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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ifuFMCRicin3.2.2.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1ifuFMCRicin3.2.2.221.000
4lwxMU2Ribosome inactivating protein/0.569
1ahbFMPRibosome-inactivating protein momordin I3.2.2.220.561
3qjiMGPRibosome inactivating protein/0.555
4emrMGPRibosome inactivating protein/0.552
5dsg0HKMuscarinic acetylcholine receptor M4/0.547
5cxv0HKMuscarinic acetylcholine receptor M1/0.540
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.523
1aquESTEstrogen sulfotransferase, testis isoform2.8.2.40.514
3uonQNBMuscarinic acetylcholine receptor M2/0.513
1ry0PG2Aldo-keto reductase family 1 member C3/0.512
4u150HKMuscarinic acetylcholine receptor M3/0.508
3hggCHDCmeR/0.507
1lpcCMPAntiviral protein DAP-303.2.2.220.505
4daj0HKMuscarinic acetylcholine receptor M3/0.503
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.502
4u163C0Muscarinic acetylcholine receptor M3/0.502
4stdBFSScytalone dehydratase4.2.1.940.501
4jvmXDIEstrogen sulfotransferase2.8.2.40.500
2y60M8FIsopenicillin N synthase1.21.3.10.499
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.498
4psbGA3Cytokinin-specific binding protein/0.497
3zc3FADFerredoxin--NADP reductase1.18.1.20.496
4li61XOTankyrase-12.4.2.300.495
2c9dPHR6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.494
1dgfNDPCatalase1.11.1.60.493
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.493
1obnASVIsopenicillin N synthase1.21.3.10.492
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.492
4b65NDPL-ornithine N(5)-monooxygenase/0.492
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.492
4dbw511Aldo-keto reductase family 1 member C3/0.492
4eyb0WOMetallo-beta-lactamase type 2/0.492
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.491
2bu9HFVIsopenicillin N synthase1.21.3.10.490
2qw8NAPEugenol synthase 11.1.1.3180.490
2wgs1AZGlutamine synthetase6.3.1.20.490
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.490
1pagFMPAntiviral protein I3.2.2.220.489
1uzwCDHIsopenicillin N synthase1.21.3.10.489
2f3815MAldo-keto reductase family 1 member C3/0.489
3hfbML4Tryptophan 5-hydroxylase 11.14.16.40.489
4bfxZVXPantothenate kinase2.7.1.330.489
4f79P53Putative phospho-beta-glucosidase/0.489
4jtpASCRibosome inactivating protein/0.489
3r7mSUZAldo-keto reductase family 1 member C3/0.488
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.487
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.487
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.487
3r43ID8Aldo-keto reductase family 1 member C3/0.486
3nxtD2EDihydrofolate reductase1.5.1.30.485
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.485
2qx7NAPEugenol synthase 11.1.1.3180.484
2hzqSTRApolipoprotein D/0.483
3hivTXNrRNA N-glycosidase/0.483
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.483
1zydATPeIF-2-alpha kinase GCN2/0.482
3c4hDRLPoly [ADP-ribose] polymerase 32.4.2.300.482
3fsjD7KBenzoylformate decarboxylase4.1.1.70.482
4ubuCOASteroid 3-ketoacyl-CoA thiolase/0.482
1gt5BZQOdorant-binding protein/0.481
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.481
4b64NAPL-ornithine N(5)-monooxygenase/0.481
4mdkU94Ubiquitin-conjugating enzyme E2 R1/0.481
1bk0ACVIsopenicillin N synthase1.21.3.10.480
1w29TS16,7-dimethyl-8-ribityllumazine synthase2.5.1.780.480
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.480
5stdUNNScytalone dehydratase4.2.1.940.480
2jb4A14Isopenicillin N synthase1.21.3.10.479
3szfDCQSulfide-quinone reductase/0.479
3zkyWT4Isopenicillin N synthase1.21.3.10.478
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.478
4iktTFVMethionine aminopeptidase 1/0.478
4jq3ZOMAldo-keto reductase family 1 member C2/0.478
1w19T4P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.477
2cekN8TAcetylcholinesterase3.1.1.70.477
2vi5Y196,7-dimethyl-8-ribityllumazine synthase2.5.1.780.477
3f3y4OABile salt sulfotransferase2.8.2.140.477
