scPDB - Distribution of Binding site Similarity values of 1j3j entry / Site 1

PDB ID	HET	Uniprot Name	EC Number
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	1.000
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.664
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.651
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.650
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.643
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.624
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.612
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.610
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.603
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.601
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.599
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.591
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.590
2blb	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.590
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.589
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.589
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.588
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.587
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.587
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.582
3qly	55V	Uncharacterized protein	/	0.582
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.581
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.578
3qlz	QLZ	Uncharacterized protein	/	0.578
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.578
3um8	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.577
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.576
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.572
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.571
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.570
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.565
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.565
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.564
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.563
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.563
3qlx	QLR	Uncharacterized protein	/	0.562
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.560
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.559
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.556
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.556
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.554
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.553
2w3v	TOP	Dihydrofolate reductase	/	0.551
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.550
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.550
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.550
2zza	FOL	Dihydrofolate reductase	/	0.547
3cse	N22	Uncharacterized protein	/	0.547
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.545
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.544
3dg8	RJ6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.544
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.543
5ccc	DDF	Dihydrofolate reductase	1.5.1.3	0.543
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.542
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.542
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.541
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.541
2w3w	VG9	Dihydrofolate reductase	/	0.539
4h98	14Q	Uncharacterized protein	/	0.539
3eem	53V	Uncharacterized protein	/	0.537
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.536
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.535
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.533
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.533
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.532
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.532
3sa1	6DR	Dihydrofolate reductase	/	0.532
3nxo	D2B	Dihydrofolate reductase	1.5.1.3	0.531
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.530
1ia1	TQ3	Dihydrofolate reductase	1.5.1.3	0.529
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.528
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.527
1ia4	TQ6	Dihydrofolate reductase	1.5.1.3	0.526
1s3w	TQT	Dihydrofolate reductase	1.5.1.3	0.526
3rg9	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.526
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.525
3jwc	EKB	Dihydrofolate reductase	/	0.525
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.525
3ql3	FOL	Dihydrofolate reductase	1.5.1.3	0.524
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.524
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.523
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.523
1dre	MTX	Dihydrofolate reductase	1.5.1.3	0.522
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.522
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.522
