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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1meiXMPInosine-5'-monophosphate dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1meiXMPInosine-5'-monophosphate dehydrogenase/1.000
1meiMOAInosine-5'-monophosphate dehydrogenase/0.688
1me7RVPInosine-5'-monophosphate dehydrogenase/0.679
1me8RVPInosine-5'-monophosphate dehydrogenase/0.620
1me7MOAInosine-5'-monophosphate dehydrogenase/0.526
2cu0XMPInosine-5'-monophosphate dehydrogenase/0.504
4z0g5GPInosine-5'-monophosphate dehydrogenase/0.501
1nf7RVPInosine-5'-monophosphate dehydrogenase 2/0.500
4z875GPInosine-5'-monophosphate dehydrogenase/0.487
2a7r5GPGMP reductase 2/0.477
4qq3XMPInosine-5'-monophosphate dehydrogenase/0.468
2a1y5GPGMP reductase/0.460
3h06VBPGlutamate receptor 2/0.456
2qn7HBZGlycogen phosphorylase, muscle form2.4.1.10.453
2gjlFMNNitronate monooxygenase1.13.12.160.450
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.450
1iy8NADLevodione reductase/0.448
1xkdNAPIsocitrate dehydrogenase [NADP]/0.446
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.445
1k6cMK1Gag-Pol polyprotein3.4.23.160.444
4kx6FADFumarate reductase flavoprotein subunit1.3.5.40.444
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
1mg5NAIAlcohol dehydrogenase1.1.1.10.440