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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1mg5NAIAlcohol dehydrogenase1.1.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1mg5NAIAlcohol dehydrogenase1.1.1.11.000
3rj5NADAlcohol dehydrogenase1.1.1.10.617
1b16NAQAlcohol dehydrogenase1.1.1.10.608
3rj9NADAlcohol dehydrogenase1.1.1.10.603
1b15NAEAlcohol dehydrogenase1.1.1.10.593
5jlaNADPutative short-chain dehydrogenase/reductase/0.593
1sbyNADAlcohol dehydrogenase1.1.1.10.587
1b14NADAlcohol dehydrogenase1.1.1.10.579
3a4vNADNDP-sugar epimerase/0.572
4gh5NADShort-chain dehydrogenase/reductase SDR/0.572
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.565
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.563
3ak4NADNADH-dependent quinuclidinone reductase/0.562
1pr9NAPL-xylulose reductase1.1.1.100.558
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.555
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.553
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.552
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.550
3a1nNADNDP-sugar epimerase/0.550
1iy8NADLevodione reductase/0.547
1wntNAPL-xylulose reductase1.1.1.100.547
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.545
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.542
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.541
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.541
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.538
2p5uNADUDP-glucose 4-epimerase/0.535
2dteNAIGlucose 1-dehydrogenase related protein/0.534
2wsbNADGalactitol dehydrogenase/0.534
3wdsNADNADH-dependent quinuclidinone reductase/0.534
1w4zNAPPutative ketoacyl reductase1.3.10.533
3w8dNAD3-hydroxybutyrate dehydrogenase/0.533
3wmxNADNAD dependent epimerase/dehydratase/0.533
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.531
2yy7NADL-threonine dehydrogenase/0.531
3uxyNADShort-chain dehydrogenase/reductase SDR/0.531
2wdzNADGalactitol dehydrogenase/0.529
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.529
4yagNAIC alpha-dehydrogenase/0.528
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.526
4yaiNAIC alpha-dehydrogenase/0.525
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.524
4dc1NDPPutative ketoacyl reductase1.3.10.522
1ipeNDPTropinone reductase 21.1.1.2360.521
3w8fNAD3-hydroxybutyrate dehydrogenase/0.521
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.520
3gy0NAPNAD(P)-dependent oxidoreductase/0.520
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.520
5lc1NADL-threonine 3-dehydrogenase/0.519
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.517
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.516
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.515
4fn4NADShort chain dehydrogenase/0.515
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.514
3w8eNAD3-hydroxybutyrate dehydrogenase/0.513
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.512
4qecNAPElxO/0.512
1kvrNADUDP-glucose 4-epimerase5.1.3.20.511
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.511
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.511
3qrwNDPPutative ketoacyl reductase1.3.10.508
3toxNAPPutative oxidoreductase/0.508
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.507
3sx2NADUncharacterized protein/0.506
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.505
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.504
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.504
1x7hNDPPutative ketoacyl reductase1.3.10.501
2yutNAPPutative short-chain oxidoreductase/0.500
3p19NDPPutative blue fluorescent protein/0.500
1zemNADXylitol dehydrogenase/0.499
1ae1NAPTropinone reductase 1/0.497
1nahNADUDP-glucose 4-epimerase5.1.3.20.497
1snyNAPLD36273p/0.497
2bd0NAPSepiapterin reductase/0.497
5ig2NADShort-chain dehydrogenase/reductase SDR/0.497
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.496
1x7gNAPPutative ketoacyl reductase1.3.10.495
3d3wNAPL-xylulose reductase1.1.1.100.495
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.495
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.494
3ajrNADNDP-sugar epimerase/0.494
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.494
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.493
3ggoNAIPrephenate dehydrogenase/0.493
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.493
2x6tNAPADP-L-glycero-D-manno-heptose-6-epimerase/0.491
3aw9NADNAD-dependent epimerase/dehydratase/0.491
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.491
3vdqNAD3-hydroxybutyrate dehydrogenase/0.490
5idwNAPShort-chain dehydrogenase/reductase SDR/0.490
4impNDPPolyketide synthase extender modules 3-4/0.489
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.488
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.488
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.487
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.487
1g1aNADdTDP-glucose 4,6-dehydratase/0.486
3r3sNADPutative oxidoreductase/0.486
4hwkNAPSepiapterin reductase1.1.1.1530.486
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.486
4qedNAPElxO/0.486
1n5dNDPCarbonyl reductase [NADPH] 1/0.485
2hjrAPRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase/0.485
2x86NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.485
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.485
4oknNAIL-lactate dehydrogenase A chain1.1.1.270.484
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.483
