sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1mmk | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1mmk | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 1.000 | |
| 1kw0 | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.639 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.518 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.517 | |
| 3v2u | ATP | Protein GAL3 | / | 0.515 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.514 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.507 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.505 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.502 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.502 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.502 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.501 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.500 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.499 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.499 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.499 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.497 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.497 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.496 | |
| 1dmw | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.494 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.490 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.490 | |
| 3int | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.489 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.488 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.487 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.487 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.487 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.487 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.486 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.485 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.485 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.484 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.482 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.481 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.481 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.480 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.480 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.479 | |
| 2aba | STR | Pentaerythritol tetranitrate reductase | / | 0.479 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.479 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.478 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.477 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.477 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.477 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.477 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.477 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.476 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.476 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.476 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.476 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.476 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.476 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.476 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.475 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.475 | |
| 2cwf | NDP | Delta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase | / | 0.475 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.474 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.474 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.474 | |
| 3wag | TYD | Glycosyltransferase | / | 0.474 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.474 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.473 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.472 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.472 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.472 | |
| 3t85 | SG7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.472 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.472 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.471 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.471 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.471 | |
| 4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.470 | |
| 2o8j | SAH | Histone-lysine N-methyltransferase EHMT2 | / | 0.469 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.469 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.468 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.468 | |
| 3rz8 | RZ8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.468 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.468 | |
| 1c7o | PPG | Hemolysin | / | 0.467 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.467 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.467 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.467 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.467 | |
| 5hq8 | SAH | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.467 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.466 | |
| 1umk | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.466 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.466 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.466 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.465 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.465 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.465 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.465 | |
| 4k9h | 1QU | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 5jin | SAM | Histone-lysine N-methyltransferase EHMT2 | / | 0.465 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.464 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.464 | |
| 3ioe | A7D | Pantothenate synthetase | 6.3.2.1 | 0.464 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.464 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.464 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.464 | |
| 4pzr | COA | Histone acetyltransferase p300 | / | 0.464 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.464 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.463 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.463 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.463 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.463 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.463 | |
| 1a9s | NOS | Purine nucleoside phosphorylase | 2.4.2.1 | 0.462 | |
| 1j8u | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.462 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.462 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.462 | |
| 3coz | 54H | Pantothenate synthetase | 6.3.2.1 | 0.462 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.462 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.462 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 4ca6 | 3EF | Angiotensin-converting enzyme | 3.2.1 | 0.462 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 2z95 | NDP | GDP-mannose 4,6-dehydratase | / | 0.461 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.461 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.461 | |
| 3vg1 | 0GT | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.461 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.461 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 1n2h | PAJ | Pantothenate synthetase | 6.3.2.1 | 0.460 | |
| 1s63 | 778 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.460 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.460 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.460 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.460 | |
| 3swc | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.460 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.459 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.459 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.459 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.459 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.459 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.459 | |
| 4nv1 | 4TG | Formyl transferase | / | 0.459 | |
| 1lc3 | NAD | Biliverdin reductase A | 1.3.1.24 | 0.458 | |
| 1pvg | ANP | DNA topoisomerase 2 | 5.99.1.3 | 0.458 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.458 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.458 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.458 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.457 | |
| 1mxf | MTX | Putative pteridine reductase 2 | / | 0.457 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.457 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.457 | |
| 2x3j | ATP | AcsD | / | 0.457 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.457 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.457 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.457 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.456 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.456 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.456 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.456 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.456 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.456 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.456 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 4ike | ADP | Adenylate kinase | / | 0.456 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.456 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.456 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1n2i | PAJ | Pantothenate synthetase | 6.3.2.1 | 0.455 | |
| 1xh8 | R55 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.455 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.455 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.455 | |
| 4mx1 | 1MX | Ricin | 3.2.2.22 | 0.455 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.455 | |
| 1knr | FAD | L-aspartate oxidase | 1.4.3.16 | 0.454 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.454 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.454 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.454 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.454 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.453 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.453 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.453 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.453 | |
| 2gs9 | SAH | Uncharacterized protein | / | 0.453 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.453 | |
| 3c36 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.453 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 3m40 | J45 | Carbonic anhydrase 2 | 4.2.1.1 | 0.453 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.453 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.453 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.453 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.453 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.453 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.453 | |
| 1xwf | ADN | Adenosylhomocysteinase | 3.3.1.1 | 0.452 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.452 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.452 | |
| 3f8w | ADN | Purine nucleoside phosphorylase | / | 0.452 | |
| 3fpd | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.452 | |