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.520
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.520
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.520
3tq9	MTX	Dihydrofolate reductase	/	0.519
1rx5	DDF	Dihydrofolate reductase	1.5.1.3	0.518
3eej	53R	Uncharacterized protein	/	0.518
4elb	34R	Dihydrofolate reductase	/	0.518
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.518
3eek	53S	Uncharacterized protein	/	0.517
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.517
4fhb	FOL	Dihydrofolate reductase	1.5.1.3	0.516
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.516
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.515
3ia4	MTX	Dihydrofolate reductase	/	0.515
4nx7	FOL	Dihydrofolate reductase	1.5.1.3	0.514
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.513
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.512
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.512
3tqb	FOL	Dihydrofolate reductase	/	0.511
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.510
4i1n	FOL	Dihydrofolate reductase	1.5.1.3	0.508
3i8a	N22	Dihydrofolate reductase	1.5.1.3	0.507
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.506
3sgv	2BJ	Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	2.5.1.31	0.506
1ia3	TQ5	Dihydrofolate reductase	1.5.1.3	0.505
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.505
3r33	6ME	Dihydrofolate reductase	1.5.1.3	0.505
3jwm	5WB	Dihydrofolate reductase	/	0.504
4nx6	FOL	Dihydrofolate reductase	1.5.1.3	0.504
1mkd	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.503
3srq	Q19	Dihydrofolate reductase	1.5.1.3	0.503
4p66	MTX	Dihydrofolate reductase	/	0.503
3eel	53T	Uncharacterized protein	/	0.502
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.502
3nxy	D2H	Dihydrofolate reductase	1.5.1.3	0.501
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.500
4j6c	STR	Cytochrome P450 monooxygenase	/	0.500
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.500
1szm	BI4	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.499
2cig	1DG	Dihydrofolate reductase	1.5.1.3	0.498
3sa2	7DR	Dihydrofolate reductase	/	0.498
3sh2	5DR	Dihydrofolate reductase	1.5.1.3	0.498
3srs	M23	Dihydrofolate reductase	1.5.1.3	0.498
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.498
4i13	FOL	Dihydrofolate reductase	1.5.1.3	0.498
3sai	9DR	Dihydrofolate reductase	/	0.497
3tq8	TOP	Dihydrofolate reductase	/	0.497
4ele	31I	Dihydrofolate reductase	/	0.497
1rx7	FOL	Dihydrofolate reductase	1.5.1.3	0.496
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.496
3ml8	ML8	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.495
4fjy	FJY	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.494
1dyr	TOP	Dihydrofolate reductase	1.5.1.3	0.493
2chx	090	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.493
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.492
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.492
1sd2	MTH	S-methyl-5'-thioadenosine phosphorylase	/	0.491
1vkg	CRI	Histone deacetylase 8	3.5.1.98	0.491
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.491
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.491
3oji	PYV	Abscisic acid receptor PYL3	/	0.491
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.490
1fmj	RTL	Retinol dehydratase	/	0.490
4ddr	MMV	Dihydrofolate reductase	1.5.1.3	0.490
1bzf	TMQ	Dihydrofolate reductase	1.5.1.3	0.489
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.489
4dqu	NAI	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.489
7dfr	FOL	Dihydrofolate reductase	1.5.1.3	0.489
1rf7	DHF	Dihydrofolate reductase	1.5.1.3	0.488
3jw5	TOP	Dihydrofolate reductase	/	0.488
1ia2	TQ4	Dihydrofolate reductase	1.5.1.3	0.487
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.487
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.487
5d7q	4I5	NAD-dependent protein deacetylase sirtuin-2	3.5.1	0.487
2idz	ZID	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.486
4qjc	IXE	Dihydrofolate reductase	1.5.1.3	0.486
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.485
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.485
3sqy	Q11	Dihydrofolate reductase	1.5.1.3	0.485
4gyz	D5M	Tyrosyl-DNA phosphodiesterase 2	3.1.4	0.485
4x5j	FOL	Dihydrofolate reductase	1.5.1.3	0.485
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.483
3p3z	P3Z	Putative cytochrome P450	/	0.483
4gdy	0X1	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	2.6.1.39	0.483
4kne	1CY	Dihydrofolate reductase	1.5.1.3	0.483
2in6	839	Wee1-like protein kinase	2.7.10.2	0.482
2jed	LG8	Protein kinase C theta type	2.7.11.13	0.482
3dga	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.482
2y6f	M9F	Isopenicillin N synthase	1.21.3.1	0.481
3nj0	PYV	Abscisic acid receptor PYL2	/	0.481
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.480
2ejz	SAH	Diphthine synthase	/	0.480
3lnb	COA	N-acetyltransferase family protein	/	0.480
