sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1jdb | ADP | Carbamoyl-phosphate synthase large chain |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1jdb | ADP | Carbamoyl-phosphate synthase large chain | / | 1.000 | |
| 1t36 | ADP | Carbamoyl-phosphate synthase large chain | / | 0.552 | |
| 3wo1 | ADP | Alanine--anticapsin ligase | / | 0.539 | |
| 1a9x | ADP | Carbamoyl-phosphate synthase large chain | / | 0.527 | |
| 3hrc | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.504 | |
| 1cm8 | ANP | Mitogen-activated protein kinase 12 | / | 0.503 | |
| 2pyw | ADP | Methylthioribose kinase | 2.7.1.100 | 0.502 | |
| 2w6n | OA2 | Biotin carboxylase | 6.3.4.14 | 0.495 | |
| 4zhq | ACP | Tubulin tyrosine ligase | / | 0.494 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.492 | |
| 1bxr | ANP | Carbamoyl-phosphate synthase large chain | / | 0.491 | |
| 2b4r | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.490 | |
| 3s87 | DGT | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.490 | |
| 2wtk | ANP | STE20-related kinase adapter protein alpha | / | 0.489 | |
| 4i2q | 1BT | Gag-Pol polyprotein | 2.7.7.49 | 0.489 | |
| 3cok | ANP | Serine/threonine-protein kinase PLK4 | 2.7.11.21 | 0.488 | |
| 3orz | BI4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.488 | |
| 3p23 | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.487 | |
| 3wo0 | ADP | Alanine--anticapsin ligase | / | 0.487 | |
| 1pk8 | ATP | Synapsin-1 | / | 0.486 | |
| 1q8w | M77 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.484 | |
| 1wvy | STU | Death-associated protein kinase 1 | 2.7.11.1 | 0.484 | |
| 4dqw | ATP | Inosine-5'-monophosphate dehydrogenase | / | 0.484 | |
| 3t99 | ADP | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 | / | 0.482 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.482 | |
| 4c5b | ADP | D-alanine--D-alanine ligase B | 6.3.2.4 | 0.481 | |
| 2r3f | SC8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.479 | |
| 2cvx | DGT | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.478 | |
| 3vpb | ADP | Glutamate--LysW ligase ArgX | 6.3.2 | 0.477 | |
| 2bxi | AZQ | Serum albumin | / | 0.476 | |
| 2cvu | ANP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.475 | |
| 2y9q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.475 | |
| 4ki8 | ADP | 60 kDa chaperonin | / | 0.475 | |
| 4o4i | ACP | Tubulin tyrosine ligase | / | 0.475 | |
| 4fhj | 0TZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.472 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 1ihx | SND | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.470 | |
| 1mqb | ANP | Ephrin type-A receptor 2 | 2.7.10.1 | 0.470 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.470 | |
| 4fa6 | 0TA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.470 | |
| 1h1p | CMG | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.469 | |
| 2gn9 | UPG | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.469 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.469 | |
| 1hck | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.468 | |
| 2vqd | AP2 | Biotin carboxylase | 6.3.4.14 | 0.468 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.468 | |
| 3rsr | N5P | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.468 | |
| 3tw6 | ADP | Pyruvate carboxylase | / | 0.468 | |
| 4dh5 | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.468 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.468 | |
| 5bpf | ADP | D-alanine--D-alanine ligase | / | 0.468 | |
| 1gjr | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.467 | |
| 1ir3 | ANP | Insulin receptor | 2.7.10.1 | 0.467 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.467 | |
| 3vvh | 4BM | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.467 | |
| 2xtz | GSP | Guanine nucleotide-binding protein alpha-1 subunit | / | 0.466 | |
| 3qsb | 743 | Beta sliding clamp | 2.7.7.7 | 0.466 | |
| 3spt | UD1 | Bifunctional protein GlmU | / | 0.466 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 4j6i | 1JV | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 1jkk | ANP | Death-associated protein kinase 1 | 2.7.11.1 | 0.465 | |
| 2cvv | ANP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.465 | |
| 2vto | LZ8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 4fkl | CK2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 4l2i | FAD | Electron transfer flavoprotein alpha/beta-subunit | / | 0.465 | |
| 4o1p | ANP | Ribonuclease L | / | 0.465 | |
| 5c1o | ANP | D-alanine--D-alanine ligase | / | 0.465 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.464 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 4c5c | ATP | D-alanine--D-alanine ligase B | 6.3.2.4 | 0.464 | |
| 4eh5 | 0OM | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 4hjf | C2E | GGDEF family protein | / | 0.464 | |
| 4iaf | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.464 | |
| 4wbb | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.464 | |
| 1uu8 | BI1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.463 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.463 | |
| 3k8t | DGT | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.463 | |
| 3lfq | A28 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.463 | |
