sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.831 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.828 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.819 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.764 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.755 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.742 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.733 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.714 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.712 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.708 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.696 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.690 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.681 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.671 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.671 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.667 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.656 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.653 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.647 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.646 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.646 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.645 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.645 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.644 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.644 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.643 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.641 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.638 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.635 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.635 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.634 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.634 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.631 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.629 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.629 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.627 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.625 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.623 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.621 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.619 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.618 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.616 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.614 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.613 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.612 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.610 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.607 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.605 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.602 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.602 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.598 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.586 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.580 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.577 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.569 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.533 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.513 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.509 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.508 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.507 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.502 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.500 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.494 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.493 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.485 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.485 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.484 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.481 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.481 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.480 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.476 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.476 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.476 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.475 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.473 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.472 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.471 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.471 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.471 | |
| 5bmv | VLB | Tubulin alpha-1B chain | / | 0.471 | |
| 5bmv | VLB | Tubulin beta chain | / | 0.471 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.470 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.470 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.468 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.467 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.467 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.467 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.466 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.466 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.465 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.465 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.464 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.463 | |
| 3nxu | RIT | Cytochrome P450 3A4 | / | 0.462 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.461 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.461 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.460 | |
| 3aid | ARQ | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 3au8 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.460 | |
| 4ylf | FAD | Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog | / | 0.460 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.458 | |
| 2y4g | TIR | TamL | / | 0.458 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.458 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.457 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.457 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.456 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.456 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.456 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.456 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.456 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.456 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.456 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.456 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.455 | |
| 1np7 | FAD | Cryptochrome DASH | / | 0.455 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 5c7o | NAD | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific | 1.2.1.12 | 0.455 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.454 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.454 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.454 | |
| 2vtb | FAD | Cryptochrome DASH, chloroplastic/mitochondrial | / | 0.453 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1xl2 | 189 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 4egn | TWO | Cytochrome P450 | / | 0.452 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.452 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 4aw3 | MYV | Mycinamicin IV hydroxylase/epoxidase | / | 0.451 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.451 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.450 | |
| 2wpx | ACO | Orf14 | / | 0.450 | |
| 3eej | 53R | Uncharacterized protein | / | 0.450 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.450 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.450 | |
| 3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.450 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.449 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.449 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.449 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.449 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.448 | |
| 2y3r | TIR | TamL | / | 0.448 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.448 | |
| 4b99 | R4L | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.448 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.447 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1dss | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.446 | |
| 3fln | 3FN | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.446 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2y3r | TRK | TamL | / | 0.445 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.445 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.445 | |
| 1tez | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.444 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.444 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.444 | |
| 2vgo | AD5 | Aurora kinase B-A | 2.7.11.1 | 0.444 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.444 | |
| 3flz | FLZ | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3gob | HXX | DdmC | / | 0.444 | |
| 3kf7 | L9G | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 4fob | 0US | ALK tyrosine kinase receptor | 2.7.10.1 | 0.444 | |
| 4nm9 | FAD | Bifunctional protein PutA | / | 0.444 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.444 | |
| 1zmd | NAI | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.443 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.443 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3fly | FLY | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3ids | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.443 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.443 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.443 | |
| 3zuy | TCH | Transporter | / | 0.443 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.443 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.443 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.442 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.442 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.442 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.442 | |
| 4mvf | STU | Calcium-dependent protein kinase 2 | 2.7.11.1 | 0.442 | |
| 1owm | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.441 | |
| 1owp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.441 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 1zz2 | B11 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.441 | |
| 4kbk | 1QG | Casein kinase I isoform delta | 2.7.11.1 | 0.441 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.441 | |
| 4o59 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.441 | |
| 1own | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.440 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.440 | |
| 2j0d | ERY | Cytochrome P450 3A4 | / | 0.440 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 2z0y | SAM | Ribosomal RNA small subunit methyltransferase E | / | 0.440 | |
| 3eya | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.440 | |
| 3p79 | P79 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.440 | |
| 4a9h | TVP | Bromodomain-containing protein 2 | / | 0.440 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.440 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 |