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.479
2z2w	770	Wee1-like protein kinase	2.7.10.2	0.479
3el8	PD5	Proto-oncogene tyrosine-protein kinase Src	2.7.10.2	0.479
4cdm	FO1	Deoxyribodipyrimidine photolyase	/	0.479
3dau	MTX	Dihydrofolate reductase	1.5.1.3	0.478
3sgy	06W	Dihydrofolate reductase	1.5.1.3	0.478
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.478
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.477
2wo7	ASV	Isopenicillin N synthase	1.21.3.1	0.477
3ns2	PYV	Abscisic acid receptor PYL2	/	0.477
4j6b	PLO	Cytochrome P450 monooxygenase	/	0.477
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.476
3ezp	B3N	Histone deacetylase 8	3.5.1.98	0.476
4p68	MTX	Dihydrofolate reductase	/	0.476
4x5i	FOL	Dihydrofolate reductase	1.5.1.3	0.476
5dc5	B3N	Histone deacetylase 8	3.5.1.98	0.476
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.475
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.475
2azz	TCH	Phospholipase A2, major isoenzyme	3.1.1.4	0.475
2zce	PYL	Pyrrolysine--tRNA ligase	/	0.475
3gc9	B45	Mitogen-activated protein kinase 11	2.7.11.24	0.475
4hnc	0UT	Mandelate racemase	/	0.475
1kl2	FON	Serine hydroxymethyltransferase	/	0.474
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.474
1rc4	DDF	Dihydrofolate reductase	1.5.1.3	0.474
3kb0	A8S	Abscisic acid receptor PYL2	/	0.474
4ej1	FOL	Dihydrofolate reductase	1.5.1.3	0.474
1ao8	MTX	Dihydrofolate reductase	1.5.1.3	0.473
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.473
1m79	MQ1	Dihydrofolate reductase	1.5.1.3	0.473
1qzf	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.473
1rx8	FOL	Dihydrofolate reductase	1.5.1.3	0.473
2chw	039	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.473
3gcq	1BU	Mitogen-activated protein kinase 14	/	0.473
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.473
4fhk	0U0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.473
4lwa	Q13	Nitric oxide synthase oxygenase	1.14.13.165	0.473
4rbs	0RV	Metallo-beta-lactamase type 2	/	0.473
1dyh	DZF	Dihydrofolate reductase	1.5.1.3	0.472
1dyi	FOL	Dihydrofolate reductase	1.5.1.3	0.472
1ewy	FAD	Ferredoxin--NADP reductase	1.18.1.2	0.472
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.472
4qe6	JN3	Bile acid receptor	/	0.472
1kzj	CB3	Thymidylate synthase	/	0.471
2pr2	DG1	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.471
2wqp	WQP	Polysialic acid capsule biosynthesis protein SiaC	/	0.471
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.471
3itz	P66	Mitogen-activated protein kinase 14	/	0.471
3tda	PN0	Cytochrome P450 2D6	/	0.471
4at2	ASD	Possible succinate dehydrogenase	/	0.471
4dvq	1CA	Cytochrome P450 11B2, mitochondrial	1.14.15.4	0.471
4jbt	ASD	Cytochrome P450 monooxygenase	/	0.471
4x5h	FOL	Dihydrofolate reductase	1.5.1.3	0.471
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.470
1ra2	FOL	Dihydrofolate reductase	1.5.1.3	0.470
1rh3	MTX	Dihydrofolate reductase	1.5.1.3	0.470
1zkl	IBM	High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	3.1.4.53	0.470
2cda	NAP	Glucose 1-dehydrogenase	/	0.470
3qm4	PN0	Cytochrome P450 2D6	/	0.470
4anx	534	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.470
4rlh	0WE	Enoyl-[acyl-carrier-protein] reductase [NADH]	/	0.470
4xoq	F42	Coenzyme F420:L-glutamate ligase	/	0.470
1bk0	ACV	Isopenicillin N synthase	1.21.3.1	0.469
1s7g	NAD	NAD-dependent protein deacylase 2	/	0.469
1xdd	AAY	Integrin alpha-L	/	0.469
2uag	UMA	UDP-N-acetylmuramoylalanine--D-glutamate ligase	6.3.2.9	0.469
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.469
4kp6	1S1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.469
1fml	RTL	Retinol dehydratase	/	0.468
1n71	COA	Aac(6')-Ii protein	/	0.468
2ojg	19A	Mitogen-activated protein kinase 1	2.7.11.24	0.468
3ix9	MTX	Dihydrofolate reductase	1.5.1.3	0.468
4e0u	0MV	Cyclic dipeptide N-prenyltransferase	/	0.468
1e90	MYC	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.467
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.467
3c1x	CKK	Hepatocyte growth factor receptor	2.7.10.1	0.467
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.467
4e5y	NDP	GDP-L-fucose synthase	1.1.1.271	0.467
5cc9	DDF	Dihydrofolate reductase	1.5.1.3	0.467
2o8h	227	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.466
2wi7	2KL	Heat shock protein HSP 90-alpha	/	0.466
2zba	ZBA	Trichothecene 3-O-acetyltransferase	/	0.466
3nxx	NDP	Dihydrofolate reductase	1.5.1.3	0.466
3t3q	9PL	Cytochrome P450 2A6	1.14.13	0.466
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.466
4egn	TWO	Cytochrome P450	/	0.466
4enh	FVX	Cholesterol 24-hydroxylase	/	0.466
4j8t	DOG	Uncharacterized PhzA/B-like protein PA3332	/	0.466
1oc1	ASV	Isopenicillin N synthase	1.21.3.1	0.465
1rd7	FOL	Dihydrofolate reductase	1.5.1.3	0.465
3fl8	RAR	Dihydrofolate reductase	/	0.465
3jyp	NAD	Quinate/shikimate dehydrogenase (NAD(+))	/	0.465
3pre	3RE	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.465
