sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1ih7 | GMP | DNA-directed DNA polymerase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1ih7 | GMP | DNA-directed DNA polymerase | / | 1.000 | |
| 1clq | GDP | DNA-directed DNA polymerase | / | 0.648 | |
| 4i9q | XG4 | DNA-directed DNA polymerase | / | 0.599 | |
| 1waj | 5GP | DNA-directed DNA polymerase | / | 0.595 | |
| 3cfo | GMP | DNA-directed DNA polymerase | / | 0.549 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.504 | |
| 3koz | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.503 | |
| 4nv0 | MG7 | 7-methylguanosine phosphate-specific 5'-nucleotidase | / | 0.502 | |
| 3koy | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.497 | |
| 3x02 | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.496 | |
| 3lpg | Z78 | Beta-glucuronidase | 3.2.1.31 | 0.486 | |
| 2clh | F19 | Tryptophan synthase alpha chain | / | 0.485 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.485 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.484 | |
| 3x0a | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.479 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.478 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.477 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.476 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.476 | |
| 2b82 | ADN | Class B acid phosphatase | 3.1.3.2 | 0.475 | |
| 4ccq | NAP | Thioredoxin reductase | / | 0.475 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.474 | |
| 3kp0 | Z98 | D-ornithine 4,5-aminomutase subunit beta | / | 0.472 | |
| 4gt8 | ADP | Sensor protein VraS | 2.7.13.3 | 0.472 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.471 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.469 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.469 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.468 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.468 | |
| 3lpf | Z77 | Beta-glucuronidase | 3.2.1.31 | 0.468 | |
| 4lez | 1SY | Cyclic GMP-AMP synthase | / | 0.468 | |
| 4ysw | NAI | Xanthine dehydrogenase/oxidase | / | 0.468 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.467 | |
| 3b5i | SAH | Indole-3-acetate O-methyltransferase 1 | / | 0.467 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.467 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.467 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.466 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1xmm | M7G | m7GpppX diphosphatase | 3.6.1.59 | 0.464 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.464 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.464 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.464 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.464 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.463 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.463 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.463 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.463 | |
| 2qmz | LDP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.462 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.462 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.462 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.460 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.460 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.460 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.460 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.460 | |
| 4ivq | I43 | Thymidine kinase | / | 0.460 | |
| 4khn | XG4 | DNA-directed DNA polymerase | / | 0.460 | |
| 1ra2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.459 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.459 | |
| 4nwi | CTN | 7-methylguanosine phosphate-specific 5'-nucleotidase | / | 0.459 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.458 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.458 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2e94 | 364 | Geranylgeranyl pyrophosphate synthase | / | 0.457 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.457 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.457 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.457 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.457 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.457 | |
| 2v8p | CDP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.456 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.456 | |
| 3o9p | MHI | Periplasmic murein peptide-binding protein | / | 0.456 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.456 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.456 | |
| 4rtj | SFG | DNA adenine methylase | 2.1.1.72 | 0.456 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.455 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.455 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3bgr | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 3n10 | CMP | Adenylate cyclase 2 | / | 0.455 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.455 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.454 | |
| 3jqg | AX6 | Pteridine reductase, putative | / | 0.454 | |
| 3sc1 | 3S1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.454 | |
| 3v0m | 5GW | Histo-blood group ABO system transferase | / | 0.454 | |
| 4fev | PP1 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.454 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2oal | FAD | Flavin-dependent tryptophan halogenase RebH | 1.14.19.9 | 0.453 | |
| 2owb | 626 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.453 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.453 | |
| 3ntd | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.453 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.453 | |
| 1dlj | UGA | UDP-glucose 6-dehydrogenase | / | 0.452 | |
| 1fxf | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.452 | |
| 1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.452 | |
| 1rp4 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.452 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.452 | |
| 2jgb | MGT | Eukaryotic translation initiation factor 4E type 2 | / | 0.452 | |
| 2qtr | NXX | Probable nicotinate-nucleotide adenylyltransferase | / | 0.452 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.452 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.452 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.452 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.452 | |
| 4kc1 | WS1 | Histo-blood group ABO system transferase | / | 0.452 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.452 | |
