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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ieiZESAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ieiZESAldose reductase1.1.1.211.000
3mb9ZSTAldose reductase1.1.1.210.623
2dv0ZSTAldose reductase1.1.1.210.595
2hv5ZSTAldose reductase1.1.1.210.589
2pdu393Aldose reductase1.1.1.210.589
2fz9ZSTAldose reductase1.1.1.210.588
2pdp393Aldose reductase1.1.1.210.573
2pdxZSTAldose reductase1.1.1.210.567
2i16LDTAldose reductase1.1.1.210.560
2fz8ZSTAldose reductase1.1.1.210.559
3ld5LDTAldose reductase1.1.1.210.559
3ghrLDTAldose reductase1.1.1.210.556
1z3n3NAAldose reductase1.1.1.210.554
3ghsLDTAldose reductase1.1.1.210.553
2iki388Aldose reductase1.1.1.210.549
2pdfZSTAldose reductase1.1.1.210.548
3m64393Aldose reductase1.1.1.210.548
2qxwLDTAldose reductase1.1.1.210.543
4gca2X9Aldose reductase1.1.1.210.543
2pdc393Aldose reductase1.1.1.210.540
1t40ID5Aldose reductase1.1.1.210.539
2pdj393Aldose reductase1.1.1.210.538
3lboLDTAldose reductase1.1.1.210.538
3lqlLDTAldose reductase1.1.1.210.536
1z8962PAldose reductase1.1.1.210.533
2pdmZSTAldose reductase1.1.1.210.533
3m0iZSTAldose reductase1.1.1.210.528
3ghtLDTAldose reductase1.1.1.210.526
1pwlBFIAldose reductase1.1.1.210.525
2ikj393Aldose reductase1.1.1.210.525
1t41ID5Aldose reductase1.1.1.210.524
3lz5LDTAldose reductase1.1.1.210.522
2pzn393Aldose reductase1.1.1.210.519
3lenZSTAldose reductase1.1.1.210.519
2hvoZSTAldose reductase1.1.1.210.517
3g5eQ74Aldose reductase1.1.1.210.517
3mc5393Aldose reductase1.1.1.210.517
3m4h388Aldose reductase1.1.1.210.516
2pdg47DAldose reductase1.1.1.210.512
2pdq47DAldose reductase1.1.1.210.511
2duzZSTAldose reductase1.1.1.210.510
3ghuLDTAldose reductase1.1.1.210.509
2duxZSTAldose reductase1.1.1.210.507
2pdlTOLAldose reductase1.1.1.210.506
1us0LDTAldose reductase1.1.1.210.505
2pdn47DAldose reductase1.1.1.210.505
1ry8RUTAldo-keto reductase family 1 member C3/0.503
2pdh47DAldose reductase1.1.1.210.500
2i17LDTAldose reductase1.1.1.210.499
2pdiZSTAldose reductase1.1.1.210.499
1pqc444Oxysterols receptor LXR-beta/0.497
1zuaTOLAldo-keto reductase family 1 member B101.1.10.496
2hvnZSTAldose reductase1.1.1.210.493
2fzdTOLAldose reductase1.1.1.210.491
1frbZSTAldose reductase-related protein 2/0.490
2pdyFIDAldose reductase1.1.1.210.487
3t423T4Aldose reductase1.1.1.210.487
2f2kTGGAldose reductase1.1.1.210.480
2ikhLITAldose reductase1.1.1.210.478
5liu388Aldo-keto reductase family 1 member B101.1.10.478
4ga8SBIAldo-keto reductase family 1 member B101.1.10.477
4yu153NAldose reductase1.1.1.210.476
4phlPILPhosphodiesterase/0.475
1ah3TOLAldose reductase1.1.1.210.474
2pd5ZSTAldose reductase1.1.1.210.472
1q84TZ4Acetylcholinesterase3.1.1.70.471
2aot2PMHistamine N-methyltransferase2.1.1.80.471
2inzOHPAldose reductase1.1.1.210.470
2nvcITAAldose reductase1.1.1.210.470
4kfjFOLDihydrofolate reductase1.5.1.30.470
2iqdLPAAldose reductase1.1.1.210.469
2bjsACVIsopenicillin N synthase1.21.3.10.467
4yfy0FXVioF/0.467
3u2cSUZAldose reductase1.1.1.210.466
2pdbZSTAldose reductase1.1.1.210.465
3zkyWT4Isopenicillin N synthase1.21.3.10.462
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.461
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
3hiiPNTAmiloride-sensitive amine oxidase [copper-containing]/0.459
4epq0RRPoly(ADP-ribose) glycohydrolase/0.459
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.458
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.458
2agtFIDAldose reductase1.1.1.210.457
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
2y6fM9FIsopenicillin N synthase1.21.3.10.455
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.455
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.453
4dbs0HVAldo-keto reductase family 1 member C3/0.453
2aouCQAHistamine N-methyltransferase2.1.1.80.452
2vbpVB1Isopenicillin N synthase1.21.3.10.452
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.452
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.451
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.451
3f3y4OABile salt sulfotransferase2.8.2.140.451
3r8hZOMAldo-keto reductase family 1 member C3/0.451
1ry0PG2Aldo-keto reductase family 1 member C3/0.448
1w06W05Isopenicillin N synthase1.21.3.10.448
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.448
1bk0ACVIsopenicillin N synthase1.21.3.10.447
1blzACVIsopenicillin N synthase1.21.3.10.447
1ekoI84Aldose reductase1.1.1.210.447
1hb1OCVIsopenicillin N synthase1.21.3.10.447
1u65CP0Acetylcholinesterase3.1.1.70.447
3s3gTLTAldose reductase1.1.1.210.447
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.446
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.446
1q23FUAChloramphenicol acetyltransferase2.3.1.280.446
1eveE20Acetylcholinesterase3.1.1.70.445
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.445
1qtiGNTAcetylcholinesterase3.1.1.70.444
2y60M8FIsopenicillin N synthase1.21.3.10.444
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.444
1gj5130Prothrombin3.4.21.50.443
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.443
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.443
1zgcA2EAcetylcholinesterase3.1.1.70.442
2vcmM11Isopenicillin N synthase1.21.3.10.442
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.442
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
1odcA8BAcetylcholinesterase3.1.1.70.441
2xujTZ5Acetylcholinesterase3.1.1.70.441
3n0hTOPDihydrofolate reductase1.5.1.30.441
3v94WYQPhosphodiesterase/0.441
5stdUNNScytalone dehydratase4.2.1.940.441
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1o6qR17Squalene--hopene cyclase4.2.1.1290.440
2bu9HFVIsopenicillin N synthase1.21.3.10.440
2xlpNAPPutative flavin-containing monooxygenase/0.440
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.440
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.440
5ctoNTD4-hydroxyphenylpyruvate dioxygenase1.13.11.270.440