| 1h1w | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.462 | |
| 1q3q | ANP | Thermosome subunit alpha | / | 0.462 | |
| 3ruv | ANP | Chaperonin | / | 0.462 | |
| 3uwq | U5P | Orotidine 5'-phosphate decarboxylase | / | 0.462 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.462 | |
| 4y12 | AGS | Serine/threonine-protein kinase PknG | 2.7.11.1 | 0.462 | |
| 2cdu | FAD | NADH oxidase | / | 0.461 | |
| 2cvw | TTP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.461 | |
| 2qdx | FAD | Ferredoxin--NADP+ reductase | / | 0.461 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.461 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 3o0g | 3O0 | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.461 | |
| 4jrn | ANP | Rhoptry kinase family protein | / | 0.461 | |
| 4pd6 | URI | Nucleoside permease | / | 0.461 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.461 | |
| 1b39 | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 1tdn | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.460 | |
| 2vxo | XMP | GMP synthase [glutamine-hydrolyzing] | 6.3.5.2 | 0.460 | |
| 2xs0 | ANP | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.460 | |
| 4lv7 | ADP | Inositol-pentakisphosphate 2-kinase | 2.7.1.158 | 0.460 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.459 | |
| 1ivh | COS | Isovaleryl-CoA dehydrogenase, mitochondrial | 1.3.8.4 | 0.459 | |
| 2j7p | GNP | Signal recognition particle protein | / | 0.459 | |
| 2j7p | GNP | Signal recognition particle receptor FtsY | / | 0.459 | |
| 2p0a | ANP | Synapsin-3 | / | 0.459 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.459 | |
| 2vwp | NDP | Glucose 1-dehydrogenase | / | 0.459 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.459 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 5aut | 2AN | Death-associated protein kinase 1 | 2.7.11.1 | 0.459 | |
| 1ykr | 628 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.458 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.458 | |
| 4xhg | ADP | Uncharacterized protein | / | 0.458 | |
| 4xx9 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.458 | |
| 4yhj | AN2 | G protein-coupled receptor kinase 4 | 2.7.11.16 | 0.458 | |
| 5kj1 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.458 | |
| 1lhw | ESM | Sex hormone-binding globulin | / | 0.457 | |
| 1tqp | ATP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.457 | |
| 1za1 | CTP | Aspartate carbamoyltransferase regulatory chain | / | 0.457 | |
| 2cvy | TTP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.457 | |
| 2hgs | ADP | Glutathione synthetase | 6.3.2.3 | 0.457 | |
| 2pc4 | ASP_TRP_ASN | Fructose-bisphosphate aldolase | 4.1.2.13 | 0.457 | |
| 3vpc | ADP | Glutamate--LysW ligase ArgX | 6.3.2 | 0.457 | |
| 3w0s | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.457 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.457 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.456 | |
| 2q6b | HR2 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.456 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.456 | |
| 3ml9 | ML9 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.456 | |
| 3wnz | ADP | Alanine--anticapsin ligase | / | 0.456 | |
| 4axf | ANP | Inositol-pentakisphosphate 2-kinase | 2.7.1.158 | 0.456 | |
| 4f7n | 0SV | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.456 | |
| 4n57 | ADP | APH(2'')-Id | / | 0.456 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.456 | |
| 2etm | 7PY | Focal adhesion kinase 1 | 2.7.10.2 | 0.455 | |
| 3g8d | ADP | Biotin carboxylase | 6.3.4.14 | 0.455 | |
| 3vet | ADP | nebramycin 5' synthase | 6.1.2.2 | 0.455 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.455 | |
| 3w0n | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.455 | |
| 5c1p | ADP | D-alanine--D-alanine ligase | / | 0.455 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 1ict | T44 | Transthyretin | / | 0.454 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.454 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 2c68 | CT6 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 2exm | ZIP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 2xbj | XBJ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.454 | |
| 4bl1 | ANP | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.454 | |
| 4crs | AGS | Serine/threonine-protein kinase N2 | 2.7.11.13 | 0.454 | |
| 4ktc | 1X3 | Genome polyprotein | 3.4.21.98 | 0.454 | |
| 4l2y | XXK | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | / | 0.454 | |
| 4lrj | ANP | Uncharacterized protein | / | 0.454 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.454 | |
| 1jkl | ANP | Death-associated protein kinase 1 | 2.7.11.1 | 0.453 | |
| 1mk1 | APR | MutT/nudix family protein | / | 0.453 | |
| 2bkk | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.453 | |
| 2o7o | DXT | Tetracycline repressor protein class D | / | 0.453 | |
| 2pe1 | 517 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.453 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3eq1 | DPM | Porphobilinogen deaminase | 2.5.1.61 | 0.453 | |
| 3hmm | 855 | TGF-beta receptor type-1 | 2.7.11.30 | 0.453 | |
