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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1k22MELProthrombin3.4.21.5

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1k22MELProthrombin3.4.21.51.000
1nm6L86Prothrombin3.4.21.50.690
2zfr46UProthrombin3.4.21.50.653
1d3dBZTProthrombin3.4.21.50.651
1zgi382Prothrombin3.4.21.50.647
1d3pBT3Prothrombin3.4.21.50.645
1oytFSNProthrombin3.4.21.50.644
2anmCDOProthrombin3.4.21.50.641
1ypmRA4Prothrombin3.4.21.50.636
1sb1165Prothrombin3.4.21.50.631
3c1kT15Prothrombin3.4.21.50.625
1d9i00PProthrombin3.4.21.50.621
1ypjUIBProthrombin3.4.21.50.621
4bahMELProthrombin3.4.21.50.617
1c4uIH1Prothrombin3.4.21.50.616
2zhe13UProthrombin3.4.21.50.607
2zhw12UProthrombin3.4.21.50.605
4e7r0NWProthrombin3.4.21.50.603
2r2mI50Prothrombin3.4.21.50.600
1yplRA8Prothrombin3.4.21.50.599
4bakM67Prothrombin3.4.21.50.596
4baoMVFProthrombin3.4.21.50.594
2zhq27UProthrombin3.4.21.50.593
1z71L17Prothrombin3.4.21.50.592
2pksG44Prothrombin3.4.21.50.592
1k21IGNProthrombin3.4.21.50.588
1ta6177Prothrombin3.4.21.50.588
2v3oI26Prothrombin3.4.21.50.588
2zfq45UProthrombin3.4.21.50.588
4ax9N5NProthrombin3.4.21.50.588
2zda32UProthrombin3.4.21.50.583
1d6w00RProthrombin3.4.21.50.582
1ypeUIPProthrombin3.4.21.50.581
4ayy9MXProthrombin3.4.21.50.581
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.580
4az29MUProthrombin3.4.21.50.578
1c4yIH3Prothrombin3.4.21.50.577
1xm1GAHProthrombin3.4.21.50.577
2zfp19UProthrombin3.4.21.50.577
1jwtBLIProthrombin3.4.21.50.575
1mueCDDProthrombin3.4.21.50.575
2jh6894Prothrombin3.4.21.50.575
2zi224UProthrombin3.4.21.50.575
2jh5895Prothrombin3.4.21.50.574
3qwc98PProthrombin3.4.21.50.574
2cn0F25Prothrombin3.4.21.50.572
2cf8ESHProthrombin3.4.21.50.570
2zhf49UProthrombin3.4.21.50.570
4lxb7R9Prothrombin3.4.21.50.569
3p1799PProthrombin3.4.21.50.568
2v3hI25Prothrombin3.4.21.50.566
1mu6CDAProthrombin3.4.21.50.565
1w7gMIUProthrombin3.4.21.50.565
2zgb21UProthrombin3.4.21.50.565
1d4pBPPProthrombin3.4.21.50.564
2jh0701Prothrombin3.4.21.50.562
2bdyUNBProthrombin3.4.21.50.560
1riwOSCProthrombin3.4.21.50.559
1zrb062Prothrombin3.4.21.50.559
2bxtC2DProthrombin3.4.21.50.559
2cf9348Prothrombin3.4.21.50.559
3biu10UProthrombin3.4.21.50.558
4n3l2FNProthrombin3.4.21.50.558
1vzqSHYProthrombin3.4.21.50.556
2zgx29UProthrombin3.4.21.50.556
7kmeACE_0BN_CHG_PRRProthrombin3.4.21.50.556
2uuj896Prothrombin3.4.21.50.555
3eq02TSProthrombin3.4.21.50.554
2uuk897Prothrombin3.4.21.50.553
1ypgUIRProthrombin3.4.21.50.552
3qto10PProthrombin3.4.21.50.549
2zg050UProthrombin3.4.21.50.548
1t4u81AProthrombin3.4.21.50.547
4banM6SProthrombin3.4.21.50.547
1t4v14AProthrombin3.4.21.50.546
4bamMM9Prothrombin3.4.21.50.546
1zgv501Prothrombin3.4.21.50.545
2znk31UProthrombin3.4.21.50.544
2zff53UProthrombin3.4.21.50.541
1afeALZProthrombin3.4.21.50.540
1nzq162Prothrombin3.4.21.50.537
2zdv37UProthrombin3.4.21.50.536
1ypkCCRProthrombin3.4.21.50.534
2zc922UProthrombin3.4.21.50.533
4baqM4ZProthrombin3.4.21.50.532
3qtv06PProthrombin3.4.21.50.522
1a4wQWEProthrombin3.4.21.50.520
3dux64UProthrombin3.4.21.50.518
3utu1TSProthrombin3.4.21.50.518
1ae8AZLProthrombin3.4.21.50.514
4rn615UProthrombin3.4.21.50.513
5cmx0G6Prothrombin3.4.21.50.508
2zf051UProthrombin3.4.21.50.500
2bvs2CEProthrombin3.4.21.50.498
2gdeSN3Prothrombin3.4.21.50.487
4ayv9MQProthrombin3.4.21.50.486
3c27DKKProthrombin3.4.21.50.481
1c4vIH2Prothrombin3.4.21.50.470
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.464
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.463
1o0d163Prothrombin3.4.21.50.461
1ghv120Prothrombin3.4.21.50.456
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.455
2a2xNA9Prothrombin3.4.21.50.454
2cv2GSUGlutamate--tRNA ligase6.1.1.170.446
2ziq26UProthrombin3.4.21.50.446
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.444
3dhk23UProthrombin3.4.21.50.443
3fhxPXLPyridoxal kinase2.7.1.350.443
1ib0NADNADH-cytochrome b5 reductase 31.6.2.20.442
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.442
1mu8CDBProthrombin3.4.21.50.441
1ny2ARG_PRO_PRO_GLYProthrombin3.4.21.50.441
4loy6XSProthrombin3.4.21.50.440