/0.461
1rkpIBMcGMP-specific 3',5'-cyclic phosphodiesterase/0.461
1umlFR4Adenosine deaminase3.5.4.40.461
2od7A1RNAD-dependent protein deacetylase HST23.5.10.461
2wyaHMGHydroxymethylglutaryl-CoA synthase, mitochondrial2.3.3.100.461
2x7hPFNProstaglandin reductase 310.461
3cgbCOACoenzyme A disulfide reductase/0.461
3h03UBPGlutamate receptor 2/0.461
3kb0A8SAbscisic acid receptor PYL2/0.461
3oafOAGDihydrofolate reductase1.5.1.30.461
3v2uATPProtein GAL3/0.461
4a86H35Major pollen allergen Bet v 1-A/0.461
4hkfACOAlpha-tubulin N-acetyltransferase 1/0.461
5fm7ADPRuvB-like helicase/0.461
1akcPPEAspartate aminotransferase, mitochondrial2.6.1.10.460
1kp2ATPArgininosuccinate synthase6.3.4.50.460
1lf3EH5Plasmepsin-23.4.23.390.460
1ndyFR3Adenosine deaminase3.5.4.40.460
1rd4L08Integrin alpha-L/0.460
1tkaN3TTransketolase 12.2.1.10.460
1xzqFONtRNA modification GTPase MnmE3.6.50.460
2cy2ACOProbable acetyltransferase/0.460
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.460
2xf3J01Uncharacterized protein/0.460
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.460
3ns2PYVAbscisic acid receptor PYL2/0.460
3wv9FEGHmd co-occurring protein HcgE/0.460
4bfuZVUPantothenate kinase2.7.1.330.460
1q20PLOSulfotransferase family cytosolic 2B member 12.8.2.20.459
2qbs024Tyrosine-protein phosphatase non-receptor type 13.1.3.480.459
3fhxPLPPyridoxal kinase2.7.1.350.459
3ibdCPZCytochrome P450 2B61.14.130.459
3kdiA8SAbscisic acid receptor PYL2/0.459
3p67FMNPentaerythritol tetranitrate reductase/0.459
4i1nFOLDihydrofolate reductase1.5.1.30.459
4ixd1HVIntegrin alpha-L/0.459
4kc2WS2Histo-blood group ABO system transferase/0.459
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.459
5fd8A5APutative carboxypeptidase yocD/0.459
1g8oU5PN-acetyllactosaminide alpha-1,3-galactosyltransferase/0.458
1jtqLY3Thymidylate synthase/0.458
1kw9BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.458
1ve3SAMUncharacterized protein/0.458
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.458
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
1yhjR6CPyridoxal kinase2.7.1.350.458
2ea4F79Methionine aminopeptidase 2/0.458
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.458
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.458
2izkGLLStreptavidin/0.458
2vq7NAPPutative flavin-containing monooxygenase/0.458
3c35KAIGlutamate receptor ionotropic, kainate 1/0.458
3otwCOAPhosphopantetheine adenylyltransferase/0.458
3tk3CPZCytochrome P450 2B41.14.14.10.458
3vi5M4MHematopoietic prostaglandin D synthase/0.458
3w0tHPULactoylglutathione lyase4.4.1.50.458
3w6hAZMCarbonic anhydrase 14.2.1.10.458
4gt8ADPSensor protein VraS2.7.13.30.458
4jlm1NNDeoxycytidine kinase2.7.1.740.458
4qx5CMPcGMP-dependent protein kinase 12.7.11.120.458
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.458
4yaw2AMNADPH--cytochrome P450 reductase/0.458
5gcnCOAHAT A1/0.458
1fvpFMANon-fluorescent flavoprotein/0.457
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.457
1obnASVIsopenicillin N synthase1.21.3.10.457
1uyhPU0Heat shock protein HSP 90-alpha/0.457
2oazI96Methionine aminopeptidase 2/0.457
2z4sADPChromosomal replication initiator protein DnaA/0.457
3c14FOKAdenylate cyclase type 2/0.457
3c14FOKAdenylate cyclase type 5/0.457
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.457
3fr5I4AFatty acid-binding protein, adipocyte/0.457
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.457
4azwATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.457
4dk70KSOxysterols receptor LXR-beta/0.457
4kbyC2EStimulator of interferon genes protein/0.457
4kq1U5PGlycogen [starch] synthase/0.457
1ek5NADUDP-glucose 4-epimerase/0.456
1kw6BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.456
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.456
2bu9HFVIsopenicillin N synthase1.21.3.10.456
2vbdV10Isopenicillin N synthase1.21.3.10.456
3fr28CAFatty acid-binding protein, adipocyte/0.456
