sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 1.000 | |
| 3qly | 55V | Uncharacterized protein | / | 0.641 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.626 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.613 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.603 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.602 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.597 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.596 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.596 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.592 | |
| 3cse | N22 | Uncharacterized protein | / | 0.589 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.581 | |
| 3eej | 53R | Uncharacterized protein | / | 0.578 | |
| 3eek | 53S | Uncharacterized protein | / | 0.577 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.577 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.573 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.565 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.563 | |
| 3eem | 53V | Uncharacterized protein | / | 0.562 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.562 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.561 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.559 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.559 | |
| 3eel | 53T | Uncharacterized protein | / | 0.554 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.553 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.553 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.553 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.552 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.547 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.545 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.535 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.535 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.531 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.530 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.526 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.521 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.513 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.511 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.509 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.508 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.508 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.502 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.494 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.494 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.488 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.487 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.487 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.486 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.486 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.483 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.482 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.481 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.481 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.477 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.477 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.476 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.475 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.472 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.470 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.468 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.467 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.465 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.459 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.458 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2tsc | CB3 | Thymidylate synthase | / | 0.457 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.457 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.457 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.454 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.454 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.446 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.446 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.446 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.444 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.444 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2pnu | ENM | Androgen receptor | / | 0.443 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.443 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.443 | |
| 2bxq | IMN | Serum albumin | / | 0.442 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.442 | |
| 3jw3 | TOP | Dihydrofolate reductase | / | 0.442 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.441 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.441 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.440 | |
| 4l8u | 9AZ | Serum albumin | / | 0.440 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 |