4jbxSK7Thymidine kinase/0.477
1lnmDTXBilin-binding protein/0.476
1nj6A5AProline--tRNA ligase/0.476
1ohkCOPDihydrofolate reductase1.5.1.30.476
2xf3J01Uncharacterized protein/0.476
1rvvINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.475
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.475
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.475
4bftZVTPantothenate kinase2.7.1.330.475
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.475
1cznFMNFlavodoxin/0.474
1dggNDPCatalase1.11.1.60.474
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.474
3c10TSNHistone deacetylase 73.5.1.980.474
3ce0P34Poly [ADP-ribose] polymerase 32.4.2.300.474
3nn6HNK6-hydroxy-L-nicotine oxidase/0.474
4b68NAPL-ornithine N(5)-monooxygenase/0.474
5a4wQCTGlutathione S-transferase F22.5.1.180.474
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.473
1w06W05Isopenicillin N synthase1.21.3.10.473
2jgbMGTEukaryotic translation initiation factor 4E type 2/0.473
3e4aQIXInsulin-degrading enzyme3.4.24.560.473
3q99H4BNitric oxide synthase, brain1.14.13.390.473
4pnmNU1Tankyrase-22.4.2.300.473
5cc9DDFDihydrofolate reductase1.5.1.30.473
1qiqACCIsopenicillin N synthase1.21.3.10.472
2qjpANJCytochrome b/0.472
2qt0NNRNicotinamide riboside kinase 1/0.472
3c6n2S8Protein TRANSPORT INHIBITOR RESPONSE 1/0.472
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.472
4dyp0MSNucleoprotein/0.472
1dpmEBPParathion hydrolase3.1.8.10.471
2vdyHCYCorticosteroid-binding globulin/0.471
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.471
5ilwURIRibosome inactivating protein/0.471
2y0468HBeta-1 adrenergic receptor/0.471
1xr2C2F5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase2.1.1.140.470
2qxxTTPdCTP deaminase3.5.4.130.470
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.470
4j3mAJ8Tankyrase-22.4.2.300.470
1dgbNDPCatalase1.11.1.60.469
1u0wSTLChalcone synthase 22.3.1.740.469
2c2bSAMThreonine synthase 1, chloroplastic4.2.3.10.469
2fzjDH3Dihydrofolate reductase1.5.1.30.469
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.469
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.469
4blcNDPCatalase1.11.1.60.469
4jt91NSNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.469
2iqdLPAAldose reductase1.1.1.210.468
2pdfZSTAldose reductase1.1.1.210.468
2xnmWGZSerine/threonine-protein kinase Nek22.7.11.10.468
3bt9DEQHTH-type transcriptional regulator QacR/0.468
3dlaNXXGlutamine-dependent NAD(+) synthetase6.3.5.10.468
4mx11MXRicin3.2.2.220.468
4r08URIToll-like receptor 8/0.468
4u140HKMuscarinic acetylcholine receptor M3/0.468
1uhjCZBAequorin-2/0.467
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.467
2vq3NAPMetalloreductase STEAP3/0.467
3gyf51PDihydrofolate reductase1.5.1.30.467
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.467
4cthRDFNeprilysin/0.467
4jpg1OXPyruvate kinase PKM2.7.1.400.467
1fmlRTLRetinol dehydratase/0.466
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.466
1t40ID5Aldose reductase1.1.1.210.466
2pucGUNHTH-type transcriptional repressor PurR/0.466
3b8hNADExotoxin A2.4.2.360.466
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.466
3k47D09Dihydrofolate reductase1.5.1.30.466
3nlqH4BNitric oxide synthase, brain1.14.13.390.466
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.466
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.466
4fam0SZAldo-keto reductase family 1 member C3/0.466
4i5xFLFAldo-keto reductase family 1 member B101.1.10.466
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.466
4jq1NPSAldo-keto reductase family 1 member C2/0.466
4jtrIZPAldo-keto reductase family 1 member C2/0.466
4nt3ZAWLactoperoxidase1.11.1.70.466
1b2rFADFerredoxin--NADP reductase1.18.1.20.465
1dhfFOLDihydrofolate reductase1.5.1.30.465
1g3mPCQEstrogen sulfotransferase2.8.2.40.465
1ihiIU5Aldo-keto reductase family 1 member C2/0.465
1n5vNOMActVA 6 protein/0.465
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.465