3ojgHL4Phosphotriesterase/0.456
3pdqKC6Lysine-specific demethylase 4A1.14.110.456
3vilSA0Beta-glucosidase/0.456
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.456
4bftZVTPantothenate kinase2.7.1.330.456
4dyp0MSNucleoprotein/0.456
4gevCB3Thymidylate synthase/0.456
4gutFADLysine-specific histone demethylase 1B10.456
1b5eDCMDeoxycytidylate 5-hydroxymethyltransferase2.1.2.80.455
1ltzHBIPhenylalanine-4-hydroxylase1.14.16.10.455
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
2r8oT5XTransketolase 1/0.455
2zi63D1Deoxycytidine kinase2.7.1.740.455
2zsiGA4Gibberellin receptor GID1A30.455
3h3r14HCollagen type IV alpha-3-binding protein/0.455
3q7fED2Uncharacterized protein/0.455
3r1rATPRibonucleoside-diphosphate reductase 1 subunit alpha1.17.4.10.455
4c717RD3-oxoacyl-ACP synthase/0.455
4gncASORegucalcin3.1.1.170.455
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.455
4rp8ASCAscorbate-specific PTS system EIIC component/0.455
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
1oj4CDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.454
1zisINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.454
2flhZEACytokinin-specific binding protein/0.454
2g78REACellular retinoic acid-binding protein 2/0.454
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.454
2v58LZJBiotin carboxylase6.3.4.140.454
2zbaZBATrichothecene 3-O-acetyltransferase/0.454
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.454
3eksCY9Actin-5C/0.454
3kn03TOBeta-secretase 13.4.23.460.454
3oqkS52Renin3.4.23.150.454
3v0m5GWHisto-blood group ABO system transferase/0.454
3vmmP0DAlanine--anticapsin ligase/0.454
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.454
4jtrIZPAldo-keto reductase family 1 member C2/0.454
4kq2U5PGlycogen [starch] synthase isoform 22.4.1.110.454
4mv1ADPBiotin carboxylase6.3.4.140.454
4rheFMNFlavin prenyltransferase UbiX/0.454
4ryvZEAProtein LlR18A/0.454
5kghACOPredicted acetyltransferase/0.454
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.453
1g6oADPCag alpha/0.453
1kw8BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.453
1onpFOM1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.453
1r5hAO2Methionine aminopeptidase 2/0.453
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.453
1xmmM7Gm7GpppX diphosphatase3.6.1.590.453
1z7yAA5Cysteine synthase 12.5.1.470.453
2acwUPGGlycosyltransferase/0.453
2ahvCOAAcetate CoA-transferase YdiF2.8.3.80.453
2hk9NAPShikimate dehydrogenase (NADP(+))/0.453
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.453
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.453
3h3sH15Collagen type IV alpha-3-binding protein/0.453
4bb3KKAIsopenicillin N synthase1.21.3.10.453
4gxs0YSGlutamate receptor 2/0.453
4xo7ASDAldo-keto reductase family 1 member C2/0.453
5kf2ACOPredicted acetyltransferase/0.453
1blzACVIsopenicillin N synthase1.21.3.10.452
1lwxAZDNucleoside diphosphate kinase, cytosolic2.7.4.60.452
1n3sGTPGTP cyclohydrolase 13.5.4.160.452
1u1jC2F5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 12.1.1.140.452
1vkgCRIHistone deacetylase 83.5.1.980.452
1yw7A41Methionine aminopeptidase 2/0.452
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.452
3c3xNAPEugenol synthase 11.1.1.3180.452
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.452
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.452
3qt62P0Mevalonate diphosphate decarboxylase/0.452
3vi7CBDHematopoietic prostaglandin D synthase/0.452
3zhqTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.452
4eb5PLPCysteine desulfurase IscS 2/0.452
4edz0O5Hematopoietic prostaglandin D synthase/0.452
4elb34RDihydrofolate reductase/0.452
4imfSI3N-acetylneuraminate lyase/0.452
4mv8ACPBiotin carboxylase6.3.4.140.452
1h35R01Squalene--hopene cyclase4.2.1.1290.451
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.451
1vbiNADMalate/L-lactate dehydrogenase family protein/0.451
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
