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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1mqbANPEphrin type-A receptor 22.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1mqbANPEphrin type-A receptor 22.7.10.11.000
2henADPEphrin type-B receptor 22.7.10.10.553
2qoqANPEphrin type-A receptor 32.7.10.10.550
3zewSTUEphrin type-B receptor 42.7.10.10.518
2qo7ANPEphrin type-A receptor 32.7.10.10.517
2xvdAS6Ephrin type-B receptor 42.7.10.10.515
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.515
2ijmATPFocal adhesion kinase 12.7.10.20.510
4j99ACPFibroblast growth factor receptor 2/0.504
4jia1K3Tyrosine-protein kinase JAK2/0.502
4gk4L90Ephrin type-A receptor 32.7.10.10.501
3a7hATPSerine/threonine-protein kinase 242.7.11.10.499
4c3pACPAurora kinase A2.7.11.10.498
4qmlANPSerine/threonine-protein kinase 242.7.11.10.497
4j95ACPFibroblast growth factor receptor 2/0.495
2vwu7X1Ephrin type-B receptor 42.7.10.10.494
2v7a627Tyrosine-protein kinase ABL12.7.10.20.487
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.487
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.487
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.484
3d7tSTUTyrosine-protein kinase CSK/0.484
2j0lANPFocal adhesion kinase 12.7.10.20.483
2j0m4STFocal adhesion kinase 12.7.10.20.483
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.483
3t8oATPRhodopsin kinase/0.481
2ijmADPFocal adhesion kinase 12.7.10.20.480
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.477
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.476
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.474
4gmy0X5Tyrosine-protein kinase JAK2/0.474
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.470
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.470
3vjoANPEpidermal growth factor receptor2.7.10.10.469
2etm7PYFocal adhesion kinase 12.7.10.20.468
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.468
1bygSTUTyrosine-protein kinase CSK/0.467
2wqeADPAurora kinase A2.7.11.10.466
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.466
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.466
2ojj82AMitogen-activated protein kinase 12.7.11.240.465
4qo9627Serine/threonine-protein kinase 242.7.11.10.464
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.463
4aguD15Cyclin-dependent kinase-like 1/0.463
1i44ACPInsulin receptor2.7.10.10.462
3w2o03PEpidermal growth factor receptor2.7.10.10.461
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.460
2qocANPEphrin type-A receptor 32.7.10.10.460
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
3c4xATPRhodopsin kinase/0.459
3lpbNVBTyrosine-protein kinase JAK2/0.459
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.458
2qo9ANPEphrin type-A receptor 32.7.10.10.458
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.457
4gk2L66Ephrin type-A receptor 32.7.10.10.456
4gk3L87Ephrin type-A receptor 32.7.10.10.456
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.454
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.454
4ji91M3Tyrosine-protein kinase JAK2/0.454
2of2547Tyrosine-protein kinase Lck2.7.10.20.453
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.453
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
2j7t274Serine/threonine-protein kinase 102.7.11.10.452
2yn8STUEphrin type-B receptor 42.7.10.10.452
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4o0uADNAurora kinase A2.7.11.10.451
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
5l8lADPAurora kinase A2.7.11.10.450
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.449
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.448
1u54ACPActivated CDC42 kinase 1/0.447
2itvANPEpidermal growth factor receptor2.7.10.10.447
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.447
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.447
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.447
1yvj4STTyrosine-protein kinase JAK32.7.10.20.446
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.446
2x9fX9FEphrin type-B receptor 42.7.10.10.445
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.445
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.445
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.445
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.444
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.444
4g2fC07Ephrin type-A receptor 32.7.10.10.444
2hog710Serine/threonine-protein kinase Chk12.7.11.10.443
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.443
3w0nANPHygromycin-B 4-O-kinase2.7.1.1630.443
2hk51BMTyrosine-protein kinase HCK2.7.10.20.442
2pwlACPFibroblast growth factor receptor 2/0.442
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.442
2xp2VGHALK tyrosine kinase receptor2.7.10.10.442
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.442
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.441
2of4979Tyrosine-protein kinase Lck2.7.10.20.441
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.441
3c4wATPRhodopsin kinase/0.441
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.441
5aaaVGHALK tyrosine kinase receptor2.7.10.10.441
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.440
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.440
4eooATPCyclin-dependent kinase 22.7.11.220.440
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.440