3vt7	VDX	Vitamin D3 receptor	/	0.465
3zku	HCV	Isopenicillin N synthase	1.21.3.1	0.465
4bgi	I4I	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.465
4i6h	1C8	Serine/threonine-protein kinase PLK2	2.7.11.21	0.465
4lt6	3AT	Poly(A) polymerase gamma	2.7.7.19	0.465
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.465
5hi6	MTX	Dihydrofolate reductase	/	0.465
5hs1	VOR	Lanosterol 14-alpha demethylase	/	0.465
1bsv	NDP	GDP-L-fucose synthase	/	0.464
1mc5	AHE	Alcohol dehydrogenase class-3	1.1.1.1	0.464
1rb2	FOL	Dihydrofolate reductase	1.5.1.3	0.464
1u71	MXA	Dihydrofolate reductase	1.5.1.3	0.464
2cy0	NAP	Shikimate dehydrogenase (NADP(+))	/	0.464
2p15	EZT	Estrogen receptor	/	0.464
2ph5	NAD	Homospermidine synthase	/	0.464
4g09	0VD	Histidinol dehydrogenase	/	0.464
4i8v	BHF	Cytochrome P450 1A1	1.14.14.1	0.464
4qa1	B3N	Histone deacetylase 8	3.5.1.98	0.464
1bws	NDP	GDP-L-fucose synthase	/	0.463
1db4	8IN	Phospholipase A2, membrane associated	/	0.463
1dr4	HBI	Dihydrofolate reductase	1.5.1.3	0.463
2j3j	HC4	NADPH-dependent oxidoreductase 2-alkenal reductase	1.3.1.74	0.463
2jb4	A14	Isopenicillin N synthase	1.21.3.1	0.463
2vn1	FK5	Peptidylprolyl isomerase	/	0.463
2y46	MIV	Mycinamicin IV hydroxylase/epoxidase	/	0.463
3fko	FKO	Mitogen-activated protein kinase 14	/	0.463
3fyw	XCF	Dihydrofolate reductase	1.5.1.3	0.463
3mdv	CL6	Cholesterol 24-hydroxylase	/	0.463
3ozd	4CT	S-methyl-5'-thioadenosine phosphorylase	/	0.463
4bge	PYW	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.463
4fhj	0TZ	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.463
1dgh	NDP	Catalase	1.11.1.6	0.462
1nce	CB3	Thymidylate synthase	/	0.462
1o5r	FR9	Adenosine deaminase	3.5.4.4	0.462
1ot7	IU5	Bile acid receptor	/	0.462
1xom	CIO	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.462
2b1z	17M	Estrogen receptor	/	0.462
2fm5	M99	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.462
3frf	XCF	Dihydrofolate reductase	1.5.1.3	0.462
3njo	PYV	Abscisic acid receptor PYR1	/	0.462
3ssn	MVI	Mycinamicin VI 2''-O-methyltransferase	/	0.462
4bfu	ZVU	Pantothenate kinase	2.7.1.33	0.462
4elb	34S	Dihydrofolate reductase	/	0.462
4j7x	SAS	Sepiapterin reductase	1.1.1.153	0.462
4lga	A2O	Abscisic acid receptor PYL2	/	0.462
4xwt	U5P	Ribonuclease J	/	0.462
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.461
2ovv	PFH	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.461
2q7g	CCL	Pyrrolysine--tRNA ligase	/	0.461
2qbl	CAM	Camphor 5-monooxygenase	1.14.15.1	0.461
2w9h	TOP	Dihydrofolate reductase	1.5.1.3	0.461
3h18	PMS	Esterase/lipase	/	0.461
3o56	ZG1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.461
3uic	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH]	/	0.461
3zsh	469	Mitogen-activated protein kinase 14	/	0.461
4j6d	TES	Cytochrome P450 monooxygenase	/	0.461
4phl	PIL	Phosphodiesterase	/	0.461
4uyf	73B	Bromodomain-containing protein 2	/	0.461
5fd8	A5A	Putative carboxypeptidase yocD	/	0.461
1rx6	DDF	Dihydrofolate reductase	1.5.1.3	0.460
1xp9	AIJ	Estrogen receptor	/	0.460
2c94	TSF	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.460
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.460
2x7h	PFN	Prostaglandin reductase 3	1	0.460
3exo	5MS	Beta-secretase 1	3.4.23.46	0.460
3g4i	D71	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.460
3h3s	H15	Collagen type IV alpha-3-binding protein	/	0.460
3zw3	ZW3	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.460
4qa0	SHH	Histone deacetylase 8	3.5.1.98	0.460
4r20	AER	Cytochrome P450 family 17 polypeptide 2	/	0.460
1bvr	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.459
1e7q	NAP	GDP-L-fucose synthase	/	0.459
1kqu	BR4	Phospholipase A2, membrane associated	/	0.459
1osv	CHC	Bile acid receptor	/	0.459
1ot7	CHC	Bile acid receptor	/	0.459
1ra3	MTX	Dihydrofolate reductase	1.5.1.3	0.459
1u2g	APR	NAD(P) transhydrogenase subunit alpha part 1	1.6.1.2	0.459
2cmo	M1L	Glutamate receptor 2	/	0.459
2fpc	SCG	Strictosidine synthase	4.3.3.2	0.459
2nn7	M29	Carbonic anhydrase 1	4.2.1.1	0.459
3c3d	FO1	2-phospho-L-lactate transferase	/	0.459
3lfc	Z86	Mitogen-activated protein kinase 14	/	0.459
3o0i	P54	Heat shock protein HSP 90-alpha	/	0.459
3srw	Q27	Dihydrofolate reductase	1.5.1.3	0.459
4elg	52J	Dihydrofolate reductase	/	0.459
4kz0	1UJ	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.459
1al8	DHP	Peroxisomal (S)-2-hydroxy-acid oxidase	1.1.3.15	0.458
1fxs	NAP	GDP-L-fucose synthase	/	0.458
1th6	OIN	Basic phospholipase A2 VRV-PL-VIIIa	3.1.1.4	0.458
2gv8	NDP	Thiol-specific monooxygenase	1.14.13	0.458
3btj	DEQ	HTH-type transcriptional regulator QacR	/	0.458
3h3t	16H	Collagen type IV alpha-3-binding protein	/	0.458
3nef	PYV	Abscisic acid receptor PYL1	/	0.458
3nr4	PYV	Abscisic acid receptor PYL2	/	0.458
3p67	FMN	Pentaerythritol tetranitrate reductase	/	0.458
4lc7	1WP	Beta-secretase 1	3.4.23.46	0.458
1m9k	7NI	Nitric oxide synthase, endothelial	1.14.13.39	0.457