1pwyAC2Purine nucleoside phosphorylase2.4.2.10.465
2d06ESTSulfotransferase 1A12.8.2.10.465
2vcmM11Isopenicillin N synthase1.21.3.10.465
4bfq083Soluble acetylcholine receptor/0.465
4cx4H4BNitric oxide synthase, brain1.14.13.390.465
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.465
4r07URIToll-like receptor 8/0.465
4tjy3GNTankyrase-22.4.2.300.465
5arkUMPRibonuclease 43.1.270.465
1dghNDPCatalase1.11.1.60.464
1rkpIBMcGMP-specific 3',5'-cyclic phosphodiesterase/0.464
1s3uTQDDihydrofolate reductase1.5.1.30.464
1sm4FADFerredoxin--NADP reductase/0.464
2p1v5TNRetinoic acid receptor RXR-alpha/0.464
2wo7ASVIsopenicillin N synthase1.21.3.10.464
4bb3KKAIsopenicillin N synthase1.21.3.10.464
5a4vQUEGlutathione S-transferase F22.5.1.180.464
1pkfEPDEpothilone C/D epoxidase1.140.463
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.463
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.463
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.463
2vbpVB1Isopenicillin N synthase1.21.3.10.463
3dz6M8ES-adenosylmethionine decarboxylase proenzyme4.1.1.500.463
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.463
3ptzUDXUDP-glucose 6-dehydrogenase1.1.1.220.463
3zhvTDWMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.463
1s1rNAPAldo-keto reductase family 1 member C3/0.462
1xf0ASDAldo-keto reductase family 1 member C3/0.462
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.462
3d80Q22Dihydrofolate reductase1.5.1.30.462
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.462
4y9xUPGGlucosyl-3-phosphoglycerate synthase2.4.1.2660.462
7catNDPCatalase1.11.1.60.462
1dr4HBIDihydrofolate reductase1.5.1.30.461
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.461
1pd9CO4Dihydrofolate reductase1.5.1.30.461
1queFADFerredoxin--NADP reductase1.18.1.20.461
1r5hAO2Methionine aminopeptidase 2/0.461
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.461
2zozETTranscriptional regulator/0.461
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.461
3p9tTCLRepressor/0.461
3pahXDEPhenylalanine-4-hydroxylase1.14.16.10.461
3qiyQI1Botulinum neurotoxin type A3.4.24.690.461
4jvnYUGEstrogen sulfotransferase2.8.2.40.461
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.461
4qtnNNRNicotinamide riboside transporter PnuC/0.461
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
2aot2PMHistamine N-methyltransferase2.1.1.80.460
2rqfJH3Hemolymph juvenile hormone binding protein/0.460
3k4551PDihydrofolate reductase1.5.1.30.460
3w3lRX8Toll-like receptor 8/0.460
4dbs0HVAldo-keto reductase family 1 member C3/0.460
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.460
8catNDPCatalase1.11.1.60.460
1exa394Retinoic acid receptor gamma/0.459
1kf6HQOFumarate reductase iron-sulfur subunit1.3.5.10.459
1kf6HQOFumarate reductase subunit C/0.459
1kf6HQOFumarate reductase subunit D/0.459
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.459
2mm3CHOGastrotropin/0.459
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.459
3eszFMNFlavodoxin/0.459
3uftH4BNitric oxide synthase, brain1.14.13.390.459
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.459
4jtqFLPAldo-keto reductase family 1 member C2/0.459
4kbyC2EStimulator of interferon genes protein/0.459
4msg2C6Tankyrase-12.4.2.300.459
1isjNMNADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.60.458
1lgtBP3Biphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.458
1oc1ASVIsopenicillin N synthase1.21.3.10.458
1qtiGNTAcetylcholinesterase3.1.1.70.458
1s36CEIObelin/0.458
2ckmAA7Acetylcholinesterase3.1.1.70.458
2geuCOKPantothenate kinase2.7.1.330.458
2iviACWIsopenicillin N synthase1.21.3.10.458
2r6jNDPEugenol synthase 11.1.1.3180.458
2xi4AFTAcetylcholinesterase3.1.1.70.458
2yp0OVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.458
3d5wADPSerine/threonine-protein kinase PLK/0.458
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.458
3iu9T07Methionine aminopeptidase 2/0.458