2pg0FADAcyl-CoA dehydrogenase/0.451
2pncCLUPrimary amine oxidase, liver isozyme/0.451
2qs1UB1Glutamate receptor ionotropic, kainate 1/0.451
3coz54HPantothenate synthetase6.3.2.10.451
3elySAHMethyltransferase/0.451
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3p5pA3CTaxadiene synthase4.2.3.170.451
4bfwZVWPantothenate kinase2.7.1.330.451
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
4ds8A8SAbscisic acid receptor PYL3/0.451
4ho6UTPGlucose-1-phosphate thymidylyltransferase/0.451
4kc1WS1Histo-blood group ABO system transferase/0.451
4rrqA3SThreonine--tRNA ligase6.1.1.30.451
1e2nRCAThymidine kinase/0.450
1r58AO5Methionine aminopeptidase 2/0.450
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.450
2gevCOKPantothenate kinase2.7.1.330.450
2nnqT4BFatty acid-binding protein, adipocyte/0.450
2r5nTPPTransketolase 1/0.450
2vcwZZAHematopoietic prostaglandin D synthase/0.450
2vcxD26Hematopoietic prostaglandin D synthase/0.450
2w6mOA1Biotin carboxylase6.3.4.140.450
2wi72KLHeat shock protein HSP 90-alpha/0.450
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.450
2zrxFMNIsopentenyl-diphosphate delta-isomerase/0.450
3fhxPXLPyridoxal kinase2.7.1.350.450
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.450
3ujlA8SAbscisic acid receptor PYL2/0.450
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.450
4bfvZVVPantothenate kinase2.7.1.330.450
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.450
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.450
4kx6FADFumarate reductase flavoprotein subunit1.3.5.40.450
4lrrCF9Thymidylate synthase/0.450
4rrlA3SProbable threonine--tRNA ligase 26.1.1.30.450
1cbqRE9Cellular retinoic acid-binding protein 2/0.449
1sreHABStreptavidin/0.449
1xr2C2F5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase2.1.1.140.449
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
2ejzSAHDiphthine synthase/0.449
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2gqaFMNNADH:flavin oxidoreductase Sye1/0.449
2iiqC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.449
2r8pT6FTransketolase 1/0.449
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
2wugHPK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.449
2zi53L1Deoxycytidine kinase2.7.1.740.449
2zshGA3Gibberellin receptor GID1A30.449
3ahiHTLProbable phosphoketolase/0.449
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3f03FMNPentaerythritol tetranitrate reductase/0.449
3fsjD7KBenzoylformate decarboxylase4.1.1.70.449
3qiyQI1Botulinum neurotoxin type A3.4.24.690.449
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.449
4j7uYTZSepiapterin reductase1.1.1.1530.449
4x5gFOLDihydrofolate reductase1.5.1.30.449
5dp2NAPCurF/0.449
1bwlFMNNADPH dehydrogenase 11.6.99.10.448
1d6w00RProthrombin3.4.21.50.448
1fmlRTLRetinol dehydratase/0.448
1h50FMNPentaerythritol tetranitrate reductase/0.448
1jraFADFAD-linked sulfhydryl oxidase ERV21.8.3.20.448
1n3rGTPGTP cyclohydrolase 13.5.4.160.448
1r8qAFBCytohesin-2/0.448
1r8qAFBADP-ribosylation factor 1/0.448
1synF89Thymidylate synthase/0.448
1touB1VFatty acid-binding protein, adipocyte/0.448
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.448
2anmCDOProthrombin3.4.21.50.448
2e0nSAHPrecorrin-2 C20-methyltransferase/0.448
2gq3COAMalate synthase G/0.448
2jl1NAPTriphenylmethane reductase/0.448
2q1uNADPutative nucleotide sugar epimerase/ dehydratase/0.448
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.448
3br3ETHTH-type transcriptional regulator QacR/0.448
3iodA6DPantothenate synthetase6.3.2.10.448
3qviK95HAP protein/0.448
4ead0NPThymidine phosphorylase2.4.2.40.448
4f1yCNIGlutamate receptor 3/0.448
4gd40WSLysine-specific demethylase 4A1.14.110.448
4hy6FJ1Heat shock protein HSP 90-alpha/0.448
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.448
4mlp2CXCryptochrome-2/0.448
4xbaGMPAprataxin-like protein30.448
1cjkFOKAdenylate cyclase type 2/0.447
1cjkFOKAdenylate cyclase type 5/0.447