1q20	PLO	Sulfotransferase family cytosolic 2B member 1	2.8.2.2	0.457
1rg7	MTX	Dihydrofolate reductase	1.5.1.3	0.457
2feu	CAM	Camphor 5-monooxygenase	1.14.15.1	0.457
2y98	MIV	Mycinamicin IV hydroxylase/epoxidase	/	0.457
3c3x	NAP	Eugenol synthase 1	1.1.1.318	0.457
3ddw	055	Glycogen phosphorylase, liver form	2.4.1.1	0.457
3gwf	FAD	Cyclohexanone monooxygenase	/	0.457
3h3r	14H	Collagen type IV alpha-3-binding protein	/	0.457
3iak	EV1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.457
4ap1	NAP	Steroid monooxygenase	/	0.457
4ddl	0JQ	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.457
4e37	NDP	Catalase	1.11.1.6	0.457
4fgc	PQ0	NADPH-dependent 7-cyano-7-deazaguanine reductase	1.7.1.13	0.457
4qa2	SHH	Histone deacetylase 8	3.5.1.98	0.457
1ra8	FOL	Dihydrofolate reductase	1.5.1.3	0.456
1vzd	CB3	Thymidylate synthase	/	0.456
1zky	689	Estrogen receptor	/	0.456
2jn3	JN3	Fatty acid-binding protein, liver	/	0.456
3a8w	ATP	Protein kinase C iota type	2.7.11.13	0.456
3e5a	VX6	Aurora kinase A	2.7.11.1	0.456
3pll	F06	Endothiapepsin	3.4.23.22	0.456
3uud	EST	Estrogen receptor	/	0.456
4at3	LTI	BDNF/NT-3 growth factors receptor	2.7.10.1	0.456
4euf	NAD	Trans-2-enoyl-CoA reductase [NADH]	/	0.456
4wdb	2AM	2',3'-cyclic-nucleotide 3'-phosphodiesterase	3.1.4.37	0.456
4y9u	NAP	NADPH--cytochrome P450 reductase	/	0.456
1hb3	SCV	Isopenicillin N synthase	1.21.3.1	0.455
1p44	GEQ	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.455
1qiq	ACC	Isopenicillin N synthase	1.21.3.1	0.455
1rx4	DDF	Dihydrofolate reductase	1.5.1.3	0.455
2c9d	PHR	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.455
2h44	7CA	cGMP-specific 3',5'-cyclic phosphodiesterase	/	0.455
2q66	ATP	Poly(A) polymerase	2.7.7.19	0.455
2yat	EEU	Estrogen receptor	/	0.455
3apw	DP0	Alpha-1-acid glycoprotein 2	/	0.455
3hub	469	Mitogen-activated protein kinase 14	/	0.455
3kp4	MII	Transcriptional regulator TcaR	/	0.455
3l9l	L9L	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.455
3mg3	ECH	Orange carotenoid-binding protein	/	0.455
3nmp	PYV	Abscisic acid receptor PYL2	/	0.455
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.455
4kjj	FOL	Dihydrofolate reductase	1.5.1.3	0.455
4knz	CB3	Thymidylate synthase	/	0.455
4lxj	LAN	Lanosterol 14-alpha demethylase	1.14.13.70	0.455
4mv1	ADP	Biotin carboxylase	6.3.4.14	0.455
4nmb	FAD	Bifunctional protein PutA	/	0.455
1ddu	CB3	Thymidylate synthase	/	0.454
1dgf	NDP	Catalase	1.11.1.6	0.454
1q66	KMB	Queuine tRNA-ribosyltransferase	2.4.2.29	0.454
2ivi	ACW	Isopenicillin N synthase	1.21.3.1	0.454
2z97	CAM	Camphor 5-monooxygenase	1.14.15.1	0.454
4bqp	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.454
4dfn	0K1	Tyrosine-protein kinase SYK	2.7.10.2	0.454
1hb1	OCV	Isopenicillin N synthase	1.21.3.1	0.453
1ppj	ANY	Cytochrome b	/	0.453
1syn	F89	Thymidylate synthase	/	0.453
1uy8	PU5	Heat shock protein HSP 90-alpha	/	0.453
1y2c	3DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.453
2f6r	ACO	Bifunctional coenzyme A synthase	/	0.453
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.453
2wey	EV1	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.453
2yke	YKE	Heat shock protein HSP 90-alpha	/	0.453
3dat	MTX	Dihydrofolate reductase	/	0.453
3l9m	L9M	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.453
3q9b	B3N	Acetylpolyamine amidohydrolase	/	0.453
4fhd	0TT	Spore photoproduct lyase	/	0.453
4fjz	4FJ	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.453
4jda	A9S	Abscisic acid receptor PYL3	/	0.453
1cg6	MTA	S-methyl-5'-thioadenosine phosphorylase	/	0.452
1lb9	DNQ	Glutamate receptor 2	/	0.452
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.452
1pl6	572	Sorbitol dehydrogenase	1.1.1.14	0.452
1xuz	MMN	Capsule biosynthesis protein	/	0.452
1zid	ZID	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.452
2ddo	ATP	Pyridoxine/pyridoxal/pyridoxamine kinase	/	0.452
2wuf	KEM	4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase	3.7.1.17	0.452
3itu	IBM	cGMP-dependent 3',5'-cyclic phosphodiesterase	3.1.4.17	0.452
4gkh	0J9	Aminoglycoside 3'-phosphotransferase AphA1-IAB	/	0.452
4isf	1FX	Glucokinase	2.7.1.2	0.452
4iyg	1HU	Strictosidine synthase	4.3.3.2	0.452
5a3c	NAD	SIR2 family protein	/	0.452
1aqu	EST	Estrogen sulfotransferase, testis isoform	2.8.2.4	0.451
1dna	CB3	Thymidylate synthase	/	0.451
2bbq	PFG	Thymidylate synthase	/	0.451
2fhj	H4Z	Formylmethanofuran--tetrahydromethanopterin formyltransferase	2.3.1.101	0.451
2pul	ACP	Methylthioribose kinase	2.7.1.100	0.451
2uxi	G50	HTH-type transcriptional regulator TtgR	/	0.451
2vcm	M11	Isopenicillin N synthase	1.21.3.1	0.451
3h03	UBP	Glutamate receptor 2	/	0.451
4a51	DQ8	Kinesin-like protein KIF11	/	0.451
4dsb	A8S	Abscisic acid receptor PYL3	/	0.451
4lrr	CF9	Thymidylate synthase	/	0.451
4m48	21B	Sodium-dependent dopamine transporter	/	0.451
4p6w	MOF	Glucocorticoid receptor	/	0.451
4u0o	MTA	Lipoyl synthase 2	/	0.451
