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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1kmqGNPTransforming protein RhoA

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1kmqGNPTransforming protein RhoA/1.000
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.612
1cxzGSPTransforming protein RhoA/0.603
2gcpGSPRho-related GTP-binding protein RhoC/0.594
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.593
1a2bGSPTransforming protein RhoA/0.588
1s1cGNPTransforming protein RhoA/0.574
3kz1GSPTransforming protein RhoA/0.573
4xoiGTPTransforming protein RhoA/0.573
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.569
4js0GNPCell division control protein 42 homolog/0.564
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.556
3a58GNPGTP-binding protein RHO1/0.556
3eg5GNPCell division control protein 42 homolog/0.555
1m7bGTPRho-related GTP-binding protein RhoE/0.553
5dhaGNPGTP-binding nuclear protein Ran/0.553
4nyiGNPGTPase HRas/0.551
1g17GNPRas-related protein SEC4/0.547
5hpyGDPTransforming protein RhoA/0.543
3e5hGNPRas-related protein Rab-28/0.537
1xtsGTPGTP-binding protein Rheb/0.533
3tnfGNPRas-related protein Rab-8A/0.527
4nyjGNPGTPase HRas/0.524
1zbdGTPRas-related protein Rab-3A/0.522
4dltGNPGTPase HRas/0.522
1t91GTPRas-related protein Rab-7a/0.521
1xtrGNPGTP-binding protein Rheb/0.521
3th5GNPRas-related C3 botulinum toxin substrate 1/0.521
3lawGNPRas-related protein Rab-7a/0.520
3bbpGTPRas-related protein Rab-6A/0.518
3oesGNPGTPase RhebL1/0.518
1yhnGTPRas-related protein Rab-7a/0.517
4qxaGTPRas-related protein Rab-9A/0.517
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.516
2gilGTPRas-related protein Rab-6A/0.515
3kucGDPRas-related protein Rap-1A/0.514
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.513
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.511
3bc1GNPRas-related protein Rab-27A/0.510
4mitGTPRho-related protein racC/0.510
2zetGTPRas-related protein Rab-27B/0.509
1e96GTPRas-related C3 botulinum toxin substrate 1/0.508
3lbnGNPGTPase HRas/0.507
4cymGCPRas-related protein Rab-32/0.507
1gwnGTPRho-related GTP-binding protein RhoE/0.506
1zc4GNPRas-related protein Ral-A/0.504
3rabGNPRas-related protein Rab-3A/0.504
3tgpGNPGTPase HRas/0.504
3oiuGNPGTPase HRas/0.501
4o25GTPGTP-binding protein Rheb/0.501
1yzqGNPRas-related protein Rab-6A/0.500
3nbzGTPGTP-binding nuclear protein Ran/0.500
3ddcGNPGTPase HRas/0.498
1vg8GNPRas-related protein Rab-7a/0.497
2ffqGSPRas-related protein Rab-6B/0.497
3w3zGTPGTP-binding nuclear protein Ran/0.497
1z2cGNPRho-related GTP-binding protein RhoC/0.496
1zc3GNPRas-related protein Ral-A/0.495
3tsoGNPRas-related protein Rab-25/0.492
4kvgGTPRas-related protein Rap-1A/0.492
3v4fGNPGTPase HRas/0.491
3kkoGNPRas-related protein M-Ras/0.489
5jljGNPGTP-binding nuclear protein Ran/0.488
2clsGTPRho-related GTP-binding protein Rho6/0.486
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.486
4lhwGNPRas-related protein Rab-8A/0.484
3a6pGTPGTP-binding nuclear protein Ran/0.483
3i3sGNPGTPase HRas/0.483
2fe4GDPRas-related protein Rab-6B/0.481
2c5lGTPGTPase HRas/0.478
1lfdGNPGTPase HRas/0.476
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.476
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.473
3oivGNPGTPase HRas/0.471
5b2zGNPGTPase HRas/0.471
4dsnGCPGTPase KRas/0.470
4k81GTPGTPase HRas/0.470
3qbtGNPRas-related protein Rab-8A/0.469
1ow3GDPTransforming protein RhoA/0.468
1uadGNPRas-related protein Ral-A/0.468
2cl6CAGGTPase HRas/0.468
4rkfGNPRas-related protein Rab-3/0.468
2bkuGTPGTP-binding nuclear protein Ran/0.465
1ibrGNPGTP-binding nuclear protein Ran/0.460
4dsoGSPGTPase KRas/0.460
2rgcGNPGTPase HRas/0.459
2rgeGNPGTPase HRas/0.459
3kudGDPGTPase HRas/0.458
4dlwGNPGTPase HRas/0.457
3rs5GNPGTPase HRas/0.456
4dvgGSPRho family GTPase/0.455
2rggGNPGTPase HRas/0.453
3lbhGNPGTPase HRas/0.453
3tklGTPRas-related protein Rab-1A/0.453
3pitGNPRas-related protein M-Ras/0.452
3l8yGNPGTPase HRas/0.451
1z0aGDPRas-related protein Rab-2A/0.450
3ea5GDPGTP-binding nuclear protein Ran/0.449
3lbiGNPGTPase HRas/0.447
4g0nGNPGTPase HRas/0.447
4xvrGNPGTPase HRas/0.446
1oixGDPRas-related protein Rab-11A/0.445
4ol0GTPGTP-binding nuclear protein Ran/0.444
1ay0TPPTransketolase 12.2.1.10.443
1k5dGNPGTP-binding nuclear protein Ran/0.443
3rs7GNPGTPase HRas/0.441
3cphGDPRas-related protein SEC4/0.440
3rs4GNPGTPase HRas/0.440