3nljH4BNitric oxide synthase, brain1.14.13.390.458
3p0fBAUUridine phosphorylase 22.4.2.30.458
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.458
4dbuBT9Aldo-keto reductase family 1 member C3/0.458
4g1nNZTPyruvate kinase PKM2.7.1.400.458
4imtH4BNitric oxide synthase, brain1.14.13.390.458
4m6l21VDihydrofolate reductase1.5.1.30.458
1ah3TOLAldose reductase1.1.1.210.457
1w1wAGSStructural maintenance of chromosomes protein 1/0.457
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
1z4iUMP5'(3')-deoxyribonucleotidase, mitochondrial3.1.30.457
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.457
2p1u4TNRetinoic acid receptor RXR-alpha/0.457
3p0eBAUUridine phosphorylase 22.4.2.30.457
3qwc98PProthrombin3.4.21.50.457
3seqNXXGlutamine-dependent NAD(+) synthetase6.3.5.10.457
3ugrIMNAldo-keto reductase family 1 member C3/0.457
3v3nMIYTetX family tetracycline inactivation enzyme/0.457
3vo2FADFerredoxin--NADP reductase/0.457
4r5wXAVPoly [ADP-ribose] polymerase 12.4.2.300.457
4tnzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.457
5e9eANPMyosin heavy chain kinase A2.7.11.70.457
1dp2LPBThiosulfate sulfurtransferase/0.456
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.456
1ot3THMDeoxynucleoside kinase/0.456
1w6jR71Lanosterol synthase5.4.99.70.456
2jj8AZZDeoxynucleoside kinase/0.456
2pb1NFGGlucan 1,3-beta-glucosidase/0.456
2r6kGTXGlutathione S-transferase A12.5.1.180.456
2yatEEUEstrogen receptor/0.456
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.456
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.456
3gg2UGASugar dehydrogenase, UDP-glucose/GDP-mannose dehydrogenase family/0.456
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.456
3nloH4BNitric oxide synthase, brain1.14.13.390.456
3ufqH4BNitric oxide synthase, brain1.14.13.390.456
3ug8IMNAldo-keto reductase family 1 member C3/0.456
3zoiM2WIsopenicillin N synthase1.21.3.10.456
4ba5PXGProbable aminotransferase/0.456
4jhiEMUNodulin-13/0.456
4mt92D6Tankyrase-12.4.2.300.456
5d6lCAUBeta-2 adrenergic receptor/0.456
1blzACVIsopenicillin N synthase1.21.3.10.455
1kmvLIIDihydrofolate reductase1.5.1.30.455
1px0RPNHalohydrin dehalogenase/0.455
2v57PRLTetR family transcriptional regulator/0.455
2zevIPEGeranylgeranyl pyrophosphate synthase/0.455
3b82NADExotoxin A2.4.2.360.455
3h0vM2TS-adenosylmethionine decarboxylase proenzyme4.1.1.500.455
3jq7DX2Pteridine reductase, putative/0.455
3jwtH4BNitric oxide synthase, brain1.14.13.390.455
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.455
4cbyKEEHistone deacetylase 43.5.1.980.455
4flkY10Methionine aminopeptidase 1/0.455
5aglH4BNitric oxide synthase, brain1.14.13.390.455
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.454
1go2FADFerredoxin--NADP reductase1.18.1.20.454
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.454
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
1yciNDFHypoxia-inducible factor 1-alpha inhibitor1.14.11.300.454
1yw9A84Methionine aminopeptidase 2/0.454
2e93B29Geranylgeranyl pyrophosphate synthase/0.454
2fzdTOLAldose reductase1.1.1.210.454
2pdaTPPPyruvate synthase/0.454
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.454
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.454
3d4bDZDNAD-dependent protein deacetylase/0.454
3t0kDCQSulfide-quinone reductase/0.454
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.454
4bfyZVYPantothenate kinase2.7.1.330.454
4bvhOCZNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.454
4f0e0RUPoly [ADP-ribose] polymerase 152.4.2.300.454
4j7gTRHPCZA361.3/0.454
4jqaID8Aldo-keto reductase family 1 member C2/0.454
4jvlESTEstrogen sulfotransferase2.8.2.40.454
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
4xo7ASDAldo-keto reductase family 1 member C2/0.454
5c1gGDUHisto-blood group ABO system transferase/0.454
1gm8SOXPenicillin G acylase3.5.1.110.453
1n0sFLUBilin-binding protein/0.453
1xm1GAHProthrombin3.4.21.50.453
