Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1l8aTDPPyruvate dehydrogenase E1 component1.2.4.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1l8aTDPPyruvate dehydrogenase E1 component1.2.4.11.000
2qtcTDKPyruvate dehydrogenase E1 component1.2.4.10.694
2qtaTDPPyruvate dehydrogenase E1 component1.2.4.10.624
1rp7TZDPyruvate dehydrogenase E1 component1.2.4.10.613
2ieaTDPPyruvate dehydrogenase E1 component1.2.4.10.599
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.551
3lq4TDPPyruvate dehydrogenase E1 component1.2.4.10.543
1ay0TPPTransketolase 12.2.1.10.481
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.481
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.10.447