| 3u10 | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | / | 0.453 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 4ful | 0VU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4nt0 | 3DU | Orotidine 5'-phosphate decarboxylase | 4.1.1.23 | 0.453 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.453 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.453 | |
| 1q97 | ATP | Serine/threonine-protein kinase SKY1 | 2.7.11.1 | 0.452 | |
| 2ijm | ATP | Focal adhesion kinase 1 | 2.7.10.2 | 0.452 | |
| 2xan | ANP | Inositol-pentakisphosphate 2-kinase | 2.7.1.158 | 0.452 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 3jrx | S1A | Acetyl-CoA carboxylase 2 | / | 0.452 | |
| 3k3j | F4C | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3n8n | N88 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.452 | |
| 3pnl | ADP | PEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL | 2.7 | 0.452 | |
| 3qft | NAP | NADPH--cytochrome P450 reductase | / | 0.452 | |
| 3rpv | 26Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 3s8a | DGT | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.452 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 4ii5 | ADP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 4ot2 | NPS | Serum albumin | / | 0.452 | |
| 1b38 | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 1d7y | FAD | Ferredoxin reductase | / | 0.451 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1xjn | DTP | Vitamin B12-dependent ribonucleotide reductase | / | 0.451 | |
| 2b9w | FAD | Putative aminooxidase | / | 0.451 | |
| 3kkv | B99 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
| 3mzh | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.451 | |
| 3qu0 | X40 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 3qyw | 6PB | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.451 | |
| 3sjz | GNP | Translation initiation factor 2 subunit gamma | / | 0.451 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.451 | |
| 4l3j | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.451 | |
| 4m69 | ANP | Receptor-interacting serine/threonine-protein kinase 3 | 2.7.11.1 | 0.451 | |
| 5ap7 | SVE | Dual specificity protein kinase TTK | 2.7.12.1 | 0.451 | |
| 1dv2 | ATP | Biotin carboxylase | 6.3.4.14 | 0.450 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.450 | |
| 2eud | ANP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.450 | |
| 3gg0 | FMN | Uncharacterized protein | / | 0.450 | |
| 3gnq | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.450 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3nsz | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.450 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3tku | M77 | Serine/threonine-protein kinase MRCK beta | 2.7.11.1 | 0.450 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.450 | |
| 4jky | ADP | Adenylate kinase | / | 0.450 | |
| 5c7o | NAD | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific | 1.2.1.12 | 0.450 | |
| 1npt | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.449 | |
| 1peq | TTP | Ribonucleoside-diphosphate reductase 2 subunit alpha | 1.17.4.1 | 0.449 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.449 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 3cd5 | 7HI | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.449 | |
| 3et7 | 349 | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.449 | |
| 3otu | BI4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 4da4 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.449 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.449 | |
| 1oi9 | N20 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 2b9f | ADP | Mitogen-activated protein kinase FUS3 | 2.7.11.24 | 0.448 | |
| 2i0y | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.448 | |
| 3cbs | R12 | Cellular retinoic acid-binding protein 2 | / | 0.448 | |
| 3gfy | FMN | Uncharacterized protein | / | 0.448 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.448 | |
| 3s8c | ANP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.448 | |
| 3tb9 | ANP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.448 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.448 | |
| 3x2v | ATP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 4l45 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.448 | |
| 4zbr | NPS | Serum albumin | / | 0.448 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.447 | |
| 1me8 | RVP | Inosine-5'-monophosphate dehydrogenase | / | 0.447 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.447 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.447 | |
| 1uu3 | LY4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.447 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 1w82 | L10 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.447 | |
| 2pan | FAD | Glyoxylate carboligase | 4.1.1.47 | 0.447 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 2z08 | ATP | Universal stress protein family | / | 0.447 | |
| 3ac1 | KZI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.447 | |
| 3le6 | 2BZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3qxp | X64 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3ral | 04Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3zxs | FAD | Deoxyribodipyrimidine photolyase-related protein | / | 0.447 | |