1yc2APRNAD-dependent protein deacylase 2/0.453
1zuaTOLAldo-keto reductase family 1 member B101.1.10.453
2b04CHOPhospholipase A2, major isoenzyme3.1.1.40.453
2f2sCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.453
2ipjFFAAldo-keto reductase family 1 member C2/0.453
2w6cBM4Acetylcholinesterase3.1.1.70.453
2z2w770Wee1-like protein kinase2.7.10.20.453
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
3kroIPEGeranyl diphosphate synthase large subunit/0.453
3q0uLL3HTH-type transcriptional regulator EthR/0.453
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.453
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.453
4aoaIK2Beta-phenylalanine transaminase2.6.10.453
4bj9UHBTankyrase-22.4.2.300.453
4ey20RMMetallo-beta-lactamase type 2/0.453
4g2wNI0cGMP-specific 3',5'-cyclic phosphodiesterase/0.453
4lsjLSJGlucocorticoid receptor/0.453
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.452
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.452
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.452
2imkGTXAGAP009194-PA/0.452
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.452
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.452
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
3jx4H4BNitric oxide synthase, brain1.14.13.390.452
3lqlLDTAldose reductase1.1.1.210.452
3nxyD2HDihydrofolate reductase1.5.1.30.452
3pneH4BNitric oxide synthase, brain1.14.13.390.452
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.452
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.452
4bfsZVSPantothenate kinase2.7.1.330.452
4fllYZ6Methionine aminopeptidase 1/0.452
4g090VDHistidinol dehydrogenase/0.452
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.452
4wevSUZAldo-keto reductase family 1 member B101.1.10.452
4xt8TMQPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc/0.452
5agkH4BNitric oxide synthase, brain1.14.13.390.452
1gaqFADFerredoxin/0.451
1u1d181Uridine phosphorylase2.4.2.30.451
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.451
2fjm073Tyrosine-protein phosphatase non-receptor type 13.1.3.480.451
3b78NADExotoxin A2.4.2.360.451
3g72A6TRenin3.4.23.150.451
3mb9ZSTAldose reductase1.1.1.210.451
3nu03TUDihydrofolate reductase1.5.1.30.451
3nxrD2DDihydrofolate reductase1.5.1.30.451
3r7nASP_VAL_ALA_ACE_ASACaspase-23.4.22.550.451
4k4eK4ETankyrase-12.4.2.300.451
4p9cDCMDeoxycytidylate deaminase/0.451
4to2DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.451
5brpPNGGlycoside Hydrolase Family 13/0.451
1fvpFMANon-fluorescent flavoprotein/0.450
1hfqMOTDihydrofolate reductase1.5.1.30.450
1hfrMOTDihydrofolate reductase1.5.1.30.450
1i7cMGBS-adenosylmethionine decarboxylase proenzyme4.1.1.500.450
1pqc444Oxysterols receptor LXR-beta/0.450
1vi0DCCFatty acid metabolism regulator protein/0.450
1w87FADFerredoxin--NADP reductase1.18.1.20.450
1x8lOXRRetinol dehydratase/0.450
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
2g1n1IGRenin3.4.23.150.450
2j3qTFLAcetylcholinesterase3.1.1.70.450
2nnqT4BFatty acid-binding protein, adipocyte/0.450
2ql6TIZNicotinamide riboside kinase 1/0.450
2uxhQUEHTH-type transcriptional regulator TtgR/0.450
2w03ADNAcsD/0.450
3djlFADPutative acyl-CoA dehydrogenase AidB1.3.990.450
3iej599Cathepsin S3.4.22.270.450
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.450
4rxqDUTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.450
4xp4COCSodium-dependent dopamine transporter/0.450
5fuwTHMThymidine kinase, putative/0.450
1hb3SCVIsopenicillin N synthase1.21.3.10.449
1ja1FMNNADPH--cytochrome P450 reductase/0.449
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
1zhyCLROxysterol-binding protein homolog 4/0.449
2aj4ANPGalactokinase2.7.1.60.449
2ohiFMNType A flavoprotein FprA10.449
2pdq47DAldose reductase1.1.1.210.449
2wd8VGFPteridine reductase/0.449
3exnACOProbable acetyltransferase/0.449
4boeCLRJapanin/0.449
4mm729JNa(+):neurotransmitter symporter (Snf family)/0.449
4p9dTMPDeoxycytidylate deaminase/0.449