1dr3HBIDihydrofolate reductase1.5.1.30.447
1h36R88Squalene--hopene cyclase4.2.1.1290.447
1hb3SCVIsopenicillin N synthase1.21.3.10.447
2a9z26AAdenosine kinase2.7.1.200.447
2ji9TPWOxalyl-CoA decarboxylase4.1.1.80.447
2rl1UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.447
2vdyHCYCorticosteroid-binding globulin/0.447
3bk2U5PRibonuclease J/0.447
3djfBC3Purine nucleoside phosphorylase/0.447
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.447
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.447
3ix8TX3Transcriptional activator protein LasR/0.447
3mjrAC2Deoxycytidine kinase2.7.1.740.447
3qizQI2Botulinum neurotoxin type A3.4.24.690.447
4jx1CAHCamphor 5-monooxygenase1.14.15.10.447
4l5aTBNS-methyl-5'-thioadenosine phosphorylase/0.447
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.447
4yx6FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD/0.447
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.447
1k4gAIQQueuine tRNA-ribosyltransferase2.4.2.290.446
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.446
2g1n1IGRenin3.4.23.150.446
2getCOKPantothenate kinase2.7.1.330.446
2geuCOKPantothenate kinase2.7.1.330.446
2r0cFADPutative FAD-monooxygenase/0.446
2w6oOA3Biotin carboxylase6.3.4.140.446
2wueKEK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.446
2y3pSM8DNA gyrase subunit A/0.446
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.446
3ae4FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.446
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.446
3elePLPAminotransferase/0.446
3jynNDPQuinone oxidoreductase/0.446
3rgaILDEpoxide hydrolase LasB5.5.10.446
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.446
3uxvGUNNADPH-dependent 7-cyano-7-deazaguanine reductase/0.446
3v0n4GWHisto-blood group ABO system transferase/0.446
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.446
4b4vL34Bifunctional protein FolD/0.446
4jq3ZOMAldo-keto reductase family 1 member C2/0.446
4klnAGSTransitional endoplasmic reticulum ATPase3.6.4.60.446
4pb25UDNucleoside permease/0.446
4u8iFDAUDP-galactopyranose mutase/0.446
4wx2F6FTryptophan synthase alpha chain/0.446
4wx2F6FTryptophan synthase beta chain4.2.1.200.446
4xymCOAAcyl-CoA synthetase (NDP forming)/0.446
5dhhDGWNociceptin receptor/0.446
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.445
1itzTPPTransketolase, chloroplastic2.2.1.10.445
1nd52BFProstatic acid phosphatase3.1.3.20.445
1q3hANPCystic fibrosis transmembrane conductance regulator/0.445
1ygjRMCPyridoxal kinase2.7.1.350.445
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.445
2qbr910Tyrosine-protein phosphatase non-receptor type 13.1.3.480.445
2wghDTPRibonucleoside-diphosphate reductase large subunit1.17.4.10.445
3akkADPSerine/threonine-protein kinase CtkA2.7.11.10.445
3biy01KHistone acetyltransferase p300/0.445
3cr0809Wee1-like protein kinase2.7.10.20.445
3d5qT30Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.445
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.445
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
3imeBZ2Pantothenate synthetase6.3.2.10.445
3juqAJDPhenazine biosynthesis protein A/B/0.445
3nx2FERFerulic acid decarboxylase/0.445
3ogkOGKCoronatine-insensitive protein 1/0.445
3oxfSAHHistone-lysine N-methyltransferase SMYD32.1.1.430.445
3pqbVGPPutative oxidoreductase/0.445
3qfcNAPNADPH--cytochrome P450 reductase/0.445
3zkyWT4Isopenicillin N synthase1.21.3.10.445
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.445
4dya0MFNucleoprotein/0.445
4esoNAPPutative oxidoreductase/0.445
4fqsLYAThymidylate synthase ThyA/0.445
4i8vBHFCytochrome P450 1A11.14.14.10.445
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.445
4xmxBESAminopeptidase N3.4.11.20.445
4zp0DXCMultidrug transporter MdfA/0.445
1i5bANPChemotaxis protein CheA2.7.13.30.444
1kh3ANPArgininosuccinate synthase/0.444
1kvtUPGUDP-glucose 4-epimerase5.1.3.20.444
1qjfACSIsopenicillin N synthase1.21.3.10.444