| 4iay | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.447 | |
| 4wou | GDP | Phosphoenolpyruvate carboxykinase [GTP] | / | 0.447 | |
| 4zs2 | FLU | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.447 | |
| 5fs7 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.447 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.447 | |
| 1bcp | ATP | Pertussis toxin subunit 4 | / | 0.446 | |
| 1bcp | ATP | Pertussis toxin subunit 5 | / | 0.446 | |
| 1tqm | ANP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.446 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 2oo7 | AP5 | Adenylate kinase | / | 0.446 | |
| 2qkr | IXM | Cdc2-like CDK2/CDC28 like protein kinase | / | 0.446 | |
| 2v51 | ATP | Actin, alpha skeletal muscle | / | 0.446 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2wou | ZZF | TGF-beta receptor type-1 | 2.7.11.30 | 0.446 | |
| 3fwr | ADP | Transcriptional repressor CcpN | / | 0.446 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.446 | |
| 3lfs | A07 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3lmg | ANP | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.446 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 3pls | ANP | Macrophage-stimulating protein receptor | 2.7.10.1 | 0.446 | |
| 3r8u | Z31 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3vgl | ANP | Glucokinase | / | 0.446 | |
| 3wow | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 4h3q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.446 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.446 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.446 | |
| 5la6 | ACP | Tubulin tyrosine ligase | / | 0.446 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.445 | |
| 1h1q | 2A6 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1mjh | ATP | Universal stress protein MJ0577 | / | 0.445 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.445 | |
| 2bx8 | AZQ | Serum albumin | / | 0.445 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 2dpx | GDP | GTP-binding protein RAD | / | 0.445 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.445 | |
| 3ujl | A8S | Abscisic acid receptor PYL2 | / | 0.445 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.445 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4fx3 | 60K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 4fyx | DCP | Aspartate carbamoyltransferase regulatory chain | / | 0.445 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.445 | |
| 4s32 | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.445 | |
| 5cu6 | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 5dby | NPS | Serum albumin | / | 0.445 | |
| 5htp | ANP | Probable sugar kinase | / | 0.445 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.444 | |
| 1ogu | ST8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 1oiu | N76 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 1orr | CDP | CDP-paratose 2-epimerase | / | 0.444 | |
| 1um0 | FMN | Chorismate synthase | / | 0.444 | |
| 2bxa | C1F | Serum albumin | / | 0.444 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.444 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.444 | |
| 2vtp | LZ9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.444 | |
| 2ydk | YDK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2ylx | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.444 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3gfe | P37 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.444 | |
| 3nun | JMZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 3w0q | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.444 | |
| 4bcq | TJF | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 4bi1 | ZO6 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.444 | |
| 4eol | 1RO | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 4g3q | UD1 | Bifunctional protein GlmU | / | 0.444 | |
| 4gih | 0X5 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.444 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.444 | |
| 4ylh | YE1 | (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase | / | 0.444 | |
| 5dac | AGS | Uncharacterized protein | / | 0.444 | |
| 1aq1 | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 1nmd | ATP | Major actin | / | 0.443 | |
| 1uu7 | BI2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 1uvr | BI8 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2c9c | ATP | Psp operon transcriptional activator | / | 0.443 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.443 | |
| 2vgo | AD5 | Aurora kinase B-A | 2.7.11.1 | 0.443 | |
| 3a8w | ATP | Protein kinase C iota type | 2.7.11.13 | 0.443 | |
| 3cgf | JNF | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.443 | |
| 3gg1 | FMN | Uncharacterized protein | / | 0.443 | |
| 3hpq | AP5 | Adenylate kinase | / | 0.443 | |
| 3kdi | A8S | Abscisic acid receptor PYL2 | / | 0.443 | |
| 3qwj | X6A | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3r0t | FU9 | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 4g3s | UD1 | Bifunctional protein GlmU | / | 0.443 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.443 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.443 | |