5dsyUHBPoly [ADP-ribose] polymerase 22.4.2.300.449
1d7oTCLEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.448
1fkgSB3Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.448
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.448
1kyyINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
1pq944BOxysterols receptor LXR-beta/0.448
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.448
1re0AFBADP-ribosylation factor 1/0.448
1re0AFBARF guanine-nucleotide exchange factor 1/0.448
1uhlMEIRetinoic acid receptor RXR-beta/0.448
2b96ANNPhospholipase A23.1.1.40.448
2g7yMO9Cathepsin S3.4.22.270.448
3cv6HXSAldo-keto reductase family 1 member C21/0.448
3f8sPF2Dipeptidyl peptidase 4/0.448
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.448
4i421HA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.448
4rn615UProthrombin3.4.21.50.448
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.448
4ug5XFKNitric oxide synthase oxygenase1.14.13.1650.448
5liu388Aldo-keto reductase family 1 member B101.1.10.448
1b9iPXG3-amino-5-hydroxybenzoate synthase4.2.1.1440.447
1cq6PY4Aspartate aminotransferase2.6.1.10.447
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.447
1thnADPAnti-sigma F factor/0.447
1u1gBBBUridine phosphorylase2.4.2.30.447
1u65CP0Acetylcholinesterase3.1.1.70.447
2vt4P32Beta-1 adrenergic receptor/0.447
2xnoED8Serine/threonine-protein kinase Nek22.7.11.10.447
2xveFADPutative flavin-containing monooxygenase/0.447
3cqeP91Wee1-like protein kinase2.7.10.20.447
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3jwuH4BNitric oxide synthase, brain1.14.13.390.447
3l7gM44Xaa-Pro dipeptidase3.4.13.90.447
3o9lLPNRenin3.4.23.150.447
4dyn0MRNucleoprotein/0.447
4fw0H4BNitric oxide synthase, brain1.14.13.390.447
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.447
4usuAPCAdenylate cyclase type 10/0.447
1by5GLY_GLY_GLY_AHO_AHO_AHO_FEFerrichrome-iron receptor/0.446
1dd6MCIMetallo-beta-lactamase type 2/0.446
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.446
1r5gAO1Methionine aminopeptidase 2/0.446
1rx3MTXDihydrofolate reductase1.5.1.30.446
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.446
1w35FADFerredoxin--NADP reductase1.18.1.20.446
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.446
2b8jADNClass B acid phosphatase3.1.3.20.446
2bf7HBIPteridine reductase 11.5.1.330.446
2io6330Wee1-like protein kinase2.7.10.20.446
2qdsMCOMetallo-beta-lactamase type 2/0.446
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.446
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.446
2x9gLYAPteridine reductase/0.446
2ycwCAUBeta-1 adrenergic receptor/0.446
3cvkN34Genome polyprotein2.7.7.480.446
3ebiBEYM1 family aminopeptidase3.4.110.446
3hiiPNTAmiloride-sensitive amine oxidase [copper-containing]/0.446
3n61H4BNitric oxide synthase, brain1.14.13.390.446
3nlzH4BNitric oxide synthase, brain1.14.13.390.446
3oagLPQRenin3.4.23.150.446
3owuEQUSteroid Delta-isomerase5.3.3.10.446
3r8hZOMAldo-keto reductase family 1 member C3/0.446
3znqSS8D-amino-acid oxidase1.4.3.30.446
4fj0HHF17beta-hydroxysteroid dehydrogenase/0.446
4jseH4BNitric oxide synthase, brain1.14.13.390.446
4kn104JFolate receptor beta/0.446
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.446
1h66RH1NAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1klkPMDDihydrofolate reductase1.5.1.30.445
1p72THMThymidine kinase/0.445
1pj6FOLDimethylglycine oxidase1.5.3.100.445
1q63AIQQueuine tRNA-ribosyltransferase2.4.2.290.445
1s9dAFBCytohesin-2/0.445
1s9dAFBADP-ribosylation factor 1/0.445
1typNAPTrypanothione reductase1.8.1.120.445
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.445
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
2fzbTOLAldose reductase1.1.1.210.445
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.445
2rds1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.445
2w3aTOPDihydrofolate reductase1.5.1.30.445