| 5jhn | SAM | Histone-lysine N-methyltransferase EHMT2 | / | 0.452 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.451 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.451 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.451 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.451 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.451 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.451 | |
| 3ojw | FMN | NADPH--cytochrome P450 reductase | / | 0.451 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.451 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.451 | |
| 4h9t | HL4 | Phosphotriesterase | / | 0.451 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.451 | |
| 4x7v | MIV | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.451 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.450 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2xtk | AZM | Class III chitinase ChiA1 | / | 0.450 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.450 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.450 | |
| 3mvz | BHN | Nickel-binding periplasmic protein | / | 0.450 | |
| 3myt | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.450 | |
| 3mzt | TFX | Beta-2-microglobulin | / | 0.450 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.450 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.450 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.450 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.450 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.450 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.449 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.449 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.449 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.449 | |
| 1n4q | LYS_CYS_VAL_ILE_LEU | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.449 | |
| 1o86 | LPR | Angiotensin-converting enzyme | 3.2.1 | 0.449 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.449 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 1vf2 | GTX | Glutathione S-transferase 3 | 2.5.1.18 | 0.449 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.449 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.449 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.449 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.449 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.449 | |
| 4fiz | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.449 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1amo | FMN | NADPH--cytochrome P450 reductase | / | 0.448 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.448 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.448 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.448 | |
| 2ym2 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.448 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3eks | CY9 | Actin-5C | / | 0.448 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.448 | |
| 3uko | NAD | Alcohol dehydrogenase class-3 | / | 0.448 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.448 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.448 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.448 | |
| 4k8s | 1QT | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4kc2 | WS2 | Histo-blood group ABO system transferase | / | 0.448 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.448 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.448 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.447 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.447 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.447 | |
| 2anb | 5GP | Guanylate kinase | 2.7.4.8 | 0.447 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.447 | |
| 2o6h | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | 2.5.1.78 | 0.447 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.447 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.447 | |
| 3i28 | 34N | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.447 | |
| 3ivx | FG6 | Pantothenate synthetase | 6.3.2.1 | 0.447 | |
| 3m98 | E02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.447 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.447 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.447 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.447 | |
| 3udq | 09E | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.447 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.447 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.447 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.447 | |
| 4e2y | JHZ | Methyltransferase | / | 0.447 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.447 | |
| 4nv0 | MG7 | 7-methylguanosine phosphate-specific 5'-nucleotidase | / | 0.447 | |
| 5a01 | 12V | O-glycosyltransferase | / | 0.447 | |
| 5jj0 | SAM | Histone-lysine N-methyltransferase EHMT2 | / | 0.447 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.447 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.446 | |
| 1ja1 | FMN | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.446 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.446 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.446 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.446 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.446 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.446 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.446 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.446 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.446 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.446 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.446 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4rrh | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.446 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.446 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.445 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.445 | |
| 1vhz | APR | ADP compounds hydrolase NudE | 3.6.1 | 0.445 | |
| 1xag | NAD | 3-dehydroquinate synthase | / | 0.445 | |
| 2bi4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.445 | |
| 2bxo | OPB | Serum albumin | / | 0.445 | |
| 2fjd | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.445 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.445 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 3m2n | J74 | Carbonic anhydrase 2 | 4.2.1.1 | 0.445 | |
| 3uov | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.445 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.445 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.445 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.445 | |
| 4zob | LGC | Lin1840 protein | / | 0.445 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.445 | |
| 1a9p | 9DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.444 | |
| 1je1 | GMP | Purine nucleoside phosphorylase | / | 0.444 | |
| 1knp | FAD | L-aspartate oxidase | 1.4.3.16 | 0.444 | |
| 1pag | FMP | Antiviral protein I | 3.2.2.22 | 0.444 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1yqs | BSA | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.444 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.444 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.444 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.444 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2ohj | FMN | Type A flavoprotein FprA | 1 | 0.444 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.444 | |
| 2vet | UMP | Thymidylate synthase | / | 0.444 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.444 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.444 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.444 | |
| 3b05 | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.444 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.444 | |
| 3m5e | JDR | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.444 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.444 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3ryk | TYD | dTDP-4-dehydrorhamnose 3,5-epimerase | / | 0.444 | |
| 4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.444 | |
| 4qfx | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.444 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.443 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.443 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.443 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.443 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.443 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.443 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.443 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.443 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3k8o | 229 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.443 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.443 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.443 | |
| 4lay | I63 | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.443 | |
| 4lxl | PD2 | Lysine-specific demethylase 4B | 1.14.11 | 0.443 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.443 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.443 | |
| 1az2 | NAP | Aldose reductase | 1.1.1.21 | 0.442 | |
| 1lrm | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.442 | |
| 1n95 | FTH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.442 | |
| 1s0j | MUS | Trans-sialidase | / | 0.442 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.442 | |
| 1xdu | SFG | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.442 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.442 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.442 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3gnv | XNZ | Genome polyprotein | 2.7.7.48 | 0.442 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.442 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.442 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.442 | |
| 4kc4 | WS3 | Histo-blood group ABO system transferase | / | 0.442 | |
| 1e2n | RCA | Thymidine kinase | / | 0.441 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.441 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.441 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.441 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.441 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.441 | |
| 2ydb | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 3kjg | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.441 | |
| 3w3l | RX8 | Toll-like receptor 8 | / | 0.441 | |
| 4dyp | 0MS | Nucleoprotein | / | 0.441 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.441 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.441 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.441 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.441 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.440 | |
| 1jdt | MTA | Purine nucleoside phosphorylase | / | 0.440 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.440 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.440 | |
| 2qn3 | F55 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.440 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.440 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.440 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.440 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.440 | |
| 3qfr | FMN | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.440 | |
| 4j7g | TRH | PCZA361.3 | / | 0.440 | |
| 4kl1 | PCG | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.440 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.440 | |
| 5ftc | ADP | TPR domain protein | / | 0.440 | |
| 5hwp | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.440 |