sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1kfj | PLS | Tryptophan synthase beta chain | 4.2.1.20 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1kfj | PLS | Tryptophan synthase beta chain | 4.2.1.20 | 1.000 | |
| 2clo | PLS | Tryptophan synthase beta chain | 4.2.1.20 | 0.623 | |
| 5dw0 | PLS | Tryptophan synthase beta chain 1 | 4.2.1.20 | 0.621 | |
| 2trs | PLS | Tryptophan synthase beta chain | 4.2.1.20 | 0.512 | |
| 2tys | PLT | Tryptophan synthase beta chain | 4.2.1.20 | 0.475 | |
| 1jed | ADP | Sulfate adenylyltransferase | / | 0.472 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.470 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.466 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.465 | |
| 2qoc | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.464 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.461 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.461 | |
| 4eeu | FMN | Phototropin-2 | 2.7.11.1 | 0.460 | |
| 2qoq | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.458 | |
| 2yvw | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.458 | |
| 3w8r | ACP | Uridine kinase | / | 0.458 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.457 | |
| 4ffr | ATP | Uncharacterized protein | / | 0.456 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.455 | |
| 5dst | SAH | Protein arginine N-methyltransferase 8 | 2.1.1 | 0.455 | |
| 2vwh | NAP | Glucose 1-dehydrogenase | / | 0.452 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4okn | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.451 | |
| 2npx | FAD | NADH peroxidase | 1.11.1.1 | 0.450 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.450 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.449 | |
| 3o15 | 3NM | Thiamine-phosphate synthase | / | 0.449 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.449 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.448 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.447 | |
| 3r1r | ATP | Ribonucleoside-diphosphate reductase 1 subunit alpha | 1.17.4.1 | 0.447 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.447 | |
| 1tvo | FRZ | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.446 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.446 | |
| 2pmo | HMD | Protein kinase 7 | / | 0.446 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.446 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.445 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.445 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.444 | |
| 4u03 | GTP | Cyclic GMP-AMP synthase | / | 0.444 | |
| 2qo7 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.443 | |
| 1rdw | LAR | Actin, alpha skeletal muscle | / | 0.442 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.442 | |
| 3clu | FAD | Electron transfer flavoprotein subunit alpha | / | 0.442 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.442 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.442 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.442 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.442 | |
| 1dj2 | GDP | Adenylosuccinate synthetase, chloroplastic | / | 0.441 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.441 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3rn8 | RN8 | Glutamate receptor 2 | / | 0.441 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.440 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.440 |