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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ie4T44Transthyretin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ie4T44Transthyretin/1.000
1sn5T3Transthyretin/0.593
1sn0T44Transthyretin/0.519
1tz8DESTransthyretin/0.514
1kgjFL8Transthyretin/0.504
1ictT44Transthyretin/0.481
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.475
2hcdBIVVitamin D3 receptor A/0.472
4ia2BIVVitamin D3 receptor A/0.470
4ia3BIVVitamin D3 receptor A/0.468
4e37NDPCatalase1.11.1.60.466
4ia7BIVVitamin D3 receptor A/0.465
3gubGUBDeath-associated protein kinase 12.7.11.10.453
3wdlATP4-phosphopantoate--beta-alanine ligase6.3.2.360.453
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.451
3vt8YI3Vitamin D3 receptor/0.450
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.449
2nnhREACytochrome P450 2C8/0.448
4rupH97Vitamin D3 receptor A/0.447
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.446
4ia1BIVVitamin D3 receptor A/0.445
4ruoBIVVitamin D3 receptor A/0.445
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.444
1jioDEB6-deoxyerythronolide B hydroxylase/0.443
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.443
3vt9YI4Vitamin D3 receptor/0.443
2q59240Peroxisome proliferator-activated receptor gamma/0.442
1bygSTUTyrosine-protein kinase CSK/0.441
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.441
3vthAPCCarbamoyltransferase/0.441
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.441
4ubsDIFPentalenic acid synthase1.14.15.110.441
3lu7IPXSerum albumin/0.440
3vt7VDXVitamin D3 receptor/0.440
4l9kEHFSerum albumin/0.440
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.440