4s0v	SUV	Orexin receptor type 2	/	0.451
1jom	FFO	Dihydrofolate reductase	1.5.1.3	0.450
1lud	TRR	Dihydrofolate reductase	1.5.1.3	0.450
1nbm	ADP	ATP synthase subunit beta, mitochondrial	3.6.3.14	0.450
1p0p	BCH	Cholinesterase	3.1.1.8	0.450
1rx2	FOL	Dihydrofolate reductase	1.5.1.3	0.450
2nv6	ZID	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.450
2xtb	KRM	Adenosine kinase, putative	/	0.450
2y1o	T26	UDP-N-acetylmuramoylalanine--D-glutamate ligase	6.3.2.9	0.450
3fwj	CAM	Camphor 5-monooxygenase	1.14.15.1	0.450
3nx4	NAP	Putative oxidoreductase	/	0.450
3qyo	Q24	Dihydrofolate reductase	1.5.1.3	0.450
4b13	X25	Glycylpeptide N-tetradecanoyltransferase	/	0.450
4kw5	1W6	Decaprenylphosphoryl-beta-D-ribose oxidase	/	0.450
4oea	DHT	Androgen receptor	/	0.450
4u7w	NDP	MxaA	/	0.450
4xsv	C5P	Ethanolamine-phosphate cytidylyltransferase	2.7.7.14	0.450
5c6c	CMP	cGMP-dependent protein kinase 2	2.7.11.12	0.450
6cp4	CAM	Camphor 5-monooxygenase	1.14.15.1	0.450
1f4g	TP4	Thymidylate synthase	/	0.449
1iwj	CAM	Camphor 5-monooxygenase	1.14.15.1	0.449
1k7f	IAV	Tryptophan synthase alpha chain	/	0.449
1uml	FR4	Adenosine deaminase	3.5.4.4	0.449
1uy9	PU6	Heat shock protein HSP 90-alpha	/	0.449
1w06	W05	Isopenicillin N synthase	1.21.3.1	0.449
2b36	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.449
2on6	IMH	Purine nucleoside phosphorylase	2.4.2.1	0.449
2q70	DC8	Estrogen receptor	/	0.449
3ar4	TG1	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	3.6.3.8	0.449
3d8v	UD1	Bifunctional protein GlmU	/	0.449
3exh	TPP	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	1.2.4.1	0.449
3exh	TPP	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	1.2.4.1	0.449
3g4g	D71	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.449
3pjc	PJC	Tyrosine-protein kinase JAK3	2.7.10.2	0.449
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.449
3zy6	GFB	GDP-fucose protein O-fucosyltransferase 1	2.4.1.221	0.449
4a81	DXC	Major pollen allergen Bet v 1-A	/	0.449
4a99	MIY	TetX family tetracycline inactivation enzyme	/	0.449
4ajw	VWN	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	2.7.1.153	0.449
4bb6	HD1	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.449
4bfr	J82	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	2.7.1.153	0.449
4dpy	2P0	Mevalonate diphosphate decarboxylase	/	0.449
4dsc	A8S	Abscisic acid receptor PYL3	/	0.449
4m7v	RAR	Dihydrofolate reductase	/	0.449
4y1b	NAP	AntE	/	0.449
4yaw	2AM	NADPH--cytochrome P450 reductase	/	0.449
1b2l	NDC	Alcohol dehydrogenase	1.1.1.1	0.448
1uzw	CDH	Isopenicillin N synthase	1.21.3.1	0.448
1yrd	CAM	Camphor 5-monooxygenase	1.14.15.1	0.448
2hm9	TRR	Dihydrofolate reductase	1.5.1.3	0.448
2ntj	P1H	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.448
2zio	AYB	Pyrrolysine--tRNA ligase	/	0.448
3fr5	I4A	Fatty acid-binding protein, adipocyte	/	0.448
3kmy	D8Y	Beta-secretase 1	3.4.23.46	0.448
3nhp	HGZ	Ribosyldihydronicotinamide dehydrogenase [quinone]	/	0.448
3oew	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.448
3sr5	Q12	Dihydrofolate reductase	1.5.1.3	0.448
4h6z	ACO	Alpha-tubulin N-acetyltransferase 1	/	0.448
4hy6	FJ1	Heat shock protein HSP 90-alpha	/	0.448
4i5i	4I5	NAD-dependent protein deacetylase sirtuin-1	3.5.1	0.448
4iv2	1GR	Estrogen receptor	/	0.448
4k39	SAM	Anaerobic sulfatase-maturating enzyme	1.8.98	0.448
1e1n	FAD	NADPH:adrenodoxin oxidoreductase, mitochondrial	1.18.1.6	0.447
1gzu	NMN	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1	2.7.7.1	0.447
1t87	CAM	Camphor 5-monooxygenase	1.14.15.1	0.447
1uye	PU9	Heat shock protein HSP 90-alpha	/	0.447
1xpc	AIT	Estrogen receptor	/	0.447
2d0k	FOL	Dihydrofolate reductase	1.5.1.3	0.447
2j9g	ANP	Biotin carboxylase	6.3.4.14	0.447
3a1l	2CC	Cytochrome P450	/	0.447
3of2	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.447
3r5y	F42	Uncharacterized protein	/	0.447
3zu2	NAI	Enoyl-[acyl-carrier-protein] reductase [NADH]	/	0.447
4bft	ZVT	Pantothenate kinase	2.7.1.33	0.447
4iah	1DX	Alr2278 protein	/	0.447
4iui	1GQ	Estrogen receptor	/	0.447
4j7u	YTZ	Sepiapterin reductase	1.1.1.153	0.447
4xz3	COA	Acyl-CoA synthetase (NDP forming)	/	0.447
4y7c	NAP	NADPH--cytochrome P450 reductase	/	0.447
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.446
1n5v	NOM	ActVA 6 protein	/	0.446
1sd1	FMC	S-methyl-5'-thioadenosine phosphorylase	/	0.446
1upw	444	Oxysterols receptor LXR-beta	/	0.446
1xu9	CPS	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.446
1y2e	5DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.446
1zp4	C2F	5,10-methylenetetrahydrofolate reductase	1.5.1.20	0.446
2cd8	PXI	Cytochrome P450 monooxygenase PikC	/	0.446
2gv8	FAD	Thiol-specific monooxygenase	1.14.13	0.446
2qk8	MTX	Dihydrofolate reductase	/	0.446
2xwe	AMF	Glucosylceramidase	3.2.1.45	0.446
2y37	A54	Nitric oxide synthase, inducible	1.14.13.39	0.446
2y60	M8F	Isopenicillin N synthase	1.21.3.1	0.446
