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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1jujLYAThymidylate synthase2.1.1.45

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1jujLYAThymidylate synthase2.1.1.451.000
1ju6LYAThymidylate synthase2.1.1.450.647
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.562
1f28F89Thymidylate synthase2.1.1.450.552
1kzjCB3Thymidylate synthase/0.551
1hvyD16Thymidylate synthase2.1.1.450.550
1tduCB3Thymidylate synthase/0.544
1jutLYDThymidylate synthase/0.540
4eilCB3Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.540
1kceCB3Thymidylate synthase/0.538
1ci7CB3Thymidylate synthase2.1.1.450.530
2bbqPFGThymidylate synthase/0.528
1nceCB3Thymidylate synthase/0.526
1dnaCB3Thymidylate synthase/0.523
1an5CB3Thymidylate synthase/0.519
2aazCB3Thymidylate synthase2.1.1.450.517
3uwlFOZThymidylate synthase/0.514
2tscCB3Thymidylate synthase/0.512
4ez8DHFThymidylate synthase2.1.1.450.510
1jtuLYBThymidylate synthase/0.509
4fogC2FThymidylate synthase ThyA/0.508
3bgxMEFThymidylate synthase/0.506
2ftoCB3Thymidylate synthase/0.505
4foxD16Thymidylate synthase ThyA/0.505
1jtqLY3Thymidylate synthase/0.503
4o7uTHFThymidylate synthase/0.500
2tsrD16Thymidylate synthase2.1.1.450.494
3bhrTHGThymidylate synthase/0.492
1zprCB3Thymidylate synthase/0.488
2kceD16Thymidylate synthase/0.487
1f4fTP3Thymidylate synthase/0.486
1axwMTXThymidylate synthase/0.484
1bq1CB3Thymidylate synthase/0.484
1sejF89Bifunctional dihydrofolate reductase-thymidylate synthase/0.484
3k2hLYABifunctional dihydrofolate reductase-thymidylate synthase/0.482
4fqsLYAThymidylate synthase ThyA/0.481
1tsdF89Thymidylate synthase/0.477
4gevCB3Thymidylate synthase/0.477
1trgCB3Thymidylate synthase/0.474
3l0lHC3Nuclear receptor ROR-gamma/0.474
1f4gTP4Thymidylate synthase/0.473
3bhlTHGThymidylate synthase/0.472
1aiqCB3Thymidylate synthase/0.469
1tysDHFThymidylate synthase/0.468
1fwmCB3Thymidylate synthase/0.462
4eb4D16Thymidylate synthase2.1.1.450.462
4knzCB3Thymidylate synthase/0.461
1dduCB3Thymidylate synthase/0.459
1synF89Thymidylate synthase/0.456
1kziTHGThymidylate synthase/0.455
3kytHC2Nuclear receptor ROR-gamma/0.454
4jbtASDCytochrome P450 monooxygenase/0.447
2vf0F89Thymidylate synthase/0.446
1i00D16Thymidylate synthase2.1.1.450.444
1blzACVIsopenicillin N synthase1.21.3.10.441
1bk0ACVIsopenicillin N synthase1.21.3.10.440
3p99LNPLanosterol 14-alpha-demethylase/0.440
4irnFADAnaB/0.440