scPDB - Distribution of Binding site Similarity values of 1isg entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1isg	AGS	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2	3.2.2.6

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1isg	AGS	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2	3.2.2.6	1.000
1kyx	CRM	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.504
2i65	NAD	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	3.2.2.6	0.488
4lcw	1VY	Major histocompatibility complex class I-related gene protein	/	0.476
2a59	LMZ	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.475
2a57	CRM	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.472
4b13	X25	Glycylpeptide N-tetradecanoyltransferase	/	0.472
2xys	SY9	Soluble acetylcholine receptor	/	0.471
2y1w	849	Histone-arginine methyltransferase CARM1	/	0.471
1ut6	A8N	Acetylcholinesterase	3.1.1.7	0.470
2vrj	NCW	Beta-glucosidase A	3.2.1.21	0.469
2zu9	GDP	Mannosyl-3-phosphoglycerate synthase	2.4.1.217	0.466
4a95	9MT	Glycylpeptide N-tetradecanoyltransferase	/	0.466
4b12	C23	Glycylpeptide N-tetradecanoyltransferase	/	0.466
4kq6	DLZ	6,7-dimethyl-8-ribityllumazine synthase	/	0.466
1nqu	RDL	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.465
1tco	FK5	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.464
1tco	FK5	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	3.1.3.16	0.464
1ycf	FMN	Nitric oxide reductase	1	0.464
2tpl	HPP	Tyrosine phenol-lyase	4.1.99.2	0.464
3zj7	C1K	Strictosidine-O-beta-D-glucosidase	3.2.1.105	0.464
5a4v	QUE	Glutathione S-transferase F2	2.5.1.18	0.463
2ipi	AKY	Aclacinomycin-N/aclacinomycin-A oxidase	/	0.462
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.462
4hhy	15R	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.462
2yne	YNE	Glycylpeptide N-tetradecanoyltransferase	/	0.461
1isj	NMN	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2	3.2.2.6	0.460
1lnm	DTX	Bilin-binding protein	/	0.460
3bur	TES	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.460
4b11	7I1	Glycylpeptide N-tetradecanoyltransferase	/	0.460
2aot	2PM	Histamine N-methyltransferase	2.1.1.8	0.459
4b14	4XB	Glycylpeptide N-tetradecanoyltransferase	/	0.459
4gv4	MEJ	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.459
3aiv	HBO	4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic	3.2.1.182	0.458
1kyv	RBF	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.457
3dz4	C8M	S-adenosylmethionine decarboxylase proenzyme	4.1.1.50	0.457
3to3	ATP	Petrobactin biosynthesis protein AsbB	/	0.457
4a32	2CD	Glycylpeptide N-tetradecanoyltransferase	/	0.456
4r5w	XAV	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.456
2a3b	CFF	Endochitinase B1	3.2.1.14	0.455
4drj	RAP	Serine/threonine-protein kinase mTOR	2.7.11.1	0.455
4drj	RAP	Peptidyl-prolyl cis-trans isomerase FKBP4	5.2.1.8	0.455
5dsy	UHB	Poly [ADP-ribose] polymerase 2	2.4.2.30	0.455
2b8j	ADN	Class B acid phosphatase	3.1.3.2	0.454
3ggs	2FD	Purine nucleoside phosphorylase	2.4.2.1	0.454
4e2z	JHZ	Methyltransferase	/	0.454
1i5r	HYC	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.453
1pax	DHQ	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.453
2nmt	MIM	Glycylpeptide N-tetradecanoyltransferase	2.3.1.97	0.453
4gv0	8ME	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.453
4j7h	TRH	PCZA361.3	/	0.453
4tvj	09L	Poly [ADP-ribose] polymerase 2	2.4.2.30	0.453
2xup	TZ5	Acetylcholinesterase	3.1.1.7	0.452
3gjw	GJW	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.452
4c2z	646	Glycylpeptide N-tetradecanoyltransferase 1	/	0.452
1efy	BZC	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.451
1eko	I84	Aldose reductase	1.1.1.21	0.451
2g1a	5HG	Class B acid phosphatase	3.1.3.2	0.451
3buv	NAP	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.451
3nyt	ULP	UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase	2.6.1.98	0.451
4heu	15J	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.451
1aqu	EST	Estrogen sulfotransferase, testis isoform	2.8.2.4	0.450
1hb3	SCV	Isopenicillin N synthase	1.21.3.1	0.450
1ry0	PG2	Aldo-keto reductase family 1 member C3	/	0.450
1xoq	ROF	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.450
4fam	0SZ	Aldo-keto reductase family 1 member C3	/	0.450
4nzh	FAD	L-ornithine N(5)-monooxygenase	/	0.450