3c0zSHHHistone deacetylase 73.5.1.980.445
3d74NBBPheromone-binding protein ASP1/0.445
3d77NBBPheromone-binding protein ASP1/0.445
3dhk23UProthrombin3.4.21.50.445
3gncQQQGlutaryl-CoA dehydrogenase/0.445
3jq8DX3Pteridine reductase, putative/0.445
3l3rOAGDihydrofolate reductase1.5.1.30.445
3m34TPPTransketolase/0.445
3n3aFMNProtein NrdI/0.445
3n5xXFKNitric oxide synthase, brain1.14.13.390.445
3tg4SAMN-lysine methyltransferase SMYD2/0.445
4bz8J38Histone deacetylase/0.445
4jsiH4BNitric oxide synthase, brain1.14.13.390.445
4kn0MTXFolate receptor beta/0.445
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.444
1dmwHBIPhenylalanine-4-hydroxylase1.14.16.10.444
1ej3CZHAequorin-2/0.444
1g63FMNEpidermin decarboxylase4.1.10.444
1h42FADFerredoxin--NADP reductase1.18.1.20.444
1odnAPVIsopenicillin N synthase1.21.3.10.444
1q13TESProstaglandin-E(2) 9-reductase1.1.1.1890.444
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
1y6rMTM5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase3.2.2.90.444
1ypjUIBProthrombin3.4.21.50.444
1yryMSGPurine nucleoside phosphorylase2.4.2.10.444
1zgcA2EAcetylcholinesterase3.1.1.70.444
2ixkTDOdTDP-4-dehydrorhamnose 3,5-epimerase5.1.3.130.444
2p1t3TNRetinoic acid receptor RXR-alpha/0.444
2pdlTOLAldose reductase1.1.1.210.444
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.444
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.444
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.444
3fznD7KBenzoylformate decarboxylase4.1.1.70.444
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.444
3uyk0CXProbable NDP-rhamnosyltransferase/0.444
4b67NAPL-ornithine N(5)-monooxygenase/0.444
4bjcRPBTankyrase-22.4.2.300.444
4cb4MGTPolymerase basic protein 2/0.444
4fvyH4BNitric oxide synthase, brain1.14.13.390.444
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.444
4iilRBFMembrane lipoprotein TpN38(b)/0.444
4jsgH4BNitric oxide synthase, brain1.14.13.390.444
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.444
4mvcCDCCholine-phosphate cytidylyltransferase A/0.444
4n1fCZHObelin/0.444
4nbn2J7Caspase-63.4.22.590.444
4paaTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.444
4pahLNRPhenylalanine-4-hydroxylase1.14.16.10.444
1jf2CZHObelin/0.443
1ux0THUCytidine deaminase3.5.4.50.443
1w29TS06,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
1xzqFONtRNA modification GTPase MnmE3.6.50.443
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.443
2wu4HBPAcetylcholinesterase3.1.1.70.443
2y01Y00Beta-1 adrenergic receptor/0.443
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3fr5I4AFatty acid-binding protein, adipocyte/0.443
3gluLYS_VAL_METNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.443
3h4vDVPPteridine reductase 11.5.1.330.443
3l3lL3LPoly [ADP-ribose] polymerase 12.4.2.300.443
3qbwADPAnhydro-N-acetylmuramic acid kinase/0.443
3qj0QI3Botulinum neurotoxin type A3.4.24.690.443
3rqkH4BNitric oxide synthase, brain1.14.13.390.443
3sfy3FYUncharacterized protein/0.443
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
4je5PLPAromatic/aminoadipate aminotransferase 12.6.1.390.443
4kl1PCGPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.443
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.443
4zmeADNMyosin heavy chain kinase A2.7.11.70.443
1drfFOLDihydrofolate reductase1.5.1.30.442
1fcy564Retinoic acid receptor gamma/0.442
1i59ANPChemotaxis protein CheA2.7.13.30.442
1isgAGSADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.60.442
1mrqSTRAldo-keto reductase family 1 member C1/0.442
1mvtDTMDihydrofolate reductase1.5.1.30.442
1om5H4BNitric oxide synthase, brain1.14.13.390.442
1qsnCOAHAT A1/0.442
1rs6H4BNitric oxide synthase, brain1.14.13.390.442
1touB1VFatty acid-binding protein, adipocyte/0.442
1z5uCMPClass B acid phosphatase/0.442
2c9bPUG6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
2cbqTH2Neocarzinostatin/0.442
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.442
