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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1k4qFADGlutathione reductase, mitochondrial1.8.1.7

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1k4qFADGlutathione reductase, mitochondrial1.8.1.71.000
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.748
1grhFADGlutathione reductase, mitochondrial1.8.1.70.642
1greFADGlutathione reductase, mitochondrial1.8.1.70.640
3grsFADGlutathione reductase, mitochondrial1.8.1.70.633
1grgFADGlutathione reductase, mitochondrial1.8.1.70.632
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.623
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.609
1graFADGlutathione reductase, mitochondrial1.8.1.70.602
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.591
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.589
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.576
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.571
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.544
1grbFADGlutathione reductase, mitochondrial1.8.1.70.540
2v6oFADThioredoxin glutathione reductase/0.537
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.499
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.497
2r9zFADGlutathione amide reductase/0.494
1gerFADGlutathione reductase1.8.1.70.483
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.483
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.481
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.469
3djgFADGlutathione reductase, mitochondrial1.8.1.70.467
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.461
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.455
2rabFADGlutathione amide reductase/0.455