sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1m51 | TSX | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1m51 | TSX | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 1.000 | |
| 1khe | GCP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.626 | |
| 1khb | GCP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.570 | |
| 3moh | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.557 | |
| 4wpu | GDP | Phosphoenolpyruvate carboxykinase [GTP] | / | 0.550 | |
| 2qf2 | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.522 | |
| 3dt4 | GTP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.503 | |
| 5i67 | GDP | Phosphoenolpyruvate carboxykinase [GTP] | / | 0.492 | |
| 2fah | GDP | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial | 4.1.1.32 | 0.487 | |
| 3dt2 | GTP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.483 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.461 | |
| 4fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.453 | |
| 4fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.453 | |
| 4r43 | GDP | Phosphoenolpyruvate carboxykinase [GTP] | / | 0.453 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.453 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.451 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
| 5doz | NDP | JamJ | / | 0.449 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.448 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.447 | |
| 2rh1 | CAU | Beta-2 adrenergic receptor | / | 0.447 | |
| 2vqs | BVD | Deoxynucleoside kinase | / | 0.446 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.446 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.445 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 5f54 | TMP | Single-stranded-DNA-specific exonuclease | / | 0.442 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.441 | |
| 1ypj | UIB | Prothrombin | 3.4.21.5 | 0.441 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2i8c | ADP | D-alanine--D-alanine ligase | / | 0.441 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 |