2f59INI6,7-dimethyl-8-ribityllumazine synthase 1/0.442
2poqISDTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase1.3.1.200.442
2q3eUPGUDP-glucose 6-dehydrogenase1.1.1.220.442
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.442
2v7qADPATP synthase subunit beta, mitochondrial3.6.3.140.442
2w3mFOLDihydrofolate reductase1.5.1.30.442
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3zrbOR8Progesterone receptor/0.442
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.442
4ax8SAMO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.442
4gh10WXQueuine tRNA-ribosyltransferase2.4.2.290.442
4jq2SUZAldo-keto reductase family 1 member C2/0.442
4jsr1NQNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.442
4kfj1R0Dihydrofolate reductase1.5.1.30.442
4m6kFOLDihydrofolate reductase1.5.1.30.442
4o8jADNRNA 3'-terminal phosphate cyclase6.5.1.40.442
5c1mCLRMu-type opioid receptor/0.442
2yczI32Beta-1 adrenergic receptor/0.442
1dg7WRBDihydrofolate reductase1.5.1.30.441
1h22E10Acetylcholinesterase3.1.1.70.441
1m67BOAGlycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal1.1.1.80.441
1mmvH4BNitric oxide synthase, brain1.14.13.390.441
1og1TADT-cell ecto-ADP-ribosyltransferase 2/0.441
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.441
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.441
1ygkRRCPyridoxal kinase2.7.1.350.441
1yhjR6CPyridoxal kinase2.7.1.350.441
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.441
2d2gDZZPhosphotriesterase/0.441
2gv8NDPThiol-specific monooxygenase1.14.130.441
2opbF21Phenylethanolamine N-methyltransferase2.1.1.280.441
2x7tWZBCarbonic anhydrase 24.2.1.10.441
2zitNADExotoxin A2.4.2.360.441
3csoXNIGenome polyprotein2.7.7.480.441
3dzjNMNADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.441
3ghtLDTAldose reductase1.1.1.210.441
3hv3R49Mitogen-activated protein kinase 14/0.441
3jx2H4BNitric oxide synthase, brain1.14.13.390.441
3llaACPMyosin heavy chain kinase A2.7.11.70.441
3lutNAPVoltage-gated potassium channel subunit beta-2/0.441
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
4gaaBESLeukotriene A(4) hydrolase/0.441
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.441
4gqiM49Ribosyldihydronicotinamide dehydrogenase [quinone]/0.441
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.441
4pmjNAPPutative oxidoreductase/0.441
4rpgGDUUDP-galactopyranose mutase5.4.99.90.441
5pahLDPPhenylalanine-4-hydroxylase1.14.16.10.441
5f8uP32Beta-1 adrenergic receptor/0.441
1e63FADFerredoxin--NADP reductase1.18.1.20.440
1frbZSTAldose reductase-related protein 2/0.440
1gr1FADFerredoxin--NADP reductase1.18.1.20.440
1kwcBPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.440
1lrmHBIPhenylalanine-4-hydroxylase1.14.16.10.440
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
1y6oMJIPhospholipase A2, major isoenzyme3.1.1.40.440
1yw8A75Methionine aminopeptidase 2/0.440
1zgbA1EAcetylcholinesterase3.1.1.70.440
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.440
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.440
2j0sANPEukaryotic initiation factor 4A-III3.6.4.130.440
2o6hINI6,7-dimethyl-8-ribityllumazine synthase 12.5.1.780.440
2q0gUPUPoly(A) polymerase, putative/0.440
2vteIK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
3gn2AX8Pteridine reductase/0.440
3h3r14HCollagen type IV alpha-3-binding protein/0.440
3mzbBHRNickel-binding periplasmic protein/0.440
3nhpHGZRibosyldihydronicotinamide dehydrogenase [quinone]/0.440
3q7fED2Uncharacterized protein/0.440
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.440
4dz5NAPAldo-keto reductase family 1 member C3/0.440
4f1q0RZPoly [ADP-ribose] polymerase 142.4.2.300.440
4f1tH52Probable serine/threonine-protein kinase roco42.7.11.10.440
4g0k0VSGlutathionyl-hydroquinone reductase YqjG1.80.440
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.440
4m4821BSodium-dependent dopamine transporter/0.440
5kf2ACOPredicted acetyltransferase/0.440