| 1g28 | FMN | PHY3 | / | 0.442 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1zar | ADP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.442 | |
| 2bts | U32 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2gn8 | NAP | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.442 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.442 | |
| 2iid | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.442 | |
| 2iw6 | QQ2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2j0l | ANP | Focal adhesion kinase 1 | 2.7.10.2 | 0.442 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.442 | |
| 2x5z | GDD | Mannose-1-phosphate guanylyltransferase | / | 0.442 | |
| 3ddp | RC8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3fzr | 3JZ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.442 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.442 | |
| 3qql | X03 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3r9o | Z71 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3rah | O1Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3vew | ADP | nebramycin 5' synthase | 6.1.2.2 | 0.442 | |
| 4aw0 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 4f6s | 0SQ | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.442 | |
| 4hyu | 1BK | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.442 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.442 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.442 | |
| 4uof | DAT | Nucleoside diphosphate kinase | / | 0.442 | |
| 4xt4 | NAP | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.442 | |
| 5c8y | ACP | Tubulin tyrosine ligase | / | 0.442 | |
| 5cno | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 5eg3 | ACP | Fibroblast growth factor receptor 2 | / | 0.442 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1csn | ATP | Casein kinase I homolog 1 | 2.7.11.1 | 0.441 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.441 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 1w2x | RCP | Acetyl-CoA carboxylase | / | 0.441 | |
| 1xal | NAD | 3-dehydroquinate synthase | / | 0.441 | |
| 1zao | ATP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.441 | |
| 2ek9 | BES | Aminopeptidase | / | 0.441 | |
| 2xpv | MIY | Tetracycline repressor protein class D | / | 0.441 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.441 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 3qf9 | NM8 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 3qrt | X14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3r9n | Z68 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3vs2 | VSB | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.441 | |
| 3w8r | ACP | Uridine kinase | / | 0.441 | |
| 4cry | ACO | PanD regulatory factor | / | 0.441 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 4g2i | 0VQ | Vitamin D3 receptor | / | 0.441 | |
| 4hh0 | FMN | AppA protein | / | 0.441 | |
| 4j71 | 1JX | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.441 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.441 | |
| 4lj8 | ADP | Chaperone protein ClpB | / | 0.441 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.441 | |
| 4zgn | ATP | Cell division cycle protein 123 | / | 0.441 | |
| 5av2 | KMP | Death-associated protein kinase 1 | 2.7.11.1 | 0.441 | |
| 1coz | CTP | Glycerol-3-phosphate cytidylyltransferase | 2.7.7.39 | 0.440 | |
| 1ie4 | T44 | Transthyretin | / | 0.440 | |
| 1jm6 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.440 | |
| 1osv | CHC | Bile acid receptor | / | 0.440 | |
| 1ouy | 094 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.440 | |
| 2jko | BIJ | Focal adhesion kinase 1 | 2.7.10.2 | 0.440 | |
| 2q28 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.440 | |
| 2v3a | FAD | Rubredoxin-NAD(+) reductase | 1.18.1.1 | 0.440 | |
| 2w05 | FRT | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3d2r | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.440 | |
| 3ddq | RRC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3dj4 | UD1 | Bifunctional protein GlmU | / | 0.440 | |
| 3pj8 | 404 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3qfr | NAP | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 3qtz | X42 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3ub5 | ATP | Actin, cytoplasmic 1 | / | 0.440 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4eqc | XR1 | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.440 | |
| 4fkw | 62K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4fl3 | ANP | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.440 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.440 | |
| 4h1m | 0YJ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.440 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.440 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.440 | |
| 4lsm | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.440 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.440 | |
| 5eom | CTP | Putative nucleotidyltransferase MAB21L1 | / | 0.440 | |
| 5ify | UMP | Glucose-1-phosphate thymidylyltransferase | / | 0.440 | |
| 5ikr | ID8 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.440 |