3gwf	NAP	Cyclohexanone monooxygenase	/	0.446
3hz1	42C	Heat shock protein HSP 90-alpha	/	0.446
3lak	KR1	Gag-Pol polyprotein	2.7.7.49	0.446
3sn7	540	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.446
3ue4	DB8	Tyrosine-protein kinase ABL1	2.7.10.2	0.446
3vt9	YI4	Vitamin D3 receptor	/	0.446
3vws	VWS	Genome polyprotein	/	0.446
4b1f	KRH	Glutamate racemase	/	0.446
4g3r	CAM	Camphor 5-monooxygenase	1.14.15.1	0.446
1ayp	INB	Phospholipase A2, membrane associated	/	0.445
1cbq	RE9	Cellular retinoic acid-binding protein 2	/	0.445
1dz6	CAM	Camphor 5-monooxygenase	1.14.15.1	0.445
1jpa	ANP	Ephrin type-B receptor 2	2.7.10.1	0.445
1o9b	NAI	Quinate/shikimate dehydrogenase	/	0.445
1psd	NAD	D-3-phosphoglycerate dehydrogenase	1.1.1.95	0.445
1t13	INI	6,7-dimethyl-8-ribityllumazine synthase 2	/	0.445
1t86	CAM	Camphor 5-monooxygenase	1.14.15.1	0.445
1ysx	4EB	Serum albumin	/	0.445
1z6t	ADP	Apoptotic protease-activating factor 1	/	0.445
1zkn	IBM	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.445
2cle	F6F	Tryptophan synthase alpha chain	/	0.445
2iya	ZIO	Oleandomycin glycosyltransferase	/	0.445
2reh	FAD	Nitroalkane oxidase	1.7.3.1	0.445
2w6o	OA3	Biotin carboxylase	6.3.4.14	0.445
2w6z	L21	Biotin carboxylase	6.3.4.14	0.445
3bgr	T27	Gag-Pol polyprotein	2.7.7.49	0.445
3c14	FOK	Adenylate cyclase type 2	/	0.445
3c14	FOK	Adenylate cyclase type 5	/	0.445
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.445
3pqb	VGP	Putative oxidoreductase	/	0.445
3rbq	GLY_ALA_GLY_ALA_DAO	Protein unc-119 homolog A	/	0.445
3vt8	YI3	Vitamin D3 receptor	/	0.445
3zoi	M2W	Isopenicillin N synthase	1.21.3.1	0.445
4bbh	NHW	Glycylpeptide N-tetradecanoyltransferase	/	0.445
4bch	T7Z	Cyclin-dependent kinase 9	2.7.11.22	0.445
4fad	0TB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.445
4mv4	ACP	Biotin carboxylase	6.3.4.14	0.445
4nh8	2LC	Heat shock protein HSP 90-alpha	/	0.445
4rra	A3T	Probable threonine--tRNA ligase 2	6.1.1.3	0.445
4wfr	2AM	2',3'-cyclic-nucleotide 3'-phosphodiesterase	3.1.4.37	0.445
1pkf	EPD	Epothilone C/D epoxidase	1.14	0.444
1s1w	UC1	Gag-Pol polyprotein	2.7.7.49	0.444
1siq	FAD	Glutaryl-CoA dehydrogenase, mitochondrial	1.3.8.6	0.444
1tdu	DUR	Thymidylate synthase	/	0.444
1xon	PIL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.444
2f2u	M77	Rho-associated protein kinase 2	2.7.11.1	0.444
2fsz	OHT	Estrogen receptor beta	/	0.444
2g44	T3O	Estrogen receptor	/	0.444
2ghl	LIB	Mitogen-activated protein kinase 14	/	0.444
2h55	DZ8	Heat shock protein HSP 90-alpha	/	0.444
2j9l	ATP	H(+)/Cl(-) exchange transporter 5	/	0.444
2wue	KEK	4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase	3.7.1.17	0.444
2xvi	FAD	Putative flavin-containing monooxygenase	/	0.444
2yne	YNE	Glycylpeptide N-tetradecanoyltransferase	/	0.444
3a3y	OBN	Sodium/potassium-transporting ATPase subunit alpha	/	0.444
3g45	988	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.444
3gc8	B45	Mitogen-activated protein kinase 11	2.7.11.24	0.444
3iqf	E4M	F420-dependent methylenetetrahydromethanopterin dehydrogenase	1.5.98.1	0.444
3sni	546	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.444
3srr	Q20	Dihydrofolate reductase	1.5.1.3	0.444
3t5i	SER_SER_CMT_FAR	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	/	0.444
3w78	CBD	FMN-dependent NADH-azoreductase	/	0.444
3wv9	FEG	Hmd co-occurring protein HcgE	/	0.444
4ajm	3A6	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.444
4c3y	ANB	3-ketosteroid dehydrogenase	/	0.444
4czt	CPS	CBL-interacting serine/threonine-protein kinase 23	2.7.11.1	0.444
4ho5	DAU	Glucose-1-phosphate thymidylyltransferase	/	0.444
4i6f	1C7	Serine/threonine-protein kinase PLK2	2.7.11.21	0.444
5d7p	OCZ	NAD-dependent protein deacetylase sirtuin-2	3.5.1	0.444
1ek2	CDU	Bifunctional epoxide hydrolase 2	/	0.443
1eny	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.443
1f20	FAD	Nitric oxide synthase, brain	1.14.13.39	0.443
1ove	358	Mitogen-activated protein kinase 14	/	0.443
1sr7	MOF	Progesterone receptor	/	0.443
2aqk	NAI	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.443
2o7p	NAP	Riboflavin biosynthesis protein RibD	/	0.443
2uxo	TAC	HTH-type transcriptional regulator TtgR	/	0.443
2vte	IK4	UDP-N-acetylmuramoylalanine--D-glutamate ligase	6.3.2.9	0.443
2ydv	NEC	Adenosine receptor A2a	/	0.443
3d84	NDP	Dihydrofolate reductase	1.5.1.3	0.443
3fra	I2H	Dihydrofolate reductase	1.5.1.3	0.443
3inx	JZC	Heat shock protein HSP 90-alpha	/	0.443
3l8s	BFF	Mitogen-activated protein kinase 14	/	0.443
3lan	KBT	Gag-Pol polyprotein	2.7.7.49	0.443
3o73	O73	Ribosyldihydronicotinamide dehydrogenase [quinone]	/	0.443
3p8i	FMN	Pentaerythritol tetranitrate reductase	/	0.443
3u8h	BHP	Phospholipase A2, membrane associated	/	0.443
3w6h	AZM	Carbonic anhydrase 1	4.2.1.1	0.443
4awo	99B	Heat shock protein HSP 90-alpha	/	0.443
4eso	NAP	Putative oxidoreductase	/	0.443
4gev	CB3	Thymidylate synthase	/	0.443