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.483
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.482
3s55NADPutative short-chain dehydrogenase/reductase/0.482
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.481
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.480
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.480
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.479
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.479
2jahNDPClavaldehyde dehydrogenase/0.478
3sjuNDPKeto reductase/0.478
5jydNADShort chain dehydrogenase/0.478
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.477
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.477
1h7wFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.476
1i3lNADUDP-glucose 4-epimerase/0.476
1ie3NADMalate dehydrogenase/0.476
1xkqNDPUncharacterized protein/0.476
3tscNADUncharacterized protein/0.476
4j7uNAPSepiapterin reductase1.1.1.1530.476
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.476
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.475
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.475
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.475
3ru7NADUDP-N-acetylglucosamine 4-epimerase/0.473
3uceNDPDehydrogenase/0.473
4egbNADdTDP-glucose 4,6-dehydratase/0.473
1geeNADGlucose 1-dehydrogenase1.1.1.470.472
3lqfNADGalactitol dehydrogenase/0.472
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.472
4nbwNADShort-chain dehydrogenase/reductase SDR/0.472
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.471
1i2bNADUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.470
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.470
1ybaNADD-3-phosphoglycerate dehydrogenase1.1.1.950.469
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.469
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.469
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.468
1xg5NAPDehydrogenase/reductase SDR family member 11/0.467
2aa3AP0L-lactate dehydrogenase/0.467
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.467
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.466
3f1kNAPUncharacterized oxidoreductase YciK10.466
1pzgA3DLactate dehydrogenase/0.465
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.465
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.465
1sowNADL-lactate dehydrogenase1.1.1.270.464
3hjaNADGlyceraldehyde-3-phosphate dehydrogenase/0.464
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.463
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.462
2a92NAIL-lactate dehydrogenase/0.462
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.462
4j7xNAPSepiapterin reductase1.1.1.1530.462
3a9wNADNDP-sugar epimerase/0.461
3l77NJPShort-chain alcohol dehydrogenase/0.461
1z7eATPBifunctional polymyxin resistance protein ArnA/0.460
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.459
1fy7COAHistone acetyltransferase ESA1/0.459
1n7hNDPGDP-mannose 4,6 dehydratase 24.2.1.470.459
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.459
3ruhNADUDP-N-acetylglucosamine 4-epimerase/0.459
1yqxNAPSinapyl alcohol dehydrogenase/0.458
1rwbNADGlucose 1-dehydrogenase1.1.1.470.456
4wluNADMalate dehydrogenase, mitochondrial1.1.1.370.455
3sxpNADADP-L-glycero-D-mannoheptose-6-epimerase/0.454
4ajp88NL-lactate dehydrogenase A chain1.1.1.270.453
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.452
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.452
1mjbACOHistone acetyltransferase ESA1/0.452
1rkxNADCDP-D-glucose-4,6-dehydratase/0.452
2gsdNADFormate dehydrogenase/0.452
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.452
1gcoNADGlucose 1-dehydrogenase1.1.1.470.451
1t2dNADL-lactate dehydrogenase1.1.1.270.451
1yb5NAPQuinone oxidoreductase1.6.5.50.451
2q4bNAPUncharacterized protein At5g02240/0.451
3tn7NJPShort-chain alcohol dehydrogenase/0.451
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.451
5jy1NADPutative short-chain dehydrogenase/reductase/0.451
1naiNADUDP-glucose 4-epimerase5.1.3.20.450
1oaaNAPSepiapterin reductase1.1.1.1530.450
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.450
4e5yNDPGDP-L-fucose synthase1.1.1.2710.450
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
1pzfA3DLactate dehydrogenase/0.448
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
2pa3NAID-3-phosphoglycerate dehydrogenase1.1.1.950.448
2y0mACOHistone acetyltransferase KAT8/0.447
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.446
4b79NADProbable short-chain dehydrogenase/0.446
5mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.446
4b8wNAPGDP-L-fucose synthase1.1.1.2710.445
4bmvNAPShort-chain dehydrogenase/0.445
4lcjNADC-terminal-binding protein 2/0.445
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.445
4wlvNADMalate dehydrogenase, mitochondrial1.1.1.370.445
2fzeAPRAlcohol dehydrogenase class-31.1.1.10.444
2gn8NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.444
3cmcNADGlyceraldehyde-3-phosphate dehydrogenase/0.444
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.443
3rueNADUDP-N-acetylglucosamine 4-epimerase/0.443
4q71FADBifunctional protein PutA/0.443
4gkvNADAlcohol dehydrogenase, propanol-preferring1.1.1.10.442
4o1mNADEnoyl-acyl carrier reductase/0.442
1mj9COAHistone acetyltransferase ESA1/0.441
3ai3NDPNADPH-sorbose reductase/0.441
3ruaNADUDP-N-acetylglucosamine 4-epimerase/0.441
2xaaNADSecondary alcohol dehydrogenase/0.440