1ld7	U66	Protein farnesyltransferase subunit beta	2.5.1.58	0.449
1rkw	PNT	HTH-type transcriptional regulator QacR	/	0.449
4hhz	15S	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.449
5d6l	CAU	Beta-2 adrenergic receptor	/	0.449
1fap	RAP	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.448
1fap	RAP	Serine/threonine-protein kinase mTOR	2.7.11.1	0.448
1rpw	DID	HTH-type transcriptional regulator QacR	/	0.448
2v2z	CDM	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	/	0.448
3e4a	QIX	Insulin-degrading enzyme	3.4.24.56	0.448
4glx	0XS	DNA ligase	6.5.1.2	0.448
1uk0	FRM	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.447
2vbp	VB1	Isopenicillin N synthase	1.21.3.1	0.447
2zev	IPE	Geranylgeranyl pyrophosphate synthase	/	0.447
2zrv	FNR	Isopentenyl-diphosphate delta-isomerase	/	0.447
3c49	KU8	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.447
4rxp	DTP	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	3.1.5	0.447
5cho	FAD	Flavin reductase	/	0.447
4u14	0HK	Muscarinic acetylcholine receptor M3	/	0.447
1q83	TZ5	Acetylcholinesterase	3.1.1.7	0.446
1ry8	RUT	Aldo-keto reductase family 1 member C3	/	0.446
4a86	H35	Major pollen allergen Bet v 1-A	/	0.446
5cxv	0HK	Muscarinic acetylcholine receptor M1	/	0.446
1e1f	PSG	4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic	3.2.1.182	0.445
1k4m	NAD	Nicotinate-nucleotide adenylyltransferase	2.7.7.18	0.445
1z5u	CMP	Class B acid phosphatase	/	0.445
2ha6	SCK	Acetylcholinesterase	3.1.1.7	0.445
2iej	S48	Protein farnesyltransferase subunit beta	2.5.1.58	0.445
3fap	ARD	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.445
3fap	ARD	Serine/threonine-protein kinase mTOR	2.7.11.1	0.445
3l3l	L3L	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.445
4to1	DCP	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	3.1.5	0.445
4x28	FDA	Acyl-CoA dehydrogenase FadE26	/	0.445
4x28	FDA	Acyl-CoA dehydrogenase FadE27	/	0.445
1q84	TZ4	Acetylcholinesterase	3.1.1.7	0.444
2c1z	KMP	Anthocyanidin 3-O-glucosyltransferase 2	2.4.1.115	0.444
2g28	TDK	Pyruvate dehydrogenase E1 component	1.2.4.1	0.444
2rcw	AAI	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.444
3euf	BAU	Uridine phosphorylase 1	/	0.444
3nub	UD0	UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase	2.6.1.98	0.444
3p0f	BAU	Uridine phosphorylase 2	2.4.2.3	0.444
3s5w	FAD	L-ornithine N(5)-monooxygenase	/	0.444
4bbh	YBN	Glycylpeptide N-tetradecanoyltransferase	/	0.444
4e2y	JHZ	Methyltransferase	/	0.444
2zrx	FMN	Isopentenyl-diphosphate delta-isomerase	/	0.443
2zry	FNR	Isopentenyl-diphosphate delta-isomerase	/	0.443
3c4h	DRL	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.443
4phl	PIL	Phosphodiesterase	/	0.443
4tnz	TTP	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	3.1.5	0.443
4uug	PXG	Branched-chain amino acid aminotransferase, putative	/	0.443
1dig	L37	C-1-tetrahydrofolate synthase, cytoplasmic	1.5.1.5	0.442
1nsg	RAD	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.442
1nsg	RAD	Serine/threonine-protein kinase mTOR	2.7.11.1	0.442
1u65	CP0	Acetylcholinesterase	3.1.1.7	0.442
1xf0	ASD	Aldo-keto reductase family 1 member C3	/	0.442
2xuk	TZ5	Acetylcholinesterase	3.1.1.7	0.442
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.442
4tny	DGT	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	3.1.5	0.442
1kyy	INI	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.441
2b82	ADN	Class B acid phosphatase	3.1.3.2	0.441
2cmf	F11	Acetylcholinesterase	3.1.1.7	0.441
2g8y	NAD	Hydroxycarboxylate dehydrogenase B	/	0.441
2j3q	TFL	Acetylcholinesterase	3.1.1.7	0.441
2xuj	TZ5	Acetylcholinesterase	3.1.1.7	0.441
3qgi	33F	Genome polyprotein	2.7.7.48	0.441
3u57	DH8	Raucaffricine-O-beta-D-glucosidase	3.2.1.125	0.441
4to4	DCP	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	3.1.5	0.441
1pj6	FOL	Dimethylglycine oxidase	1.5.3.10	0.440
2rd2	QSI	Glutamine--tRNA ligase	6.1.1.18	0.440
2vi5	Y19	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.440
3b9o	FMN	Alkane monoxygenase	/	0.440
3br3	ET	HTH-type transcriptional regulator QacR	/	0.440
3v94	WYQ	Phosphodiesterase	/	0.440
4mr7	2BV	Gamma-aminobutyric acid type B receptor subunit 1	/	0.440
4nwi	CTN	7-methylguanosine phosphate-specific 5'-nucleotidase	/	0.440
3ny9	JSZ	Beta-2 adrenergic receptor	/	0.440