4k37	SAM	Anaerobic sulfatase-maturating enzyme	1.8.98	0.443
4wh2	ADP	N-acetylhexosamine 1-kinase	2.7.1.162	0.443
5ab6	CAA	Nonspecific lipid-transfer protein, putative	/	0.443
1dhi	MTX	Dihydrofolate reductase	1.5.1.3	0.442
1hdc	CBO	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	1.1.1.53	0.442
1hnv	TBO	Gag-Pol polyprotein	2.7.7.49	0.442
1icq	OPD	12-oxophytodienoate reductase 1	1.3.1.42	0.442
1l2j	ETC	Estrogen receptor beta	/	0.442
1noo	CAH	Camphor 5-monooxygenase	1.14.15.1	0.442
1qxl	FR8	Adenosine deaminase	3.5.4.4	0.442
1uy7	PU4	Heat shock protein HSP 90-alpha	/	0.442
1x8l	OXR	Retinol dehydratase	/	0.442
1xoq	ROF	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.442
1yqj	6NP	Mitogen-activated protein kinase 14	/	0.442
2aqh	NAI	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.442
2ay3	MPP	Aromatic-amino-acid aminotransferase	2.6.1.57	0.442
2vn0	TDZ	Cytochrome P450 2C8	/	0.442
2xvv	9DN	Serum albumin	/	0.442
2ykj	YKJ	Heat shock protein HSP 90-alpha	/	0.442
2z7g	EH9	Adenosine deaminase	3.5.4.4	0.442
3ada	NAD	Subunit alpha of sarocosine oxidase	/	0.442
3fwf	CAM	Camphor 5-monooxygenase	1.14.15.1	0.442
3iqz	H4M	F420-dependent methylenetetrahydromethanopterin dehydrogenase	1.5.98.1	0.442
3jpv	1DR	Serine/threonine-protein kinase pim-1	2.7.11.1	0.442
3nhr	RZW	Ribosyldihydronicotinamide dehydrogenase [quinone]	/	0.442
4anu	EM7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.442
4cuk	NAI	D-lactate dehydrogenase	/	0.442
4fa6	0TA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.442
4lht	CNL	1,8-cineole 2-endo-monooxygenase	1.14.13.156	0.442
4x28	FDA	Acyl-CoA dehydrogenase FadE26	/	0.442
4x28	FDA	Acyl-CoA dehydrogenase FadE27	/	0.442
5dn1	AMZ	Phosphoribosyl isomerase A	5.3.1.16	0.442
1db5	6IN	Phospholipase A2, membrane associated	/	0.441
1dcy	I3N	Phospholipase A2, membrane associated	/	0.441
1ml6	GBX	Glutathione S-transferase A2	2.5.1.18	0.441
1qjf	ACS	Isopenicillin N synthase	1.21.3.1	0.441
1ri1	GTG	mRNA cap guanine-N7 methyltransferase	2.1.1.56	0.441
1soj	IBM	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	3.1.4.17	0.441
2fs4	PZ1	Renin	3.4.23.15	0.441
2fvl	NAP	Aldo-keto reductase family 1 member C4	1.1.1.225	0.441
2nr4	FMN	Conserved protein	/	0.441
2o12	FMN	Chorismate synthase	/	0.441
2q9f	C3S	Cholesterol 24-hydroxylase	/	0.441
2qgt	EED	Estrogen receptor	/	0.441
2v58	LZJ	Biotin carboxylase	6.3.4.14	0.441
2w4q	CBW	Prostaglandin reductase 2	1.3.1.48	0.441
2wgj	VGH	Hepatocyte growth factor receptor	2.7.10.1	0.441
2xiq	5AD	Methylmalonyl-CoA mutase, mitochondrial	/	0.441
2z4w	749	Geranylgeranyl pyrophosphate synthase	/	0.441
3c0g	3AM	Peripheral plasma membrane protein CASK	2.7.11.1	0.441
3cqe	P91	Wee1-like protein kinase	2.7.10.2	0.441
3fr4	F8A	Fatty acid-binding protein, adipocyte	/	0.441
3ha3	SAH	Hydroxymycolate synthase MmaA4	2.1.1	0.441
3iel	U5P	Ribonuclease TTHA0252	3.1	0.441
3iw4	LW4	Protein kinase C alpha type	2.7.11.13	0.441
3lfe	Z84	Mitogen-activated protein kinase 14	/	0.441
3nfr	EWQ	Ribosyldihydronicotinamide dehydrogenase [quinone]	/	0.441
3s79	ASD	Aromatase	1.14.14.14	0.441
3x2f	NAI	Adenosylhomocysteinase	/	0.441
4asy	N5Y	Glucose-1-phosphate thymidylyltransferase	/	0.441
4bbx	LKF	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.441
4hf4	15H	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.441
4ivy	1GT	Estrogen receptor	/	0.441
4jlj	1NM	Deoxycytidine kinase	2.7.1.74	0.441
4lm5	Q17	Serine/threonine-protein kinase pim-1	2.7.11.1	0.441
4qer	STL	Phospholipase A2 VRV-PL-VIIIa	/	0.441
4udc	DEX	Glucocorticoid receptor	/	0.441
1dlr	MXA	Dihydrofolate reductase	1.5.1.3	0.440
1xp6	AIU	Estrogen receptor	/	0.440
2a1n	CAM	Camphor 5-monooxygenase	1.14.15.1	0.440
2b37	8PS	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.440
2bik	BI1	Serine/threonine-protein kinase pim-1	2.7.11.1	0.440
2brm	DFZ	Serine/threonine-protein kinase Chk1	2.7.11.1	0.440
2ieb	ZID	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.440
2qo5	CHD	Fatty acid-binding protein 10-A, liver basic	/	0.440
2w8y	NDR	Progesterone receptor	/	0.440
3anl	SYC	1-deoxy-D-xylulose 5-phosphate reductoisomerase	1.1.1.267	0.440
3c1t	MYC	Dihydroflavonol 4-reductase	1.1.1.219	0.440
3gmd	2M3	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.440
3jun	AKD	Phenazine biosynthesis protein A/B	/	0.440
3n63	XFN	Nitric oxide synthase, brain	1.14.13.39	0.440
4a9m	P9M	Bromodomain-containing protein 2	/	0.440
4elh	53I	Dihydrofolate reductase	/	0.440
4fsa	0V3	Queuine tRNA-ribosyltransferase	2.4.2.29	0.440
4gi4	0EX	Queuine tRNA-ribosyltransferase	2.4.2.29	0.440
4h4o	506	Gag-Pol polyprotein	2.7.7.49	0.440
4iw8	KN3	Estrogen receptor	/	0.440
4l6g	CNL	1,8-cineole 2-endo-monooxygenase	1.14.13.156	0.440
4lsj	LSJ	Glucocorticoid receptor	/	0.440
4ug9	1EW	Nitric oxide synthase oxygenase	1.14.13.165	0.440
4z63	ILE_THR_GLN_TYS_TYS	Phytosulfokine receptor 1	2.7.11.1	0.440
3uza	T4G	Adenosine receptor A2a	/	0.440