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.444
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.444
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.444
1wuaAP8Actin, alpha skeletal muscle/0.444
2a2cADPN-acetylgalactosamine kinase2.7.1.1570.444
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.444
2gjnFMNNitronate monooxygenase1.13.12.160.444
2uxhQUEHTH-type transcriptional regulator TtgR/0.444
2v16C47Renin3.4.23.150.444
3a3yOBNSodium/potassium-transporting ATPase subunit alpha/0.444
3ai0PNWBeta-glucosidase/0.444
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3fgoACPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.444
3gcq1BUMitogen-activated protein kinase 14/0.444
3gwfNAPCyclohexanone monooxygenase/0.444
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.444
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.444
3qlxQLRUncharacterized protein/0.444
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.444
3uq9TBNPutative adenosine kinase/0.444
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
4bdoKAIGlutamate receptor ionotropic, kainate 2/0.444
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.444
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.444
4hnc0UTMandelate racemase/0.444
4jlj1NMDeoxycytidine kinase2.7.1.740.444
4kodADPTransitional endoplasmic reticulum ATPase3.6.4.60.444
4m4821BSodium-dependent dopamine transporter/0.444
4req5ADMethylmalonyl-CoA mutase large subunit5.4.99.20.444
4rriA3TProbable threonine--tRNA ligase 26.1.1.30.444
4zu44TGWxcM-like protein/0.444
1cjuFOKAdenylate cyclase type 2/0.443
1cjuFOKAdenylate cyclase type 5/0.443
1h65GDPTranslocase of chloroplast 343.6.50.443
1lhwESMSex hormone-binding globulin/0.443
1vrqFONSubunit alpha of sarocosine oxidase/0.443
1wuq8GTGTP cyclohydrolase 1/0.443
1x8lOXRRetinol dehydratase/0.443
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.443
2a2dANPN-acetylgalactosamine kinase2.7.1.1570.443
2bjfDXCCholoylglycine hydrolase3.5.1.240.443
2e1mFADL-glutamate oxidase/0.443
2g5w8PG12-oxophytodienoate reductase 31.3.1.420.443
2jlcTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.443
2qg2A91Heat shock protein HSP 90-alpha/0.443
2w3mFOLDihydrofolate reductase1.5.1.30.443
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.443
2xabVHDHeat shock protein HSP 90-alpha/0.443
2ym1FADPhenylacetone monooxygenase1.14.13.920.443
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.443
3adaNADSubunit alpha of sarocosine oxidase/0.443
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.443
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.443
3junAJDPhenazine biosynthesis protein A/B/0.443
3pd4A3GThreonine--tRNA ligase6.1.1.30.443
3zoiM2WIsopenicillin N synthase1.21.3.10.443
4c2jCOA3-ketoacyl-CoA thiolase, mitochondrial2.3.1.160.443
4rrkA3TProbable threonine--tRNA ligase 26.1.1.30.443
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.443
1crbRTLRetinol-binding protein 1/0.442
1dghNDPCatalase1.11.1.60.442
1g93UPGN-acetyllactosaminide alpha-1,3-galactosyltransferase/0.442
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1m9m6NINitric oxide synthase, endothelial1.14.13.390.442
1mlzPLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.442
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.442
1t90NADMalonate-semialdehyde dehydrogenase1.2.1.270.442
1tojHCIAspartate aminotransferase2.6.1.10.442
1y56FMNUncharacterized protein/0.442
1y56FMN382aa long hypothetical sarcosine oxidase/0.442
2apcUDMAlpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase2.4.1.1010.442
2e20B4PPropionate kinase/0.442
2ewaSB2Mitogen-activated protein kinase 14/0.442
2g97DGBNicotinamide phosphoribosyltransferase2.4.2.120.442
2hxzH7JCathepsin S3.4.22.270.442
2jb4A14Isopenicillin N synthase1.21.3.10.442
2pksG44Prothrombin3.4.21.50.442
2qcxPF1Aminopyrimidine aminohydrolase/0.442
3biz61EWee1-like protein kinase2.7.10.20.442