| 1k4g | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.451 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.451 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.451 | |
| 3nta | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.451 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.451 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.451 | |
| 4zas | TYD | CalS13 | / | 0.451 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.450 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.450 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.450 | |
| 2qta | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.450 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.450 | |
| 3rl4 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.450 | |
| 3x0c | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.450 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4wzy | ATP | Maltokinase | 2.7.1.175 | 0.450 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1e2n | RCA | Thymidine kinase | / | 0.449 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.449 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 2iyi | FMN | AppA, antirepressor of ppsR, sensor of blue light | / | 0.449 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.449 | |
| 3q2j | CKI | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.449 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.448 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.448 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.448 | |
| 3zdf | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.448 | |
| 4gh3 | 0EV | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.448 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.448 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 2z1w | BDI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.447 | |
| 3mes | PT3 | Putative choline kinase | / | 0.447 | |
| 3mfl | DHY | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.447 | |
| 3mfl | DHY | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.447 | |
| 3n0y | APC | Adenylate cyclase 2 | / | 0.447 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4k97 | ATP | Cyclic GMP-AMP synthase | / | 0.447 | |
| 4l23 | X6K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | / | 0.447 | |
| 4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.447 | |
| 1e2j | THM | Thymidine kinase | / | 0.446 | |
| 1hk4 | T44 | Serum albumin | / | 0.446 | |
| 2v1a | FMN | NPH1-1 | / | 0.446 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 2web | PP4 | Penicillopepsin-1 | 3.4.23.20 | 0.446 | |
| 2zi5 | 3L1 | Deoxycytidine kinase | 2.7.1.74 | 0.446 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4m52 | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.446 | |
| 4yus | FMN | Family 3 adenylate cyclase | / | 0.446 | |
| 1odj | GMP | Purine nucleoside phosphorylase | / | 0.445 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.445 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.445 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4bdr | KAI | Glutamate receptor ionotropic, kainate 2 | / | 0.445 | |
| 4wct | FAD | Fructosyl amine:oxygen oxidoreductase | / | 0.445 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.445 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.444 | |
| 2xkf | BX1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.444 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.444 | |
| 3d5w | ADP | Serine/threonine-protein kinase PLK | / | 0.444 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.444 | |
| 5kbw | RBF | Riboflavin transporter RibU | / | 0.444 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1njj | ORX | Ornithine decarboxylase | / | 0.443 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2v2q | NVG | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.443 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 3lfz | ADP | Uncharacterized protein MJ1225 | / | 0.443 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.443 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.443 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4g8c | C6L | Alpha/beta hydrolase fold protein | / | 0.443 | |
| 4jbx | SK7 | Thymidine kinase | / | 0.443 | |
| 4uof | DAT | Nucleoside diphosphate kinase | / | 0.443 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1oj4 | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.442 | |
| 1pag | FMP | Antiviral protein I | 3.2.2.22 | 0.442 | |
| 1qcf | PP1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.442 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2amb | 17H | Androgen receptor | / | 0.442 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.442 | |
| 3tp0 | FO5 | HTH-type transcriptional regulator EthR | / | 0.442 | |
| 3u8d | U8D | Phospholipase A2, membrane associated | / | 0.442 | |
| 4aw0 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 5c8d | 5AD | Probable transcriptional regulator | / | 0.442 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.442 | |
| 1knp | FAD | L-aspartate oxidase | 1.4.3.16 | 0.441 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 1zap | A70 | Candidapepsin-2 | 3.4.23.24 | 0.441 | |
| 1zyd | ATP | eIF-2-alpha kinase GCN2 | / | 0.441 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3fu8 | 3DM | Laccase-1 | 1.10.3.2 | 0.441 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 3uk6 | ADP | RuvB-like 2 | 3.6.4.12 | 0.441 | |
| 3vmm | P0D | Alanine--anticapsin ligase | / | 0.441 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4h3g | 10Q | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 5f54 | TMP | Single-stranded-DNA-specific exonuclease | / | 0.441 | |
| 5hq8 | SAH | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.441 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 1oon | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.440 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.440 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2dvo | ITT | dITP/XTP pyrophosphatase | 3.6.1.19 | 0.440 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 2par | TMP | 5'-deoxynucleotidase YfbR | / | 0.440 | |
| 2xvu | 9DN | Serum albumin | / | 0.440 | |
| 3blo | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.440 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.440 | |
| 3pre | 3RE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.440 | |
| 3wtk | TH4 | Acetylcholine-binding protein | / | 0.440 | |
| 3zdu | 38R | Cyclin-dependent kinase-like 3 | 2.7.11.22 | 0.440 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.440 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.440 |