3c34KAIGlutamate receptor ionotropic, kainate 1/0.442
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.442
3p84FMNPentaerythritol tetranitrate reductase/0.442
4ap1NAPSteroid monooxygenase/0.442
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.442
4b1rITCTetracycline repressor protein class D/0.442
4du6GTPGTP cyclohydrolase 1/0.442
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4k5o1OTM1 family aminopeptidase3.4.110.442
4ku7PCGcGMP-dependent protein kinase 12.7.11.120.442
4obuPLPPyridoxal-dependent decarboxylase domain protein/0.442
4yaf2AMNADPH--cytochrome P450 reductase/0.442
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.442
1djqFMNTrimethylamine dehydrogenase1.5.8.20.441
1ej2NADNicotinamide-nucleotide adenylyltransferase2.7.7.10.441
1esmCOAPantothenate kinase2.7.1.330.441
1kf6FADFumarate reductase flavoprotein subunit1.3.5.40.441
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.441
1u0hFOKAdenylate cyclase type 2/0.441
1u0hFOKAdenylate cyclase type 5/0.441
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.441
1x7b041Estrogen receptor beta/0.441
2aqbTL63-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.441
2ej2PPEBranched-chain amino acid aminotransferase (IlvE)/0.441
2fjeFADAdenylylsulfate reductase, subunit A (AprA)/0.441
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.441
2lbaCHOFatty acid binding protein 6/0.441
2oliIOPBasic phospholipase A2 VRV-PL-VIIIa3.1.1.40.441
2qo9ANPEphrin type-A receptor 32.7.10.10.441
2uxoTACHTH-type transcriptional regulator TtgR/0.441
2zevB71Geranylgeranyl pyrophosphate synthase/0.441
3anmSYD1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.441
3f63GTXGlutathione transferase GST1-4/0.441
3fp0FP015-O-acetyltransferase/0.441
3h06VBPGlutamate receptor 2/0.441
3jusBCDLanosterol 14-alpha demethylase1.14.13.700.441
3mnrSD1Heat shock protein HSP 90-alpha/0.441
3p74FMNPentaerythritol tetranitrate reductase/0.441
3rdqDTBStreptavidin/0.441
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
4aosNAPSteroid monooxygenase/0.441
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.441
4fvz4KJNitric oxide synthase, brain1.14.13.390.441
4jxrACOAcetyltransferase/0.441
4mv4ACPBiotin carboxylase6.3.4.140.441
4psbGA3Cytokinin-specific binding protein/0.441
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.441
5fm6ADPRuvB-like helicase/0.441
5jy1NADPutative short-chain dehydrogenase/reductase/0.441
1bsvNDPGDP-L-fucose synthase/0.440
1gky5GPGuanylate kinase2.7.4.80.440
1mvsDTMDihydrofolate reductase1.5.1.30.440
1nbmADPATP synthase subunit beta, mitochondrial3.6.3.140.440
1pu9COAHAT A1/0.440
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.440
1ykdCMPAdenylate cyclase/0.440
2am22LGUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.440
2clfF6FTryptophan synthase alpha chain/0.440
2jfhLK1UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
2x3jATPAcsD/0.440
2yejXQKHeat shock protein HSP 90-alpha/0.440
2yyeAPCSelenide, water dikinase2.7.9.30.440
2zrzFNRIsopentenyl-diphosphate delta-isomerase/0.440
2zxgS23Aminopeptidase N3.4.11.20.440
3eblGA4Gibberellin receptor GID1/0.440
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.440
3fywXCFDihydrofolate reductase1.5.1.30.440
3g72A6TRenin3.4.23.150.440
3h3t16HCollagen type IV alpha-3-binding protein/0.440
3kc02T5Fructose-1,6-bisphosphatase 13.1.3.110.440
3nxtD2EDihydrofolate reductase1.5.1.30.440
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.440
3tydXHPDihydropteroate synthase/0.440
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.440
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.440
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4cdmFO1Deoxyribodipyrimidine photolyase/0.440
4elh53IDihydrofolate reductase/0.440
4lgaA2OAbscisic acid receptor PYL2/0.440
4o8aFADBifunctional protein PutA1.2.1.880.440
5cpmFNRNADH:flavin oxidoreductase/0.440
4zj8SUVOrexin receptor type 1/0.440